Výsledky vyhledávání - "D M, Essayan"

Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors

Autor: D M Essayan, S K Huang, B J Undem, A Kagey-Sobotka, L M Lichtenstein

Publikováno v: The Journal of Immunology. 153:3408-3416

Cyclic nucleotide phosphodiesterase (PDE) enzymes are felt to play a role in the regulation of inflammatory responses through their effects on cAMP. In this study, we investigated the effects of nonselective and isozyme selective PDE inhibitors on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34a915bc6dbbbd5c58f44d4215b0561f
https://doi.org/10.4049/jimmunol.153.8.3408

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Profiling of differential gene expression in activated, allergen-specific human Th2 cells

Autor: Mark C. Liu, D. M. Essayan, Shau Ku Huang, X. D. Li, T.H. Beaty

Publikováno v: Genes and immunity. 2(2)

Th2 cells play a pivotal role in the pathogenesis of allergic diseases, including asthma, but the molecular basis of the Th1/Th2 dichotomy and the precise molecular pathways leading to Th2-dominant immune responses are still unclear. To this end, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8372a9643c65eb80ed1b65e6cfa05a7a
https://pubmed.ncbi.nlm.nih.gov/11393662

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Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts

Autor: A, Oriente, N S, Fedarko, S E, Pacocha, S K, Huang, L M, Lichtenstein, D M, Essayan

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(3)

Interleukin (IL)-13 has been implicated in the pathogenesis of various diseases characterized by fibrosis. We describe the effects of IL-13 on collagen homeostasis from normal (NF) and keloid (KF) fibroblasts and compare these effects with those of I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5940fc3d990d2cd7d0e37f294490a13a
https://pubmed.ncbi.nlm.nih.gov/10688614

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Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

Autor: C D, Manning, M, Burman, S B, Christensen, L B, Cieslinski, D M, Essayan, M, Grous, T J, Torphy, M S, Barnette

Publikováno v: British journal of pharmacology. 128(7)

1. Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T lymphocytes. We explored the functional role of these subtypes using ten subtype-selective PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c69566b42dceab27980c7f852f155e0
https://pubmed.ncbi.nlm.nih.gov/10602317

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SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions

Autor: M S, Barnette, S B, Christensen, D M, Essayan, M, Grous, U, Prabhakar, J A, Rush, A, Kagey-Sobotka, T J, Torphy

Publikováno v: The Journal of pharmacology and experimental therapeutics. 284(1)

First-generation phosphodiesterase 4 (PDE4) inhibitors, such as rolipram, inhibit the activation of immune and inflammatory cells. The clinical use of these compounds is limited by gastrointestinal side effects, such as increased acid secretion and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0036876e93af76566bd34c5456fe43e7
https://pubmed.ncbi.nlm.nih.gov/9435206

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Modulation of antigen- and mitogen-induced proliferative responses of peripheral blood mononuclear cells by nonselective and isozyme selective cyclic nucleotide phosphodiesterase inhibitors

Autor: D M, Essayan, S K, Huang, B J, Undem, A, Kagey-Sobotka, L M, Lichtenstein

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 153(8)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77d8938cac7ea67984c7e51e6bad1f8c
https://pubmed.ncbi.nlm.nih.gov/7930566

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Limiting dilution analysis of the frequency of antigen-reactive lymphocytes isolated from the central nervous system of Lewis rats with experimental allergic encephalomyelitis

Autor: Jeffrey A. Cohen, Burton Zweiman, D. M. Essayan, Robert P. Lisak

Publikováno v: Cellular Immunology. 108:203-213

Lymphocytes were isolated from the spinal cord and draining lymph nodes of Lewis rats with acute experimental allergic encephalomyelitis (EAE) 12 days after immunization with myelin basic protein (MBP) and tetanus toxoid (TT). An average of 8.0 +/- 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c9a675d52149c8b32a147011a5699c
https://doi.org/10.1016/0008-8749(87)90204-8

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