Výsledky vyhledávání - "D M, Holtzman"

Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system

Autor: D M, Holtzman, A M, Fagan

Publikováno v: Trends in cardiovascular medicine. 8(6)

Apolipoprotein E (apoE) is a well characterized 299 amino acid protein that participates in the regulation of plasma cholesterol and lipid metabolism. In humans, apoE has three major protein isoforms: E2 (cys(112), cys(158)); E3 (cys(112), arg(158));

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2fad078f1ac3be0f842201e5aba438b0
https://pubmed.ncbi.nlm.nih.gov/14987560

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Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

Autor: X, Han, D M, Holtzman, D W, McKeel

Publikováno v: Journal of neurochemistry. 77(4)

To explore the hypothesis that alterations in ethanolamine plasmalogen may be directly related to the severity of dementia in Alzheimer's disease (AD), we performed a systematic examination of plasmalogen content in cellular membranes of gray and whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc90b199523d5d05df48062d8296f75d
https://pubmed.ncbi.nlm.nih.gov/11359882

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Role of nerve growth factor in experimental autoimmune encephalomyelitis

Autor: L R, Arredondo, C, Deng, R B, Ratts, A E, Lovett-Racke, D M, Holtzman, M K, Racke

Publikováno v: European journal of immunology. 31(2)

The expression of neural regulatory molecules by immune cells that infiltrate the nervous system upon injury may be a mechanism for cross-regulation between the nervous system and the immune system. Several lines of evidence implicate nerve growth fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06fc104a66a2d7ecfa5b690db8ceb2d9
https://pubmed.ncbi.nlm.nih.gov/11180128

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No effect of apolipoprotein E on neuronal cell death due to excitotoxic and apoptotic agents in vitro and neonatal hypoxic ischaemia in vivo

Autor: C L, Lendon, B H, Han, K, Salimi, A M, Fagan, M I, Behrens, M C, Muller, D M, Holtzman

Publikováno v: The European journal of neuroscience. 12(7)

The epsilon4 allele of apolipoprotein E (apoE) is a genetic risk factor for Alzheimer's disease. Studies also suggest that the epsilon4 allele may be a risk factor for poor outcome following head trauma, brain haemorrhage and ischaemia. The mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba19e535397988f9dd8aaabe6904a67e
https://pubmed.ncbi.nlm.nih.gov/10947802

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Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype

Autor: A M, Fagan, L H, Younkin, J C, Morris, J D, Fryer, T G, Cole, S G, Younkin, D M, Holtzman

Publikováno v: Annals of neurology. 48(2)

The epsilon4 allele of apolipoprotein E (ApoE) is a risk factor for Alzheimer's disease (AD). ApoE, which is important for lipid metabolism, is also a major constituent of cerebrospinal fluid (CSF) lipoproteins (LPs). Although ApoE in the CSF is deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c26eb68e20e4c63c5196b92fc1a31a70
https://pubmed.ncbi.nlm.nih.gov/10939571

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Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta deposition in vivo

Autor: A M, Fagan, D M, Holtzman

Publikováno v: Microscopy research and technique. 50(4)

The genetic association between the E4 isoform of apolipoprotein E (apoE) and increased risk for Alzheimer's disease (AD) has prompted interest in the neurobiology of apoE and the possible relationship between lipoprotein metabolism in the brain and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f0a16ad6edb421918cf9340434fa0e15
https://pubmed.ncbi.nlm.nih.gov/10936884

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Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model

Autor: D M, Holtzman, A M, Fagan, B, Mackey, T, Tenkova, L, Sartorius, S M, Paul, K, Bales, K H, Ashe, M C, Irizarry, B T, Hyman

Publikováno v: Annals of neurology. 47(6)

The epsilon4 allele of apolipoprotein E (ApoE) is an important genetic risk factor for Alzheimer's disease (AD). Increasing evidence suggests that this association may be linked to the ability of ApoE to interact with the amyloid-beta (Abeta) peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd0cc9cbed2214927d02893aded0a36e
https://pubmed.ncbi.nlm.nih.gov/10852539

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Differential effects of cAMP in neurons and astrocytes. Role of B-raf

Autor: L L, Dugan, J S, Kim, Y, Zhang, R D, Bart, Y, Sun, D M, Holtzman, D H, Gutmann

Publikováno v: The Journal of biological chemistry. 274(36)

Mitogen-activated protein kinase (MAPK) activation provides cell type-specific signals important for cellular differentiation, proliferation, and survival. Cyclic AMP (cAMP) has divergent effects on MAPK activity depending on whether signaling is thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ce7cf88824d01c9f3fa11ccd4c78351
https://pubmed.ncbi.nlm.nih.gov/10464325

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