Zobrazeno 1 - 10
of 13
pro vyhledávání: '"D M, Lillington"'
Publikováno v:
Cancer genetics and cytogenetics. 124(2)
Recent studies have identified several chromosome regions that are altered in primary prostate cancer and prostatic carcinoma cell lines. These targeted regions may harbor genes involved in tumor suppression. We used multiplex fluorescence in situ hy
Publikováno v:
Genes, chromosomescancer. 30(2)
The interstitial insertion of genetic material from one chromosome into another can achieve the type of gene-gene fusions more usually associated with chromosome translocations. An example of such an interstitial insertion, which has created an MLL-A
Publikováno v:
British journal of haematology. 111(3)
The signal transduction pathway through which tumour necrosis factor (TNF) induces apoptosis in leukaemic cells may involve activation of cytosolic phospholipase A(2) (cPLA(2)). The steroids dexamethasone (Dex) and 1,25(OH)(2) D(3) both render U937 l
Publikováno v:
Leukemia. 12(5)
Thirty patients representing 5.5% of those collected by the 11q23 workshop had a t(6;11)(q27;q23). They included 27cases of acute myeloid leukemia (AML) (M1, three cases; M2, two cases; M4, nine cases; M4/M5, one case; M5, 12 cases) of age range 3-72
Publikováno v:
Leukemia. 12(5)
The clinical, haematological and cytogenetic data for 20 patients with an acquired abnormality of 11q23 and 10p have been reviewed at this workshop. Patients predominantly presented with de novo AML M5a and the most common cytogenetic finding was an
Publikováno v:
Cancer research. 58(4)
The mechanism by which tumor necrosis factor (TNF) induces death of cancer cells appears to involve the activation of cytosolic phospholipase A2 (cPLA2). U937 human leukemic cells treated with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; 10(-8) M] become r
Publikováno v:
Journal of biological regulators and homeostatic agents. 11(3)
The lack of distinguishing characteristics between lymphoid blastic crisis (BC) of Philadelphia (Ph)+ chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) remains an exciting dilemma. Indeed, the genetic defect of approximately h
Autor:
A, Gregorini, F I, Sahin, D M, Lillington, J, Meerabux, V, Saha, P, McCullagh, M, Bocci, S, Menevse, S, Papa, B D, Young
Publikováno v:
Genes, chromosomescancer. 17(4)
The genes AF10 and AF17 have been identified as the basis of the t(10;11) and t(11;17) translocations, events that result in their fusion to the MLL/HRX gene in acute myeloid leukaemias. AF10 and AF17 bear significant homology to each other within th
Publikováno v:
Cancer genetics and cytogenetics. 87(1)
A case of acute myelogenous leukemia (AML) French-American-British (FAB)-type M5b is described, secondary to myelodysplastic syndrome (MDS), in which a primary clone containing a dup(1)(p22p36) and a subclone containing dup(1)(p22p36), were identifie
Autor:
D M, Lillington, S, Monard, P W, Johnson, M L, Evans, L U, Kearney, T A, Lister, B D, Young, B, Gibbons
Publikováno v:
Leukemia. 8(4)
Cytogenetic analysis of a bone marrow aspirate from a patient with acute lymphoblastic leukemia (ALL) revealed the presence of a complex karyotype containing the translocation, t(14;18)(q32;q21). Further investigations using fluorescence in situ hybr