Výsledky vyhledávání - "D L Kirkpatrick"

Structure-Based Drug Design: Combinatorial Chemistry and Molecular Modeling

Autor: D L, Kirkpatrick, S, Watson, S, Ulhaq

Publikováno v: Combinatorial Chemistry & High Throughput Screening. 2:211-221

Abstract: Drug discovery efforts are shifting to include the rapid synthetic procedures of combinatorial chemistry and the elegance of rational library design. The wealth of computational methods which explore both the receptor structure and the ulti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51fc427e8c8d0c22b1cbc7be0d231c75
https://doi.org/10.2174/1386207302666220204193511

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Redox Control as a Target for Anticancer Drug Development

Autor: D. L. Kirkpatrick

Publikováno v: Current Pharmaceutical Design. 3:305-322

Abstract: Cells maintain an intracellular environment that is reducing in the face of an oxidizing extracellular environment. Regulated alterations in the intracellular redox state (redox signalling) can modulate events such as DNA synthesis, enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e227398e4467b69e68469820f9fe436c
https://doi.org/10.2174/138161280303221007124918

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A phase IB trial of 24-hour intravenous PX-12, a Thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers

Autor: H. H. S. Chow, K. N. Adab, D. L. Kirkpatrick, Steven P. Stratton, M. Boice, Natarajan Raghunand, S. W. Squire, Linda Pestano, Tomislav Dragovich, Amanda F. Baker

We investigated the safety, pharmacokinetics, and pharmacodynamics of PX-12, a thioredoxin-1 (Trx-1) inhibitor, administered as a 24-hour infusion every 7 or 14 days in patients with gastrointestinal malignancies. PX-12 is the first Trx-1 inhibitor t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551bf7c885f71d8f1358668535affe12
https://europepmc.org/articles/PMC3988981/

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ChemInform Abstract: Redox Control as a Target for Anticancer Drug Development

Autor: D. L. Kirkpatrick

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5028ee224fa86d229d440c4286ba0532
https://doi.org/10.1002/chin.199747300

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Synthesis and Cytotoxic Evaluation of Some 6-Arylidene-2-(α-hydroxyamino-α-arylmethyl)cyclohexanone Oximes and Related Compounds

Autor: Jonathan R. Dimmock, Zongchao Jia, L. Zhu, M. J. Duffy, K. K. Sidhu, D. L. Kirkpatrick, S. M. Fletcher, R. S. Reid, J. W. Quail

Publikováno v: Journal of Pharmaceutical Sciences. 81:1059-1064

Reaction of 2,6-bis-(phenylmethylene)cyclohexanone (1) with a 4-molar excess of hydroxylamine hydrochloride and sodium acetate to produce the corresponding oxime 2 gave rise to 2-(alpha-hydroxyamino-alpha-phenylmethyl)-6-phenylmethylenecyclohexan one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2587348a8e46b8155690269536d8b8f
https://doi.org/10.1002/jps.2600811103

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Chemosensitivity testing of fresh human leukemia cells using both a dye exclusion assay and a tetrazolium dye (MTT) assay

Autor: M Duke, D L Kirkpatrick, T S Goh

Publikováno v: Leukemia Research. 14:459-466

Chemosensitivity testing using a DEA was performed on 91 leukemia samples from 70 patients with leukemia. In 55 patients, comparison of in-vitro results with actual response of the patient was made. There was good correlation in 82% of the cases, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01730196edf6a33816c4bff00195c896
https://doi.org/10.1016/0145-2126(90)90033-6

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Utilization of distillers dried grains with solubles and phytase in sow lactation diets to meet the phosphorus requirement of the sow and reduce fecal phosphorus concentration

Autor: G M, Hill, J E, Link, M J, Rincker, D L, Kirkpatrick, M L, Gibson, K, Karges

Publikováno v: Journal of animal science. 86(1)

Two experiments were completed to determine the potential for using distillers dried grains with solubles (DDGS) in diets with or without phytase to provide available P, energy, and protein to highly productive lactating sows without increasing their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cac9182b1d8bfce923ee42caecf9fbdc
https://pubmed.ncbi.nlm.nih.gov/17878284

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Parallel syntheses of disulfide inhibitors of the thioredoxin redox system as potential antitumor agents

Autor: D L, Kirkpatrick, S, Watson, M, Kunkel, S, Fletcher, S, Ulhaq, G, Powis

Publikováno v: Anti-cancer drug design. 14(5)

We have reported previously that unsymmetrical disulfide inhibitors of the human thioredoxin/thioredoxin reductase redox system (hTrx/TR) possess antitumor activity. We have broadened the search for more potent inhibitors and evaluated a large range

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2d7d1ab8b7334db136dc6e74946d1df
https://pubmed.ncbi.nlm.nih.gov/10766297

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Cell line-directed screening assay for inhibitors of thioredoxin reductase signaling as potential anti-cancer drugs

Autor: M W, Kunkel, D L, Kirkpatrick, J I, Johnson, G, Powis

Publikováno v: Anti-cancer drug design. 12(8)

We have used a cell line-directed screening approach (CDSA) to identify novel inhibitors of the thioredoxin reductase signaling pathway which contributes to the transformed phenotype of some human tumors. Two 2-imidazolyl disulfide compounds, previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4ea315eb0ea1c7ca289ee3fbcb9a4c1
https://pubmed.ncbi.nlm.nih.gov/9448705

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