Zobrazeno 1 - 10
of 14
pro vyhledávání: '"D M, Kokkinakis"'
Publikováno v:
British Journal of Cancer
Methionine (MET)-dependent cell lines require MET to proliferate, and homocysteine (HCY) does not act as a substitute for this requirement. From six O6-methylguanine-DNA methyltransferase (MGMT)-efficient (mer+) cell lines tested, two medulloblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7eb496a425293df85b3abcf359e5c0
http://europepmc.org/articles/PMC2063394
http://europepmc.org/articles/PMC2063394
Publikováno v:
Cancer research. 61(10)
This study describes a novel approach to the treatment of brain tumors with the combination of recombinant L-methionine-alpha-deamino-gamma-lyase and chemotherapeutic regimens that are currently used against such tumors. The growth of Daoy, SWB77, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ead1fed16e58ebb1230a2f199abab5da
https://pubmed.ncbi.nlm.nih.gov/11358820
https://pubmed.ncbi.nlm.nih.gov/11358820
Publikováno v:
Neuro-oncology. 3(2)
Glial tumors may originate from the malignant transformation of multipotent glial progenitor cells, but tools to study malignant transformation leading to gliomas are limited by the lack of biological systems that represent early stages of this disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::572c45735f08d859690b19f0dcbae4f2
https://pubmed.ncbi.nlm.nih.gov/11296486
https://pubmed.ncbi.nlm.nih.gov/11296486
Publikováno v:
Cancer research. 57(23)
Pancreatic adenocarcinomas rarely respond to radiation or chemotherapy, indicating that a large percentage of these tumors possess complex mechanisms of resistance. The failure of alkylating agents, such as carmustine [1,3-bis(2-chloroethyl)-1-nitros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d07b16e80f286a2d0b5a27a5a0b20c11
https://pubmed.ncbi.nlm.nih.gov/9393761
https://pubmed.ncbi.nlm.nih.gov/9393761
Publikováno v:
In vivo (Athens, Greece). 10(3)
O6-Benzyl-2'-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29b3e8253ac386f0ab48af60386608fe
https://pubmed.ncbi.nlm.nih.gov/8797031
https://pubmed.ncbi.nlm.nih.gov/8797031
Publikováno v:
Cancer research. 56(9)
O6-Methylguanine-DNA methyltransferase (MGMT), a constitutively expressed DNA repair protein, removes alkyl groups from the O6-position of guanine in DNA. Tumor cells with high MGMT activity are resistant to nitrosoureas and other agents that form to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ea8349fbb1132cf68d9e5d7281db2f8
https://pubmed.ncbi.nlm.nih.gov/8616853
https://pubmed.ncbi.nlm.nih.gov/8616853
Autor:
D M, Kokkinakis, J, Albores-Saavedra
Publikováno v:
Cancer research. 54(20)
The effect of dietary orotic acid (OA) in liver-pancreas carcinogenesis induced in female Syrian hamsters by N-Nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP) was evaluated. All animals infused with the carcinogen received the same doses. Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4317bebcf7159a2819daf9cc04738d47
https://pubmed.ncbi.nlm.nih.gov/7923160
https://pubmed.ncbi.nlm.nih.gov/7923160
Autor:
D M, Kokkinakis, V, Subbarao
Publikováno v:
Cancer research. 53(12)
N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) is a complete pancreatic carcinogen in female hamsters at a dose of 210 mg/kg given via an Alzet 2001 pump implanted s.c. Ultimate carcinogenic metabolites of HPOP target DNA to yield 7-and O6-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43a2973277203bc8e1aa2f5c7bcd3a56
https://pubmed.ncbi.nlm.nih.gov/8504421
https://pubmed.ncbi.nlm.nih.gov/8504421
Autor:
D M, Kokkinakis, D G, Scarpelli
Publikováno v:
Carcinogenesis. 10(4)
The effect of continuous week-long administration of the three pancreatic carcinogens N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP), N-nitrosobis(2-hydroxypropyl)amine (BHP), and cis-N-nitroso-2,6-dimethylmorpholine (cis-NNDM), by a s.c. implan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff0d090a977cac71505b9ab966a67c23
https://pubmed.ncbi.nlm.nih.gov/2649266
https://pubmed.ncbi.nlm.nih.gov/2649266
Autor:
D M, Kokkinakis, D G, Scarpelli
Publikováno v:
Cancer research. 49(12)
N-Nitrosobis(2-oxopropyl)amine (BOP) and N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) alkylate DNA and other macromolecules in the liver, kidney, pancreas, and lungs when injected s.c. in the Syrian hamster. Two of the most abundant DNA adduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4357dd7d17c114b5fcae12e92a4fbfbf
https://pubmed.ncbi.nlm.nih.gov/2720674
https://pubmed.ncbi.nlm.nih.gov/2720674