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Immunomodulation in Type 1 Diabetes by NBI-6024, an Altered Peptide Ligand of the Insulin B(9-23) Epitope

Autor: D. L. Simmons, Peter A. Gottlieb, A. L. Putnam, J. M. Robinson, Richard A. Maki, P. Dandona, Jennifer B. Marks, David G. Alleva, Paul J. Conlon, R. G. Jimenez, M. S. Kipnes, Carla J. Greenbaum

Publikováno v: Scandinavian Journal of Immunology. 63:59-69

NBI-6024 is an altered peptide ligand (APL) corresponding to the 9–23 amino acid region of the insulin B chain (B(9−23)), an epitope recognized by inflammatory interferon-γ-producing T helper (Th)1 lymphocytes in type 1 diabetic patients. Immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ce7bf461f286d7ff1865f91c80e7e66
https://doi.org/10.1111/j.1365-3083.2005.01705.x

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Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95

Autor: Suet-Mien Tan, S. K. A. Law, L. A. Boxer, Sarah L. Scarth, Dirk Roos, D. L. Simmons, Christopher D. Buckley, S. M. Nolan, Jacqueline Shaw, Nigel Klein, Aymen Al-Shamkhani, Irene Roberts, A. W. Dodds

Publikováno v: Clinical and Experimental Immunology. 126:311-318

SummaryLeucocyte adhesion deficiency (LAD) is a hereditary disorder caused by mutations in the CD18 (β2 integrin) gene. Four missense mutations have been identified in three patients. CD18(A270V) supports, at a diminished level, CD11b/CD18 (Mac-1, �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d114b863c26909994ba529b3ecd3afc1
https://doi.org/10.1046/j.1365-2249.2001.01661.x

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CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPα 1

Autor: A N Barclay, W J Kee, D L Simmons, E F Vernon-Wilson, Marion H. Brown, Antony C. Willis

Publikováno v: European Journal of Immunology. 30:2130-2137

The rat OX41 antigen is a cell surface protein containing three immunoglobulin superfamily domains and intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM). It is a homologue of the human signal-regulatory protein (SIRP) also known as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25adefea7772fea57e1bd3da8cfcf522
https://doi.org/10.1002/1521-4141(2000)30:8<2130::aid-immu2130>3.0.co

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Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer

Autor: D. C. Gotley, Jonathan Fawcett, T. M. Antalis, Michael Walsh, Jennifer A. Reeder, D. L. Simmons

Publikováno v: British Journal of Cancer

Increased expression of alternatively spliced variants of the CD44 family of cell adhesion molecules has been associated with tumour metastasis. In the present study, expression of alternatively spliced variants of CD44 and their cellular distributio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d8abdcf39b3fee9e44efd5f0f056f6
https://doi.org/10.1038/bjc.1996.364

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Glycaemia and correlates of patient-reported outcomes in ACCORD trial participants

Autor: M K, Ali, P, Feeney, D, Hire, D L, Simmons, P J, O'Connor, F, Ganz-Lord, D, Goff, P, Zhang, R T, Anderson, K M V, Narayan, M D, Sullivan

Publikováno v: Diabetic medicine : a journal of the British Diabetic Association. 29(7)

Post-hoc evaluation of relationships between first-year change in glycaemic control (HbA(1c) ) and change in patient-reported outcomes among ACCORD health-related quality of life (HRQoL) substudy participants.Data from 2053 glycaemia-trial subjects w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77ee86a789044a1d1c9c811e050e35da
https://pubmed.ncbi.nlm.nih.gov/22141437

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Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions

Autor: L. Ø. Levy, Jo Anne S. Richards, J Sirois, D. L. Simmons

Publikováno v: Journal of Biological Chemistry. 268:12199-12206

Prostaglandin endoperoxide synthase isoform 2 (PGS-2) mRNA and protein are transiently induced by gonadotropins in granulosa cells of preovulatory follicles prior to ovulation. To better understand the hormonal regulation of the rat PGS-2 (rPGS-2) ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d656fee645540f351cca9cdb887a99
https://doi.org/10.1016/s0021-9258(19)50326-x

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Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro

Autor: D. L. Simmons, J Sirois, JoAnne S. Richards

Publikováno v: Journal of Biological Chemistry. 267:11586-11592

Recent purification and amino-terminal analysis of the isoform of prostaglandin endoperoxide H synthase (PGS) induced in rat preovulatory follicles by gonadotropins identified it as a novel distinct isoform of PGS (rPGSi) which exhibited a high degre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f80f6b31928ce3a40a3d439a27d4b11f
https://doi.org/10.1016/s0021-9258(19)49951-1

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Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells

Autor: D L Simmons, A B Satterthwaite, D G Tenen, B Seed

Publikováno v: The Journal of Immunology. 148:267-271

CD34 is a 115-kDa transmembrane glycoprotein of unknown function that is expressed on human hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. We have isolated a CD34 cDNA clone from a KG-1 cell library following

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31efd118919e658e16c70b376c3c0c1f
https://doi.org/10.4049/jimmunol.148.1.267

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Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope

Autor: D G, Alleva, R A, Maki, A L, Putnam, J M, Robinson, M S, Kipnes, P, Dandona, J B, Marks, D L, Simmons, C J, Greenbaum, R G, Jimenez, P J, Conlon, P A, Gottlieb

Publikováno v: Scandinavian journal of immunology. 63(1)

NBI-6024 is an altered peptide ligand (APL) corresponding to the 9-23 amino acid region of the insulin B chain (B(9-23)), an epitope recognized by inflammatory interferon-gamma-producing T helper (Th)1 lymphocytes in type 1 diabetic patients. Immunom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da9ac9612f7436ed2262c814bfa8e675
https://pubmed.ncbi.nlm.nih.gov/16398702

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Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin

Autor: M U, Chaudhry, D L, Simmons

Publikováno v: The Journal of the Arkansas Medical Society. 98(1)

Troglitazone is a thiazolidinedione with insulin-sensitizing activities when administered to humans or animals with type 2 diabetes mellitus. It has been shown to have numerous desirable metabolic effects on glucose and lipid metabolism. A major adve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c69bcf51a64277b71f557bb3f49a3ed3
https://pubmed.ncbi.nlm.nih.gov/11452755

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