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Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to a truncated topoisomerase II alpha messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone

Autor: W G, Harker, D L, Slade, R L, Parr, M H, Holguin

Publikováno v: Cancer research. 55(21)

Topoisomerase II alpha is an essential nuclear enzyme involved in DNA replication and a target for many of the clinically useful antineoplastic agents. In a mitoxantrone-selected human leukemia cell line, HL-60/MX2, cellular topoisomerase II (topo II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b93c93634e45f55599cfdb829e4d23aa
https://pubmed.ncbi.nlm.nih.gov/7585537

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Alterations in the topoisomerase II alpha gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II beta enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line

Autor: W G, Harker, D L, Slade, R L, Parr, P W, Feldhoff, D M, Sullivan, M H, Holguin

Publikováno v: Cancer research. 55(8)

A human HL-60 leukemia cell line selected for resistance to mitoxantrone, HL-60/MX2, displays cross-resistance only to agents whose cytotoxicities result from interaction with the nuclear enzyme DNA topoisomerase II (topo II). The topo II catalytic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04bf5fb7900d094537df0cbf280a3165
https://pubmed.ncbi.nlm.nih.gov/7712479

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Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin

Autor: R, Kapoor, D L, Slade, A, Fujimori, Y, Pommier, W G, Harker

Publikováno v: Oncology research. 7(2)

Two camptothecin-resistant variants of the CEM human leukemia cell line were developed by stepwise selection in camptothecin (CPT) in vitro. The two lines, named CEM/C1 and CEM/C2, were found to be approximately 31- and 970-fold less sensitive to CPT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9aace4eee1d47b641da6818d82c5ba7f
https://pubmed.ncbi.nlm.nih.gov/7579731

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Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II beta isoform

Autor: W G Harker, Drake Fh, R L Parr, D L Slade

Publikováno v: Biochemistry. 30(41)

Mitoxantrone-resistant variants of the human HL-60 leukemia cell line are cross-resistant to several natural product and synthetic antineoplastic agents. The resistant cells (HL-60/MX2) retain sensitivity to the Vinca alkaloids vincristine and vinbla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be4608077e913671f225d74bc424de1
https://pubmed.ncbi.nlm.nih.gov/1655025

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Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression

Autor: W G, Harker, D L, Slade, W S, Dalton, P S, Meltzer, J M, Trent

Publikováno v: Cancer research. 49(16)

A multidrug-resistant variant of the human HL-60 promyelocytic leukemia cell line (HL-60/MX2) has been isolated in vitro by subculturing these cells in progressively increasing concentrations of mitoxantrone. The MX2 cells are cross-resistant to etop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70ccbdbc2e66086494b4d83979602fac
https://pubmed.ncbi.nlm.nih.gov/2568172

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