Zobrazeno 1 - 10
of 25
pro vyhledávání: '"D M, Heuman"'
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 12, Pp 2483-2491 (1997)
In primary cultures of rat hepatocytes, transcription of the cholesterol 7alpha-hydroxylase gene is induced synergistically by glucocorticoid and thyroid hormones. The objective of the present study was to evaluate the role of endogenous glucocortico
Externí odkaz:
https://doaj.org/article/07fadeb554a8476c893d58444424d6b5
Autor:
D M Heuman
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 6, Pp 1217-1228 (1997)
Bile salts are surfactants that partition into phospholipid bilayers. When liposomes or membranes are exposed to mixed solutions of bile salts, the more hydrophobic bile salt species associate preferentially with the lipid bilayer. As a consequence,
Externí odkaz:
https://doaj.org/article/1db14ac62d674aab94f41fc795822f10
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 3, Pp 562-573 (1996)
Tauroursodeoxycholate (TUDC), a relatively hydrophilic bile salt, reduces disruption of cholesterol-rich membranes by more hydrophobic bile salts such as taurocholate (TC), taurochenodeoxycholate (TCDC), or taurodeoxycholate (TDC). We examined the in
Externí odkaz:
https://doaj.org/article/3c77b09352ba4c5fac1511a4d8aa5296
Publikováno v:
Journal of Lipid Research, Vol 30, Iss 8, Pp 1161-1171 (1989)
Hepatic bile acid synthesis is thought to be under negative feedback control by bile salts in the enterohepatic circulation, acting at the level of cholesterol 7 alpha-hydroxylase (C7 alpha H), the initial and rate-limiting step in the bile acid bios
Externí odkaz:
https://doaj.org/article/ed78dba2e3764054b84e8709e238cb41
Autor:
D M Heuman
Publikováno v:
Journal of Lipid Research, Vol 30, Iss 5, Pp 719-730 (1989)
This paper describes the derivation of a bile salt monomeric hydrophobicity index that quantitatively defines the composite hydrophilic-hydrophobic balance of a mixture of bile salts. The index is based on the logarithms of bile salt capacity factors
Externí odkaz:
https://doaj.org/article/f9e1034feadd49659685598d04544976
Autor:
D. M. Heuman
Publikováno v:
Liver Cirrhosis: From Pathophysiology to Disease Management ISBN: 9781402086557
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96cb828aac32847c164908914a73a836
https://doi.org/10.1007/978-1-4020-8656-4_29
https://doi.org/10.1007/978-1-4020-8656-4_29
Autor:
D M, Heuman
Publikováno v:
The Italian journal of gastroenterology. 27(7)
We present evidence that ursodeoxycholate prevents toxicity of more hydrophobic bile salts by inhibiting micellar solubilization of membrane lipids. Using both centrifugal ultrafiltration and gel filtration methods we studied leakage of inulin from v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c24f85b8cae0919e4184890a7d70ea52
https://pubmed.ncbi.nlm.nih.gov/8563009
https://pubmed.ncbi.nlm.nih.gov/8563009
Publikováno v:
Hepatology (Baltimore, Md.). 19(4)
Cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in the bile acid synthesis pathway, is down-regulated by taurocholate by way of negative feedback control at the level of gene transcription. The molecular basis of regulation of cholesterol 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::763cf996a528f6e2066684dcc4a54d0f
https://pubmed.ncbi.nlm.nih.gov/8138269
https://pubmed.ncbi.nlm.nih.gov/8138269
Publikováno v:
Hepatology (Baltimore, Md.). 18(3)
Cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in the bile acid biosynthetic pathway, is thought to be regulated by hydrophobic bile acids through negative feedback control. The role of cholesterol in the regulation of cholesterol 7 alpha-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58c9ede0956b6ba7668a365f9c82f11d
https://pubmed.ncbi.nlm.nih.gov/8359807
https://pubmed.ncbi.nlm.nih.gov/8359807
Autor:
R T, Stravitz, P B, Hylemon, D M, Heuman, L R, Hagey, C D, Schteingart, H T, Ton-Nu, A F, Hofmann, Z R, Vlahcevic
Publikováno v:
The Journal of biological chemistry. 268(19)
The role of bile acids in the regulation of cholesterol 7 alpha-monooxygenase (EC 1.14.13.17) was characterized using primary cultures of rat hepatocytes supplemented with dexamethasone and thyroxine. Taurocholate and taurodeoxycholate (50 microM) re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89bf63114a6867861dee9f4e1f50d240
https://pubmed.ncbi.nlm.nih.gov/8314765
https://pubmed.ncbi.nlm.nih.gov/8314765