Zobrazeno 1 - 10
of 23
pro vyhledávání: '"D L DeCamp"'
Autor:
W. J. Howe, W. T. Lowther, J. O. Hui, W. G. Tarpley, D. E. Emmert, Chetana Rao, A G Tomasselli, John H. Kinner, V. S. Bradford, D. L. Alexander, Tomi K. Sawyer, B.M. Dunna, Robert A. Conradi, D. L. Decamp, Clark W. Smith, Allen W. Harrison, Charles S. Craik, James Michael Tustin, T. J. Mcquade, Robert L. Heinrikson, Y. Z. Zhang, Philip S. Burton, Jed F. Fisher, Roger A. Poorman, Joseph B. Moon, Jackson B. Hester, D J Staples, L. Liu, P. E. Scarborough, Maggiora Linda Louise
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:819-824
The structure-activity relationships and pharmacophore modeling aspects of a series of HIV PR inhibitors modified at the N- and/or C-terminus of the dipeptide isostere ChaΨ[CH(OH)CH2]Val (Cha, cyclohexylalanine) are reported. The HIV PR binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b57d250dd9d5791ff9b0e19fb8eaad6
https://doi.org/10.1016/s0960-894x(00)80673-3
https://doi.org/10.1016/s0960-894x(00)80673-3
Autor:
Zhihua Sui, Paul R. Ortiz de Montellano, James J. De Voss, D. L. Decamp, Charles S. Craik, Jia Li
Publikováno v:
Synthesis. 1993:803-808
Haloperidol ketals and ethanedithioketals of interest as HIV-1 protease inhibitors were synthesized by addition of organolithium and organomagnesium reagents to ketone precursors already containing the ketal or thioketal functionality. Addition of Gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2c23fcb35deb7dc74e946000f31260
https://doi.org/10.1055/s-1993-25946
https://doi.org/10.1055/s-1993-25946
Autor:
Myoung Seo Koo, D. L. Decamp, Rafael Salto, Jeanne L. Lucich, Stephen B. Kahl, Lilia M. Babé, Charles S. Craik
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c894861c013ef611b372e6f2c4d12e3
https://doi.org/10.1002/chin.199302219
https://doi.org/10.1002/chin.199302219
Autor:
L. Liu, Alexander Wlodawer, Tomi K. Sawyer, D. L. Decamp, Robert L. Heinrikson, K. O'connell, Ben M. Dunn, Joseph B. Moon, Jackson B. Hester, D J Staples, Mariusz Jaskolski, Jennifer L. Harris, Roger A. Poorman, Heinrich J. Schostarez, Clark W. Smith, A G Tomasselli, J. O. Hui, Charles S. Craik, W. J. Howe, W. T. Lowther
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d23a689ed0032396aa16b956d37ebfc
https://doi.org/10.1002/chin.199307301
https://doi.org/10.1002/chin.199307301
Autor:
W. J. Howe, W. T. Lowther, A G Tomasselli, D. E. Emmert, D J Staples, Jackson B. Hester, W. G. Tarpley, J. O. Hui, Ben M. Dunn, John H. Kinner, Robert L. Heinrikson, Y. Z. Zhang, Tomi K. Sawyer, Charles S. Craik, D. L. Decamp, James Michael Tustin, T. J. Mcquade, D. L. Alexander, Allen W. Harrison, P. E. Scarborough, Robert A. Conradi, Jed F. Fisher, Roger A. Poorman, Philip S. Burton, Maggiora Linda Louise, V. S. Bradford, Joseph B. Moon, L. Liu, Clark W. Smith, Chetana Rao
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b99dbead49d3038ea527912ab65dad7
https://doi.org/10.1002/chin.199509217
https://doi.org/10.1002/chin.199509217
Publikováno v:
Journal of Biological Chemistry. 265:13890-13898
A synthetic DNA fragment encoding a protease precursor of the human immunodeficiency virus type 2 (HIV2) was cloned and expressed in bacteria and yeast. A recombinant plasmid encoding a hybrid polypeptide consisting of human superoxide dismutase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07ebce7614d3effaac2bfa88fe45f164
https://doi.org/10.1016/s0021-9258(18)77432-2
https://doi.org/10.1016/s0021-9258(18)77432-2
Autor:
W. J. Howe, Robert L. Heinrikson, Carol A. Bannow, J. O. Hui, A G Tomasselli, D L DeCamp, I M Reardon, C S Craik, D J Staples, Tomi K. Sawyer
Publikováno v:
Journal of Biological Chemistry. 265:14675-14683
Highly purified, recombinant preparations of the virally encoded proteases from human immunodeficiency viruses (HIV) 1 and 2 have been compared relative to 1) their specificities toward non-viral protein and synthetic peptide substrates, and 2) their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa638659f7a59d753b524a0b8f2aa9a
https://doi.org/10.1016/s0021-9258(18)77355-9
https://doi.org/10.1016/s0021-9258(18)77355-9
Receptor-recognized forms of alpha 2-macroglobulin (alpha 2M*) bind to two macrophage receptors: an endocytic receptor, the low density lipoprotein receptor-related protein/alpha 2M receptor (LRP/alpha 2MR), and a G protein-coupled receptor, the alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf7d017e3bf8514c64a6d26f94ced5
https://europepmc.org/articles/PMC507171/
https://europepmc.org/articles/PMC507171/
Autor:
Lilia M. Babé, Paul R. Ortiz de Montellano, James J. De Voss, Charles S. Craik, Rafael Salto, D. L. Decamp, Zhihua Sui
Publikováno v:
Journal of medicinal chemistry. 37(5)
The proteases expressed by the HIV-1 and HIV-2 viruses process the polyproteins encoded by the viral genomes into the mature proteins required for virion replication and assembly. Eight analogs of haloperidol have been synthesized that cause time-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbaad798144f69e0f9d5f7eb612e216
https://pubmed.ncbi.nlm.nih.gov/8126707
https://pubmed.ncbi.nlm.nih.gov/8126707
Autor:
E, Rutenber, E B, Fauman, R J, Keenan, S, Fong, P S, Furth, P R, Ortiz de Montellano, E, Meng, I D, Kuntz, D L, DeCamp, R, Salto
Publikováno v:
The Journal of biological chemistry. 268(21)
A stable, non-peptide inhibitor of the protease from type 1 human immunodeficiency virus has been developed, and the stereochemistry of binding defined through crystallographic three-dimensional structure determination. The initial compound, haloperi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea2299a8fe6219018a260bdeac813dc5
https://pubmed.ncbi.nlm.nih.gov/8340363
https://pubmed.ncbi.nlm.nih.gov/8340363