Výsledky vyhledávání - "D L, Redmond"

Parasite vaccines – recent progress and problems associated with their development

Autor: D. L. Redmond, D. P. Knox

Publikováno v: Parasitology. 133:S1-S8

The treatment and prevention of parasitism in both humans and livestock continues to rely almost exclusively on the use of antiparasitic drugs – an approach which has limitations, particularly as reinfection, which occurs rapidly in endemic regions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c07edf817d41064a34cbbcaa4acdaff
https://doi.org/10.1017/s0031182006001776

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Further protection studies using recombinant forms of Haemonchus contortus cysteine proteinases

Autor: D. L. Redmond, D. P. Knox

Publikováno v: Parasite Immunology. 28:213-219

Significant levels of protection against Haemonchus contortus have been achieved in sheep by vaccination with a cysteine proteinase-enriched fraction (TSBP) isolated from the gut of adult parasites. Protection is associated with three cathepsin B-lik

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11083f426baf0f5baa4e99b29ebaa7f
https://doi.org/10.1111/j.1365-3024.2006.00823.x

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Characterization of proteinases in different isolates of adult Haemonchus contortus

Autor: R. Windham, D. L. Redmond

Publikováno v: Parasitology. 130:429-435

A high degree of intra- and inter-geographical variation has been demonstrated previously in the excretory/secretory proteinases released by adult Haemonchus contortus. Proteinase activity has also been associated with host-protective ‘hidden’ an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6127ec59cb8413d71d34a31af039b9a4
https://doi.org/10.1017/s0031182004006687

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Further immunization and biochemical studies with a protective antigen complex from the microvillar membrane of the intestine of Haemonchus contortus

Autor: S K, Smith, D, Pettit, G F, Newlands, D L, Redmond, P J, Skuce, D P, Knox, W D, Smith

Publikováno v: Parasite Immunology. 21:187-199

Immunization of sheep with a protective antigen complex from the intestinal cells of Haemonchus contortus in Freund's adjuvant stimulated individually variable antibody responses but still conferred significant protection against parasite infection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7b3ae315d21acd86903632e07fbb823
https://doi.org/10.1046/j.1365-3024.1999.00217.x

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Characterization of proteinases in extracts of adultHaemonchus contortus, the ovine abomasal nematode

Autor: D. L. Redmond, D. P. Knox, D. G. Jones

Publikováno v: Parasitology. 106:395-404

SUMMARYThe degradation of several protein substrates, including the blood proteins haemoglobin, albumin and fibrinogen, by proteinases present in extracts of adultHaemonchus contortuswas examined over a broad pH range. These proteinases were further

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a107ff20248225086ba33a0092e1a471
https://doi.org/10.1017/s0031182000067147

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Molecular cloning and characterisation of a putative aspartate proteinase associated with a gut membrane protein complex from adult Haemonchus contortus

Autor: D, Longbottom, D L, Redmond, M, Russell, S, Liddell, W D, Smith, D P, Knox

Publikováno v: Molecular and biochemical parasitology. 88(1-2)

A cDNA was isolated from an adult Haemonchus contortus cDNA expression library the deduced amino acid sequence of which showed significant homology to mammalian pepsinogen sequences. The library was screened with antisera raised against Haemonchus ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::188f4ab5adaaf2714febfe452efb26cc
https://pubmed.ncbi.nlm.nih.gov/9274868

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Molecular cloning and characterisation of a developmentally regulated putative metallopeptidase present in a host protective extract of Haemonchus contortus

Autor: D L, Redmond, D P, Knox, G, Newlands, W D, Smith

Publikováno v: Molecular and biochemical parasitology. 85(1)

Antisera from lambs immunised with the Haemonchus contortus integral membrane protein complex, Haemonchus galactose-containing glycoprotein (H-gal-GP), the lambs being refractory to subsequent challenge, were used to identify several clones from an a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdb9cf88eac90fe23d7c9e215ca8b373
https://pubmed.ncbi.nlm.nih.gov/9108550

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