Zobrazeno 1 - 10
of 18
pro vyhledávání: '"D Lorne J, Tyrrell"'
Autor:
Deanna M. Santer, Daniel Li, Yanal Ghosheh, Muhammad Atif Zahoor, Dhanvi Prajapati, Bettina E. Hansen, D. Lorne J. Tyrrell, Jordan J. Feld, Adam J. Gehring
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The interferon response is a critical component response to SARS-CoV-2 infection and prior studies have established a role for the administration of PEGylated interferon-lambda1 and its impact on viral clearance. Here the authors show that PEGylated
Externí odkaz:
https://doaj.org/article/76aeb35452c84e428bbee3f01d975611
Autor:
Maral Aminpour, Williams Ernesto Miranda Delgado, Soren Wacker, Sergey Noskov, Michael Houghton, D. Lorne J. Tyrrell, Jack A. Tuszynski
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background The emergence and rapid spread of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in thelate 2019 has caused a devastating global pandemic of the severe pneumonia-like disease coronavirus disease 2019 (COVID-19). Alth
Externí odkaz:
https://doaj.org/article/950a279162d149fe991a7933805bb00a
Autor:
Christopher J Neufeldt, Michael A Joyce, Nicholas Van Buuren, Aviad Levin, Karla Kirkegaard, Michael Gale, D Lorne J Tyrrell, Richard W Wozniak
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005428 (2016)
Hepatitis C virus (HCV) is a positive-strand RNA virus of the Flaviviridae family and a major cause of liver disease worldwide. HCV replicates in the cytoplasm, and the synthesis of viral proteins induces extensive rearrangements of host cell membran
Externí odkaz:
https://doaj.org/article/e371c439755b4caf829219a37819686b
Autor:
Deanna M Santer, Daniel Li, Yanal Ghosheh, Muhammad Atif Zahoor, Dhanvi Prajapati, D Lorne J Tyrrell, Jordan J Feld, Adam J Gehring
Interferons (IFNs) are antiviral cytokines induced very early after SARS-CoV-2 infection and are crucial for viral clearance, shaping immunity, and preventing the development of severe COVID-19. We previously demonstrated that a single injection of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::039c51bbe0a2e0f35002f5dde6b15756
https://doi.org/10.1101/2022.02.24.22271438
https://doi.org/10.1101/2022.02.24.22271438
Autor:
Adrian Egli, Deanna M Santer, Daire O'Shea, Khaled Barakat, Mohammedyaseen Syedbasha, Madeleine Vollmer, Aliyah Baluch, Rakesh Bhat, Jody Groenendyk, Michael A Joyce, Luiz F Lisboa, Brad S Thomas, Manuel Battegay, Nina Khanna, Thomas Mueller, D Lorne J Tyrrell, Michael Houghton, Atul Humar, Deepali Kumar
Publikováno v:
PLoS Pathogens, Vol 10, Iss 12, p e1004556 (2014)
Influenza is a major cause of morbidity and mortality in immunosuppressed persons, and vaccination often confers insufficient protection. IL-28B, a member of the interferon (IFN)-λ family, has variable expression due to single nucleotide polymorphis
Externí odkaz:
https://doaj.org/article/e2194a232ce34ee199f89538bd63f25d
Autor:
Aviad Levin, Christopher J Neufeldt, Daniel Pang, Kristen Wilson, Darci Loewen-Dobler, Michael A Joyce, Richard W Wozniak, D Lorne J Tyrrell
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114629 (2014)
The hepatitis C virus (HCV) is a positive strand RNA virus of the Flavivirus family that replicates in the cytoplasm of infected hepatocytes. Previously, several nuclear localization signals (NLS) and nuclear export signals (NES) have been identified
Externí odkaz:
https://doaj.org/article/5d002d0a2ea9436b95b25bdfd6aec9ef
Autor:
Christopher J Neufeldt, Michael A Joyce, Aviad Levin, Rineke H Steenbergen, Daniel Pang, Justin Shields, D Lorne J Tyrrell, Richard W Wozniak
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003744 (2013)
Hepatitis C virus (HCV) infection induces formation of a membranous web structure in the host cell cytoplasm where the viral genome replicates and virions assemble. The membranous web is thought to concentrate viral components and hide viral RNA from
Externí odkaz:
https://doaj.org/article/7851f7daa63845588bf05888929debcd
Autor:
Deanna M Santer, Mang M Ma, Darren Hockman, Abdolamir Landi, D Lorne J Tyrrell, Michael Houghton
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68308 (2013)
Mixed cryoglobulinemia is the most common extrahepatic disease manifestation of chronic hepatitis C virus (HCV) infection, where immunoglobulins precipitate at low temperatures and cause symptoms such as vasculitis, glomerulonephritis and arthralgia.
Externí odkaz:
https://doaj.org/article/4e8b3799768145b0aa47aa4d8aefcc29
Autor:
Yutaka Takebe, Carrie J Saucedo, Garry Lund, Rie Uenishi, Saiki Hase, Takayo Tsuchiura, Norman Kneteman, Koreen Ramessar, D Lorne J Tyrrell, Masayuki Shirakura, Takaji Wakita, James B McMahon, Barry R O'Keefe
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64449 (2013)
Hepatitis C virus (HCV) infection is a significant public health problem with over 170,000,000 chronic carriers and infection rates increasing worldwide. Chronic HCV infection is one of the leading causes of hepatocellular carcinoma which was estimat
Externí odkaz:
https://doaj.org/article/c8a6cc18c5d049bf83106bd356cfc590
Autor:
Donna N Douglas, Toshiyasu Kawahara, Banu Sis, David Bond, Karl P Fischer, D Lorne J Tyrrell, Jamie T Lewis, Norman M Kneteman
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9209 (2010)
Severe Combined Immune Deficient (SCID)/Urokinase-type Plasminogen Activator (uPA) mice undergo liver failure and are useful hosts for the propagation of transplanted human hepatocytes (HH) which must compete with recipient-derived hepatocytes for re
Externí odkaz:
https://doaj.org/article/e1e6034a20a5471fbd9a5e0ef3376ba4