Výsledky vyhledávání

Acceptability of a first-line anti-tuberculosis formulation for children: qualitative data from the SHINE trial

Autor: D. T. Wademan, L. Busakwe, T. J. Nicholson, M. van der Zalm, M. Palmer, J. Workman, A. Turkova, A. M. Crook, M. J. Thomason, D. M. Gibb, J. Seeley, A. Hesseling, G. Hoddinott, null on behalf of the SHINE trial team

Publikováno v: The International Journal of Tuberculosis and Lung Disease

SETTING: We conducted a qualitative exploration into the palatability and acceptability of a novel fixed-dose combination (FDC) anti-tuberculosis drug. This study was nested in the SHINE (Shorter treatment for minimal TB in children) trial, which com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941fb618424b3d784314aa4a7bd42b39
https://doi.org/10.5588/ijtld.19.0115

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Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial

Autor: Elizabeth C. George, Britta C. Urban, David M. Burger, Roisin Connon, D M Gibb, Thomas N. Williams, Ayub Mpoya, Kathryn Maitland, Sophie Uyoga, Rita Muhindo, Hellen Mnjalla, William Okiror, A S Walker, Peter Olupot-Olupot, R terHeine

Publikováno v: Wellcome Open Research. 6:161

Background: African children with severe malaria are susceptible to Gram-negative bacterial co-infection, largely non-typhoidal Salmonellae, leading to a substantially higher rates of in-hospital and post-discharge mortality than those without bacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ffd984e966b9316b6c74f5db13307e3
https://doi.org/10.12688/wellcomeopenres.16968.1

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Who Gets Severe Gynecomastia Among HIV-infected Children in the United Kingdom and Ireland?

Autor: D M Gibb, Katja Doerholt, Ali Judd, Julia Kenny

Publikováno v: Pediatric Infectious Disease Journal. 36:307-310

There are few data on gynecomastia in HIV-infected children. Within the UK/Ireland’s national cohort, 56 of 1873 (3%) HIV-infected children had gynecomastia, of which 10 (0.5%) were severe. All 10 had received antiretroviral therapy for a median of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fcb571f145743b91520801c5884c277
https://doi.org/10.1097/inf.0000000000001424

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G265(P) Gastroenteritis aggressive versus slow treatment for rehydration (gastro study): a descriptive analysis

Autor: Elizabeth C George, D M Gibb, Kathryn Maitland, Nchafatso G. Obonyo, Peter Olupot-Olupot, Ayub Mpoya, Jack G. Gibb, Kirsty A. Houston

Publikováno v: International Child Health Group.

Aims The World Health Organisation (WHO) rehydration guidelines (Plan C) for children with acute gastroenteritis (AGE) and severe dehydration are widely practiced in resource-poor settings, yet have never been evaluated in a clinical trial. GASTRO st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76ba393cd589c13c2e5ad7f81a50ad4a
https://doi.org/10.1136/archdischild-2018-rcpch.258

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Pharmacokinetics of antiretroviral drug varies with formulation in the target population of children with HIV-1

Autor: P, Kasirye, L, Kendall, K K, Adkison, C, Tumusiime, M, Ssenyonga, S, Bakeera-Kitaka, P, Nahirya-Ntege, T, Mhute, A, Kekitiinwa, W, Snowden, D M, Burger, D M, Gibb, A S, Walker, G, Ndeezi

Publikováno v: Clinical Pharmacology and Therapeutics, 91, 272-80
Clinical Pharmacology and Therapeutics, 91, 2, pp. 272-80

Item does not contain fulltext The bioequivalence of formulations is usually evaluated in healthy adult volunteers. In our study in 19 HIV-1-infected Ugandan children (1.8-4 years of age, weight 12 to /=24 weeks, the use of scored tablets allowed com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a66fdd347efee902478875de78da106
https://doi.org/10.1038/clpt.2011.225

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Early antiretroviral treatment reduces risk of bacille Calmette-Guérin immune reconstitution adenitis

Autor: H. Rabie, A. Violari, T. Duong, S. A. Madhi, D. Josipovic, S. Innes, E. Dobbels, E. Lazarus, R. Panchia, A. G. Babiker, D. M. Gibb, M. F. Cotton, null CHER team

Publikováno v: The International Journal of Tuberculosis and Lung Disease. 15:1194-1200

Two centres in Soweto and Cape Town, South Africa.To assess the effects of timing of initiation of antiretroviral treatment (ART) and other factors on the risk of bacille Calmette-Guérin (BCG) related regional adenitis due to immune reconstitution i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89cbb366315df8607658768d0b661cf
https://doi.org/10.5588/ijtld.10.0721

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Nevirapine/zidovudine/lamivudine has superior immunological and virological responses not reflected in clinical outcomes in a 48-week randomized comparison with abacavir/zidovudine/lamivudine in HIV-infected Ugandan adults with low CD4 cell counts

Autor: P, Munderi, A S, Walker, C, Kityo, A G, Babiker, F, Ssali, A, Reid, J H, Darbyshire, H, Grosskurth, P, Mugyenyi, D M, Gibb, C F, Gilks, E, Katabira

Publikováno v: HIV Medicine. 11:334-344

BACKGROUND: Triple nucleoside reverse transcriptase inhibitor regimens have advantages as first-line antiretroviral therapy (ART), avoiding hepatotoxicity and interactions with anti-tuberculosis therapy, and sparing two drug classes for second-line A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d65de4173db46673791382f9d3eb47
https://doi.org/10.1111/j.1468-1293.2009.00786.x

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Effect of tenofovir disoproxil fumarate on risk of renal abnormality in HIV-1-infected children on antiretroviral therapy: a nested case–control study

Autor: D M Gibb, Andrew Riordan, Mike Sharland, Delane Shingadia, Karina Butler, David Dunn, Wolfgang Stöhr, Hermione Lyall, Katherine Boyd, Ali Judd

Publikováno v: AIDS. 24:525-534

Objective: To investigate the association between tenofovir disoproxil fumarate (TDF) use and renal abnormality in a large cohort of HIV-1-infected children on antiretroviral therapy (ART). Design: Nested case-control study. Methods: Patients were fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb0d8a1d8272d8c7a937a058ef29e28
https://doi.org/10.1097/qad.0b013e3283333680

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