Zobrazeno 1 - 10 of 119 pro vyhledávání: '"D L Hughes"'
1
Development of a Kilogram-Scale Asymmetric Synthesis of a Potent DP Receptor Antagonist
Autor: Peter E. Maligres, Bob Reamer, Cecile G. Savarin, Guy R. Humphrey, Matthew T. Tudge, Katherine DiFelice, David M. Tellers, D. L. Hughes
Publikováno v: Organic Process Research & Development. 14:787-798
An efficient asymmetric synthesis of a unique sulfenylated prostaglandin DP receptor antagonist candidate is described. The synthesis is characterized by a novel intramolecular Friedel−Crafts cyclization of an imino-pyrrole to prepare the azaindole
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bb3ebeb641a62cc3849869a7d9945b4
https://doi.org/10.1021/op100008m
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2
Direct N-Acetyl Enamine Formation: Lithium Bromide Mediated Addition of Methyllithium to Nitriles
Autor: Jerry A. Murry, Genevieve N. Boice, Edward G. Corley, Cecile G. Savarin, Lisa DiMichele, D. L. Hughes
Publikováno v: Organic Letters. 8:3903-3906
An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. The resulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3daa7ce6233abf8b5b9c4b8d9db6173
https://doi.org/10.1021/ol061318k
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3
An efficient synthesis of a highly functionalized 4-arylpiperidine
Autor: Karen M. Conrad, Edward G. Corley, D. L. Hughes, Jacqueline H. Smitrovich, Jerry A. Murry, Genevieve N. Boice, Cecile G. Savarin, Louis Matty
Publikováno v: Tetrahedron. 60:11367-11374
In this manuscript, an efficient synthesis of a functionalized 4-arylpiperidine is disclosed. Several synthetic approaches towards formation of the key aryl-piperidine sp3 carbon–carbon bond are discussed, including a scalable route to the piperidi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::830d1653f8f194f3a602a9e36bfe661a
https://doi.org/10.1016/j.tet.2004.09.092
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9
A Mild and Efficient Synthesis of 4-Quinolones and Quinolone Heterocycles
Autor: Cheng-yi Chen, Peter G. Dormer, Curtis Deer, D. L. Hughes, Daniel Zewge
Publikováno v: ChemInform. 38
The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditional
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a51c653d7794b42867def6800a57d4
https://doi.org/10.1002/chin.200739133
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10
Direct N-Acetyl Enamine Formation: Lithium Bromide Mediated Addition of Methyllithium to Nitriles
Autor: Lisa DiMichele, D. L. Hughes, Jerry A. Murry, Genevieve N. Boice, Edward G. Corley, Cecile G. Savarin
Publikováno v: ChemInform. 38
An improved protocol for N-acetyl enamine formation is disclosed which involves LiBr-mediated addition of MeLi to substituted nitriles. The resulting enamides are isolated in high yields and excellent purity which permits subsequent hydrogenation at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0444817496283a334da809704339b146
https://doi.org/10.1002/chin.200702059
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