Zobrazeno 1 - 10
of 93
pro vyhledávání: '"D Lincová"'
UREA SYNTHESIS AND CYCLOSPORIN A BIOTRANSFORMATION IN A LABORATORY SCALE HEPATOCYTE BIOREACTOR MODEL
Publikováno v:
Pharmacological Research. 46:511-517
Inefficient oxygenation and build-up of waste products are inevitable in a conventional cell culture. The development of a perifusion method for isolated hepatocytes improves the process of oxygenation and helps in end-product removal. For the perifu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6017481dc2edf2a6ee078b48cdafc90
https://doi.org/10.1016/s1043661802002347
https://doi.org/10.1016/s1043661802002347
Publikováno v:
Physiological research. 54(4)
Though two isoforms of nitric oxide synthase, iNOS and eNOS, were reported in adipocytes, the role of NO in adipose tissue is still ambiguous. The aims of the present study were 1) to follow the effect of bacterial lipopolysaccharide (LPS), on 24 h-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6665bc8a619e9983a6bf8066d626a9c8
https://pubmed.ncbi.nlm.nih.gov/15588153
https://pubmed.ncbi.nlm.nih.gov/15588153
Publikováno v:
Physiological research. 51(4)
The present investigation was directed to study the effect of in vitro or ex vivo NO donors, sodium nitroprusside and molsidomine, using isolated sliced adipose tissue or in the form of immobilized and perfused adipocytes on the basal and isoprenalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fd463d125fb085a594db37cbd1e774f
https://pubmed.ncbi.nlm.nih.gov/12449437
https://pubmed.ncbi.nlm.nih.gov/12449437
Publikováno v:
Physiological research. 43(2)
This study deals with the application of the previously developed immobilized and perfused isolated hepatocytes as a cellular system for the study of representative phase I and phase II of biotransformation reactions. To illustrate phase I reactions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d2eccd8da1df38de3671fdfb0dd34a7
https://pubmed.ncbi.nlm.nih.gov/7918338
https://pubmed.ncbi.nlm.nih.gov/7918338
Publikováno v:
Physiological research. 43(2)
The method of cellular immobilization and perfusion was applied to adipocytes. The lipolytic effect of isoprenaline, whose action is produced as a result of receptor-drug interaction, was followed. An agarose solution kept at at 37 degrees C was mixe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5295d18687f0840dce53cfa3ee171dc
https://pubmed.ncbi.nlm.nih.gov/7918340
https://pubmed.ncbi.nlm.nih.gov/7918340
Publikováno v:
Physiological research. 43(2)
In the present study, a method has been employed for hepatocyte immobilization in agarose threads which allows for cell perfusion. The rat hepatocytes are isolated from the liver. A 1.8% low-gelling agarose solution is prepared in warm Krebs-Henselei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::715d979af69e3e67421c22a0314f6215
https://pubmed.ncbi.nlm.nih.gov/7918337
https://pubmed.ncbi.nlm.nih.gov/7918337
Publikováno v:
Sbornik lekarsky. 94(1)
The effect of ascorbic acid on basal and adrenergic lipolysis was studied in rat epididymal adipose tissue in vitro. When adipose tissue was incubated with isoprenaline (ISO) for 1.5 h, the concentration-lipolytic effect curves of ISO were practicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77721d83f1de749a82fdf48dc47a0884
https://pubmed.ncbi.nlm.nih.gov/7991999
https://pubmed.ncbi.nlm.nih.gov/7991999
Publikováno v:
Sbornik lekarsky. 93(9-10)
It is now generally accepted, that in most of the animal species the adrenergic control of lipolysis from adipose tissue is mediated by adrenergic beta 1 and alpha 2 receptors. Therefore, the problem we deal with in this article is concerned with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d90b7ef680aadc8f05343f5dba5734cf
https://pubmed.ncbi.nlm.nih.gov/1687969
https://pubmed.ncbi.nlm.nih.gov/1687969
Publikováno v:
Sbornik lekarsky. 93(3-4)
On a simple model of a reaction-chain from the pharmacon-receptor complex (RA) formation the formation of a ternal complex with substrate (S) and its activation to a product the authors investigate the meaning of the term "affinity" and "internal act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1093dbdfd8fd114cdea4f0f650938453
https://pubmed.ncbi.nlm.nih.gov/1853140
https://pubmed.ncbi.nlm.nih.gov/1853140
Publikováno v:
Sbornik lekarsky. 92(6-7)
Two different subpopulations of adrenergic alpha-receptors -- "high-affinity" (pD2 less than 8) and "low-affinity" (pD2 less than 6) ones -- are involved in alpha-adrenergic contractions of the rat spleen muscle evoked by noradrenaline in vitro. Only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83fe1bdfd60e048ebe35bf1deded73cb
https://pubmed.ncbi.nlm.nih.gov/2173128
https://pubmed.ncbi.nlm.nih.gov/2173128