EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner

Autor: A Rehfeld, D L Egeberg, K Almstrup, J H Petersen, S Dissing, N E Skakkebæk

Publikováno v: Endocrine Connections, Vol 7, Iss 1, Pp 16-25 (2017)

Human sperm cell function must be precisely regulated to achieve natural fertilization. Progesterone released by the cumulus cells surrounding the egg induces a Ca2+ influx into human sperm cells via the CatSper Ca2+-channel and thereby controls sper

Externí odkaz: https://doaj.org/article/29ed8fc8592d4ec7aeaba326106a5c48

Average sperm count remains unchanged despite reduction in maternal smoking:results from a large cross-sectional study with annual investigations over 21 years

Autor: Nina Mørup, Loa Nordkap, Stine A. Holmboe, Anders Juul, Niels E. Skakkebæk, Sofia B. Winge, M. Blomberg Jensen, Marianna Krause, Ulla Nordström Joensen, Lærke Priskorn, Katharina M. Main, Niels Jørgensen, Anne Kirstine Bang, Tina Kold Jensen, D. L. Egeberg Palme, Elisabeth Carlsen

Publikováno v: Priskorn, L, Nordkap, L, Bang, A K, Krause, M, Holmboe, S A, Egeberg Palme, D L, Winge, S B, Mørup, N, Carlsen, E, Joensen, U N, Blomberg Jensen, M, Main, K M, Juul, A, Skakkebaek, N E, Jensen, T K & Jørgensen, N 2018, ' Average sperm count remains unchanged despite reduction in maternal smoking : results from a large cross-sectional study with annual investigations over 21 years ', Human Reproduction, vol. 33, no. 6, pp. 998-1008 . https://doi.org/10.1093/humrep/dey090

Study question How are temporal trends in lifestyle factors, including exposure to maternal smoking in utero, associated to semen quality in young men from the general population? Summary answer Exposure to maternal smoking was associated with lower

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e574be3fe3f7438ef64ab9afffff137
https://portal.findresearcher.sdu.dk/da/publications/401d98d6-03b9-4fb9-bdfe-7d9eb24c1cbd

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Expression of the vitamin D metabolizing enzyme CYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality

Autor: M, Blomberg Jensen, A, Jørgensen, J E, Nielsen, P J, Bjerrum, M, Skalkam, J H, Petersen, D L, Egeberg, S, Bangsbøll, A N, Andersen, N E, Skakkebaek, A, Juul, E, Rajpert-De Meyts, S, Dissing, H, Leffers, N, Jørgensen

Publikováno v: International journal of andrology. 35(4)

Vitamin D (VD) is important for male reproduction in mammals and the VD receptor (VDR) and VD-metabolizing enzymes are expressed in human spermatozoa. The VD-inactivating enzyme CYP24A1 titrates the cellular responsiveness to VD, is transcriptionally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdfdd8f046c0e92d3986558dea350a80
https://pubmed.ncbi.nlm.nih.gov/22404291