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Abstract P4-15-12: Rebastinib in combination with eribulin ablates TIE2-expressing macrophages, reduces metastasis, and increases survival in the PyMT metastatic breast cancer model

Autor: Cynthia B. Leary, W.P. Lu, Berger, Benjamin A. Turner, Bryan D. Smith, Subha Vogeti, Molly M. Hood, Scott C. Wise, D L Flynn, Kaufman

Publikováno v: Cancer Research. 73:P4-15

In cancer models, TIE2 kinase plays an important role in angiogenesis, vasculogenesis, and tumor metastasis. TIE2 expression is largely restricted to vascular endothelial cells, tissue macrophages, and bone marrow derived TIE2-expressing monocytes (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2f74465441ceb68ea1ce9c87cb69cd5
https://doi.org/10.1158/0008-5472.sabcs13-p4-15-12

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Targeting the KIT activating switch control pocket: a novel mechanism to inhibit neoplastic mast cell proliferation and mast cell activation

Autor: Dean D. Metcalfe, E Ching Chan, Alasdair M. Gilfillan, D L Flynn, Olga Simakova, Todd M. Wilson, S N Bandara, Yun Bai, Geethani Bandara, W.P. Lu, Irina Maric, Scott C. Wise

Publikováno v: Leukemia

Activating mutations in the receptor tyrosine kinase KIT, most notably KIT D816V, are commonly observed in patients with systemic mastocytosis. Thus, inhibition of KIT has been a major focus for treatment of this disorder. Here we investigated a nove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979bd859489f071be5ae210e565f3d95
https://doi.org/10.1038/leu.2012.218

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Phase-trafficking reagents and phase-switching strategies for parallel synthesis

Autor: D L, Flynn

Publikováno v: Medicinal research reviews. 19(5)

Strategies for the parallel synthesis of small molecule arrays are reviewed with an emphasis on those approaches that integrate the sciences of organic synthesis and product purification. The use of phase-trafficking reagents (PTRs) and phase-switchi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dea39d6d85941cf8596a229af6085238
https://pubmed.ncbi.nlm.nih.gov/10502743

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The herpesvirus protease: mechanistic studies and discovery of inhibitors of the human cytomegalovirus protease

Autor: D L, Flynn, D P, Becker, V M, Dilworth, M K, Highkin, P J, Hippenmeyer, K A, Houseman, L M, Levine, M, Li, A E, Moormann, A, Rankin, M V, Toth, C I, Villamil, A J, Wittwer, B C, Holwerda

Publikováno v: Drug design and discovery. 15(1)

The herpesvirus protease is a recently identified enzyme which is essential for viral replication. It is found in all herpesviruses and offers a new molecular target for therapeutic intervention. Its genomic structure has recently been described and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99afaa01994c62de57d966d4fc6eb286
https://pubmed.ncbi.nlm.nih.gov/9332827

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SC-53606, a potent and selective antagonist of 5-hydroxytryptamine4 receptors in isolated rat esophageal tunica muscularis mucosae

Autor: D C, Yang, B, Goldstin, A E, Moormann, D L, Flynn, G W, Gullikson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(3)

(1-S,8-S)-N-[(hexahydro-1H-pyrrolizin-1-yl)methyl]-6-chloroimi+ ++- dazo[1,2-a]pyridine-8-carboxamide hydrochloride (SC-53606) acts as an antagonist of 5-hydroxytryptamine4 (5-HT4) receptor-mediated relaxation of carbachol-induced contractions in rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1e60e7527eefa27941eb685bf0ac732
https://pubmed.ncbi.nlm.nih.gov/8396633

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SC-49518 enhances gastric emptying of solid and liquid meals and stimulates gastrointestinal motility in dogs by a 5-hydroxytryptamine4 receptor mechanism

Autor: G W, Gullikson, M A, Virina, R F, Loeffler, D C, Yang, B, Goldstin, S X, Wang, C, Moummi, D L, Flynn, D L, Zabrowski

Publikováno v: The Journal of pharmacology and experimental therapeutics. 264(1)

SC-49518 (N-[exo-(hexahydro-1H-pyrrolizine-1-yl)methyl]-2-methoxy-4- amino-5-chlorobenzamide HCl), a new benzamide gastrointestinal prokinetic compound, was investigated to determine its ability to stimulate gastrointestinal motility in vivo and whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cb2a9a28789d850413a740dff843d5ee
https://pubmed.ncbi.nlm.nih.gov/8380862

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