Výsledky vyhledávání

Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts

Autor: K Pechhold, N B Patterson, N Craighead, K P Lee, C H June, D M Harlan

Publikováno v: The Journal of Immunology. 158:4921-4929

Optimal T cell activation requires signals delivered via both the TCR and the costimulatory receptors. Considerable experimental data now suggest that this costimulatory signal is generated predominantly by CD28 when engaged by its ligands CD80 (B7-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8764e853e72edd2b63ee99b1bc4c80f2
https://doi.org/10.4049/jimmunol.158.10.4921

Zobrazit plný text záznamu

Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig

Autor: B Saha, B Jaklic, D M Harlan, G S Gray, C H June, R Abe

Publikováno v: The Journal of Immunology. 157:3869-3875

Lethal toxic shock syndrome (TSS) results from the MHC class II presentation of bacterial superantigens, most commonly toxic shock syndrome-1 (TSST-1), to specific TCR Vbeta-bearing T cells. This superantigen-induced stimulation of whole T cell subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::523e85504ff46ff3a43db5278817ecfb
https://doi.org/10.4049/jimmunol.157.9.3869

Zobrazit plný text záznamu

Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation

Autor: D K, Tadaki, A, Williams, K P, Lee, A D, Kirk, D M, Harlan

Publikováno v: Xenotransplantation. 10(3)

Previous studies has shown that human anti-pig reactivity in mixed lymphocyte cultures require the indirect presentation of antigens by human antigen presenting cells (APC). Xenoreactivity was inhibited by blockade of human costimulatory molecules. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4fa01951542d24f252fd1b41c76b4cf9
https://pubmed.ncbi.nlm.nih.gov/12694545

Zobrazit plný text záznamu

Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates

Autor: S P, Montgomery, D A, Hale, B, Hirshberg, D M, Harlan, A D, Kirk

Publikováno v: Immunological reviews. 183

Non-human primate studies of tolerance induction strategies in solid organ transplantation represent a critical bridge between studies in rodents and humans. Our work demonstrates that strategies involving the blockade of co-stimulatory molecules, es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6376ce878b8d39cffefec38b62dbdc24
https://pubmed.ncbi.nlm.nih.gov/11782259

Zobrazit plný text záznamu

Human platelets activate porcine endothelial cells through a CD154-dependent pathway

Autor: H, Xu, F, Arnaud, D K, Tadaki, L C, Burkly, D M, Harlan, A D, Kirk

Publikováno v: Transplantation. 72(11)

Delayed xenograft rejection is associated with endothelial cell activation, platelet sequestration, and subsequent thrombosis. We evaluated whether human platelets could directly activate porcine endothelium (PEC), and if so, whether this was mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::718b2f5a9c5c82dff17e757a75b9b6fd
https://pubmed.ncbi.nlm.nih.gov/11740405

Zobrazit plný text záznamu

Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates

Autor: E A, Elster, H, Xu, D K, Tadaki, S, Montgomery, L C, Burkly, J D, Berning, R E, Baumgartner, F, Cruzata, R, Marx, D M, Harlan, A D, Kirk

Publikováno v: Transplantation. 72(9)

Allogeneic skin transplantation remains a rigorous test of any immune intervention designed to prevent allograft rejection. To date, no single, clinically available immunosuppressant has been reported to induce long-term primary skin allograft surviv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c74fad8dfe8bf7c07cc1e70b87fbc93
https://pubmed.ncbi.nlm.nih.gov/11707732

Zobrazit plný text záznamu

Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes

Autor: S C, Hoffmann, E M, Stanley, E, Darrin Cox, N, Craighead, B S, DiMercurio, D E, Koziol, D M, Harlan, A D, Kirk, P J, Blair

Publikováno v: Transplantation. 72(8)

Genetic variations in cytokine genes are thought to regulate cytokine protein production. However, studies using T cell mitogens have not always demonstrated a significant relationship between cytokine polymorphisms and in vitro protein production. F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49304a28e228dca4c0cecd281f695cb1
https://pubmed.ncbi.nlm.nih.gov/11685118

Zobrazit plný text záznamu

Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates

Autor: A D, Kirk, D K, Tadaki, A, Celniker, D S, Batty, J D, Berning, J O, Colonna, F, Cruzata, E A, Elster, G S, Gray, R L, Kampen, N B, Patterson, P, Szklut, J, Swanson, H, Xu, D M, Harlan

Publikováno v: Transplantation. 72(3)

CD80 and CD86 (also known as B7-1 and B7-2, respectively) are both ligands for the T cell costimulatory receptors CD28 and CD152. Both CD80 and CD86 mediate T cell costimulation, and as such, have been studied for their role in promoting allograft re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ab0edd2ed34a8790fb370f515446b41
https://pubmed.ncbi.nlm.nih.gov/11502964

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání