Zobrazeno 1 - 10
of 57
pro vyhledávání: '"D M, Neville"'
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 2(9)
Most cancer patients receive chemotherapy drugs that target DNA or the cell division apparatus. Many of these patients develop multidrug-resistant tumor cells, thus, novel methods to overcome drug resistance are needed. One approach is to target tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04d09c303e950f5decf77868800b13fc
https://pubmed.ncbi.nlm.nih.gov/11717818
https://pubmed.ncbi.nlm.nih.gov/11717818
Autor:
J L, Contreras, D E, Eckhoff, S, Cartner, G, Bilbao, C, Ricordi, D M, Neville, F T, Thomas, J M, Thomas
Publikováno v:
Transplantation. 69(2)
Pancreatic islet transplantation (PIT) is an attractive alternative for patients with type I diabetes mellitus. PIT is not yet an effective clinical reality due in part to the high incidence of rejection and early loss of functional islet mass. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf1397526b97101241a0489bdbd5c2f1
https://pubmed.ncbi.nlm.nih.gov/10670626
https://pubmed.ncbi.nlm.nih.gov/10670626
Publikováno v:
Transplantation. 68(6)
Partially inbred miniature swine developed in this laboratory provide a unique preclinical large animal model for studying transplant tolerance. The importance of in vivo T cell depletion for establishing stable mixed hematopoietic cell chimerism usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68704bafbfdb9c9aed2772578fa6597f
https://pubmed.ncbi.nlm.nih.gov/10515387
https://pubmed.ncbi.nlm.nih.gov/10515387
Autor:
F T, Thomas, C, Ricordi, J L, Contreras, W J, Hubbard, X L, Jiang, D E, Eckhoff, S, Cartner, G, Bilbao, D M, Neville, J M, Thomas
Publikováno v:
Transplantation. 67(6)
Isolated pancreatic islet transplantation (IPITx) is an attractive alternative for treatment of insulin-dependent diabetes mellitus (IDDM). However, IPITx has been difficult to implement clinically because islets frequently fail to function, have a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e408359189bccaf5a27889b3af479d1d
https://pubmed.ncbi.nlm.nih.gov/10199733
https://pubmed.ncbi.nlm.nih.gov/10199733
Autor:
S J, Knechtle, J H, Fechner, Y, Dong, S, Stavrou, D M, Neville, T, Oberley, P, Buckley, N, Armstrong, K, Rusterholz, X, Hong, M, Tsuchida, M M, Hamawy
Publikováno v:
Surgery. 124(2)
T-lymphocyte depletion 7 days before transplantation with immunotoxin FN 18-CRM9 has resulted in tolerance to subsequent renal allografts. We tested the effect of giving immunotoxin on the day of the transplantation and evaluated its effect on rhesus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10830ba8d68d40006800d221b5d9e29c
https://pubmed.ncbi.nlm.nih.gov/9706169
https://pubmed.ncbi.nlm.nih.gov/9706169
Autor:
J M, Thomas, D M, Neville, J L, Contreras, D E, Eckhoff, G, Meng, A L, Lobashevsky, P X, Wang, Z Q, Huang, K M, Verbanac, C E, Haisch, F T, Thomas
Publikováno v:
Transplantation. 64(1)
A major challenge in clinical transplantation today is to design a practical and effective protocol for tolerance induction compatible with cadaver organ transplantation. A preclinical rhesus monkey kidney allograft model using immediate peritranspla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aaeec72a63fbed843530558b0eea2194
https://pubmed.ncbi.nlm.nih.gov/9233712
https://pubmed.ncbi.nlm.nih.gov/9233712
Autor:
J H, Fechner, D J, Vargo, E K, Geissler, C, Graeb, J, Wang, M J, Hanaway, D I, Watkins, M, Piekarczyk, D M, Neville, S J, Knechtle
Publikováno v:
Transplantation. 63(9)
Renal allografts were performed in rhesus monkeys using FN18-CRM9, a potent immunotoxin capable of depleting T cells to less than 1% of baseline levels in blood and lymph nodes, as a preparative agent. We have recently reported that animals pretreate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6647a86143a97e433cd4a17940fd7648
https://pubmed.ncbi.nlm.nih.gov/9158030
https://pubmed.ncbi.nlm.nih.gov/9158030
Autor:
S J, Knechtle, D, Vargo, J, Fechner, Y, Zhai, J, Wang, M J, Hanaway, J, Scharff, H, Hu, L, Knapp, D, Watkins, D M, Neville
Publikováno v:
Transplantation. 63(1)
Transplant tolerance, rather than immunity, may be favored in the setting of a lower mature lymphoid mass in the recipient induced by anti-T cell agents. A novel immunosuppressive agent, FN18-CRM9, known to specifically kill T cells with great potenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29e711ed3ec059deed96d5dc41849d27
https://pubmed.ncbi.nlm.nih.gov/9000652
https://pubmed.ncbi.nlm.nih.gov/9000652
Publikováno v:
The Journal of biological chemistry. 266(7)
The transferrin cycle was used to attempt the import of bioactive macromolecules into cells with the aid of an acid-labile cross-linking agent. Anti-tetanus F(ab')2 fragments were iodinated and then conjugated to transferrin with a newly developed ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::933db22a9366a47b95a335f02ca79dac
https://pubmed.ncbi.nlm.nih.gov/1671860
https://pubmed.ncbi.nlm.nih.gov/1671860
Autor:
H H, Wellhöner, H, Bigalke, T, Borcholte, G, Erdmann, T, Eschenhagen, K H, Jung, P, Marxen, U, Peukert, D M, Neville, K, Srinivasachar
Publikováno v:
Journal de physiologie. 84(3)
1. In order to introduce antitetanus immunoglobulin fragments into eukaryotic cells, either antitetanus F(ab')2 or Fab' fragments have been linked to carrier molecules. Aciclovir, horseradish peroxidase, wheat germ agglutinin, and transferrin were tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e6802774f4cdac00cf7b60fd439d8a4
https://pubmed.ncbi.nlm.nih.gov/2074544
https://pubmed.ncbi.nlm.nih.gov/2074544