Zobrazeno 1 - 10
of 26
pro vyhledávání: '"D M, Moccio"'
Publikováno v:
Journal of Biological Chemistry. 259:13139-13144
We have isolated stable variants of the L1210 cell exhibiting increased transport inward of the folate analog, methotrexate. These variants show 3- to 14-fold increases in [3H]methotrexate influx compared to parental cells but are unaltered for [3H]m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9653a7345a3179a11c96137c78ddb2c
https://doi.org/10.1016/s0021-9258(18)90668-x
https://doi.org/10.1016/s0021-9258(18)90668-x
Autor:
Francis M. Sirotnak, James R. Piper, James C. Parham, D. M. Moccio, Paul L. Chello, John A. Montgomery
Publikováno v:
Biochemical Pharmacology. 29:3293-3298
During studies with L1210 cells and a variety of folate analogs, large discrepancies were revealed between data on membrane transport, on inhibition of dihydrofolate reductase in cell-free extracts, and on inhibition of growth in culture for 10-oxa-,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9f8e462a4049ea58ff027b50578447
https://doi.org/10.1016/0006-2952(80)90306-8
https://doi.org/10.1016/0006-2952(80)90306-8
Publikováno v:
Biochemical pharmacology. 33(17)
Methotrexate (MTX) polyglutamates were detected in osteogenic sarcoma tumor samples obtained from patients 24 or 48 h after receiving high-dose MTX/leucovorin rescue therapy. Tumor samples were assayed by high-performance liquid chromatography, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142499845fdccb60968228d648271fd7
https://pubmed.ncbi.nlm.nih.gov/6205660
https://pubmed.ncbi.nlm.nih.gov/6205660
Autor:
F M, Sirotnak, D M, Moccio
Publikováno v:
Cancer research. 40(4)
Following s.c. administration of varying doses of methotrexate (12 to 400 mg/kg) to mice, the drug accumulated more rapidly and to much higher levels in the small intestine in comparison to bone marrow. The persistence of exchangeable levels of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ae781fa81179b8f1e89c61f99e4e656
https://pubmed.ncbi.nlm.nih.gov/7357552
https://pubmed.ncbi.nlm.nih.gov/7357552
Publikováno v:
Cancer treatment reports. 60(5)
The 5-arylpyrimidine antifolate DDMP showed appreciable therapeutic activity against an ascitic form of Sarcoma 180 in BD2F1 mice. Antitumor effects were highly schedule and dose dependent at a limited number of doses within the range of 8--40 mg/kg.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad13d9e08e2b1e624960bd1a39da9f69
https://pubmed.ncbi.nlm.nih.gov/1086715
https://pubmed.ncbi.nlm.nih.gov/1086715
Publikováno v:
Cancer research. 38(2)
An analysis of dose and schedule dependence of calcium leucovorin rescue during high-dose methotrexate therapy of ascitic forms of l1210 leukemia and Sarcoma 180 is reported. Schedules with very delayed "low-dose" leucovorin rescue following lethal d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7af00628cdc7c98a7ece02d71bcb6a46
https://pubmed.ncbi.nlm.nih.gov/304375
https://pubmed.ncbi.nlm.nih.gov/304375
Publikováno v:
Cancer research. 41(3)
Carrier-mediated influx and efflux of [3H]methotrexate by L1210 leukemia cells was inhibited by probenecid. The concentration of probenecid required for inhibition of influx was markedly greater than that required to inhibit efflux. The concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ec86e5bcda2d3c92897299bb4a3bdab
https://pubmed.ncbi.nlm.nih.gov/7459883
https://pubmed.ncbi.nlm.nih.gov/7459883
Publikováno v:
Cancer research. 41(11 Pt 1)
Information was sought on the relative extent to which transport-defective, methotrexate-resistant phenotypes emerge among the total subpopulation of resistant phenotypes during therapeutic challenge of leukemic cells in vivo. A number of monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3718d4a453215e8b6da7d40a77e01c69
https://pubmed.ncbi.nlm.nih.gov/7306968
https://pubmed.ncbi.nlm.nih.gov/7306968
Publikováno v:
Cancer treatment reports. 66(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e3767ac97d9f9f992179c5b9fe0bb48
https://pubmed.ncbi.nlm.nih.gov/7055818
https://pubmed.ncbi.nlm.nih.gov/7055818
Publikováno v:
Cancer treatment reports. 61(7)
Multiple-dose toxicity of the 5-arylpyrimidine DDMP showed marked seasonal variation and sex dependence in BD2F1 mice. Considerable therapeutic activity against the ascitic, solid, and intracranial forms of Sarcoma 180 was demonstrated. Antitumor eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e02b01d86da1408cd1f5949c745aecf5
https://pubmed.ncbi.nlm.nih.gov/303937
https://pubmed.ncbi.nlm.nih.gov/303937