Zobrazeno 1 - 10 of 15 pro vyhledávání: '"D L, Weiner"'
2
A forecasting approach to accelerate drug development
Autor: C A, Hunt, S, Guzy, D L, Weiner
Publikováno v: Statistics in medicine. 17(15-16)
The clinical phase of drug development should be concluded sooner and at a lower cost if primarily only the pivotal and supportive studies were to be conducted. Such improved efficiency requires development of a decision support system that delivers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7f55fa241cd3791387339dd9fc37ed3
https://pubmed.ncbi.nlm.nih.gov/9749443
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3
Characterization of tumor-infiltrating lymphocytes from murine mammary adenocarcinomas
Autor: I H, Ames, G M, Gagne, D L, Weiner, D G, Tice
Publikováno v: Anticancer research. 14(3A)
The aim of this investigation was to assess the in vitro functional and phenotypic characteristics of lymphocytes isolated from C3H mouse mammary adenocarcinomas. A protocol was developed for the expansion of TILs in long-term culture. The homing pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::11e2e98b447b343f1bfb638da51b1b32
https://pubmed.ncbi.nlm.nih.gov/8074488
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4
A systematic approach to identifying and modeling the source of pharmacokinetic (PK) non-linearity
Autor: Carl C. Peck, Dong-Seok Yim, D. L. Weiner, Howard Lee, N. S. Berry
Publikováno v: Clinical Pharmacology & Therapeutics. 75:P90
Purpose To develop a systematic approach to identify and model the source of nonlinearity, detected as non-constant AUC/dose and Cmax/dose ratios, observed in PK analyses of ascending dose exposures (6–100 mg) of talampanel, an innovative antiepile
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::103b4dd469101215b32d74fb5d87121b
https://doi.org/10.1016/j.clpt.2003.11.346
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8
Bioavailability of terfenadine in man
Autor: Mary Myers, GJ Wright, T. D. Dusebout, Clarence Cook, M. J. Cawein, S. A. Biedenbach, Richard A. Okerholm, GA Leeson, Valerie Schindler, B. J. Walker, R. H. Hook, D. L. Weiner
Publikováno v: Biopharmaceutics & Drug Disposition. 2:185-190
Fourteen normal male subjects were given either 60mg or 180mg of terfenadine suspension in a randomized two-way crossover study. Peak plasma concentrations of 1.544 +/- 0.726 (mean +/- S.D.) ng ml-1 were obtained in 0.786 h following the 60 mg dose a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377e3cd825dc20afa8622d7f87fef831
https://doi.org/10.1002/bdd.2510020211
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9
NONLIN84/PCNONLIN: software for the statistical analysis of nonlinear models
Autor: D L, Weiner
Publikováno v: Methods and findings in experimental and clinical pharmacology. 8(10)
A new software package, NONLIN84, has been developed for the analysis of general nonlinear models including pharmacokinetic models. NONLIN84 is easier to use than the older NONLIN77, and can handle a wider class of estimation problems, such as maximu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ed0f77c0d98af7e769b8de589e7bc6e
https://pubmed.ncbi.nlm.nih.gov/3784700
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