Výsledky vyhledávání

Preparation of Recombinant RNase Single-Chain Antibody Fusion Proteins

Autor: D L, Newton, S M, Rybak

Publikováno v: Methods in molecular medicine. 25

Selective cytotoxicity is an important goal of specific drug targeting. Toward this end, toxins isolated primarily from higher plants and bacteria have been coupled to monoclonal antibodies (MAbs) and evaluated for their clinical efficacy in cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fde684c99714cc388e76405398bd76df
https://pubmed.ncbi.nlm.nih.gov/21318842

Zobrazit plný text záznamu

Construction of ribonuclease-antibody conjugates for selective cytotoxicity

Autor: D L, Newton, S M, Rybak

Publikováno v: Methods in molecular medicine. 25

Immunotoxins based on human and humanized ribonuclease may have potential for cancer therapy while exhibiting less toxic side effects and stimulating less of an immune response in humans than immunotoxins based on plant and bacterial toxins (1). Both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29b2b4be0d57c882352088b8326cc9a9
https://pubmed.ncbi.nlm.nih.gov/21318838

Zobrazit plný text záznamu

Preparation and preclinical characterization of RNase-based immunofusion proteins

Autor: D L, Newton, S M, Rybak

Publikováno v: Methods in molecular biology (Clifton, N.J.). 160

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8a75f8b039274fbda6db84f18409a6a
https://pubmed.ncbi.nlm.nih.gov/11265299

Zobrazit plný text záznamu

Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis

Autor: M S, Iordanov, O P, Ryabinina, J, Wong, T H, Dinh, D L, Newton, S M, Rybak, B E, Magun

Publikováno v: Cancer research. 60(7)

Cytotoxic endoribonucleases (RNases) possess a potential for use in cancer therapy. However, the molecular determinants of RNase-induced cell death are not well understood. In this work, we identify such determinants of the cytotoxicity induced by on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12ee7657dfd5d543a632319729db7dfa
https://pubmed.ncbi.nlm.nih.gov/10766189

Zobrazit plný text záznamu

Establishing guidance for the handling and containment of new chemical entities and chemical intermediates in the pharmaceutical industry

Autor: M J, Olson, S P, Binks, D L, Newton, G C, Clark

Publikováno v: Occupational medicine (Philadelphia, Pa.). 12(1)

This information is intended to guide scientists and technicians working with pharmaceutical substances early in development, before occupational exposure levels (OELs) can be set. The focus is on determining hazard categories, or occupational exposu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::353fb033dd25d9240992f7c72e84ff30
https://pubmed.ncbi.nlm.nih.gov/9153052

Zobrazit plný text záznamu

Expression and characterization of recombinant human eosinophil-derived neurotoxin and eosinophil-derived neurotoxin-anti-transferrin receptor sFv

Autor: D L, Newton, P J, Nicholls, S M, Rybak, R J, Youle

Publikováno v: The Journal of biological chemistry. 269(43)

The gene for the human recombinant eosinophil-derived neurotoxin (rEDN) was synthesized and fused to the gene encoding a single chain antibody (sFv) to the human transferrin receptor (EDNsFv). Both rEDN and EDNsFv were expressed as insoluble proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec6eec36edcf8ad353178bd98bb41534
https://pubmed.ncbi.nlm.nih.gov/7929408

Zobrazit plný text záznamu

Humanized immunotoxins

Autor: M, Gadina, D L, Newton, S M, Rybak, Y N, Wu, R J, Youle

Publikováno v: Therapeutic immunology. 1(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0991fd29d854c0957acca7cb86c16d6
https://pubmed.ncbi.nlm.nih.gov/7584480

Zobrazit plný text záznamu

Cytotoxic ribonuclease chimeras. Targeted tumoricidal activity in vitro and in vivo

Autor: D L, Newton, O, Ilercil, D W, Laske, E, Oldfield, S M, Rybak, R J, Youle

Publikováno v: The Journal of biological chemistry. 267(27)

Monoclonal antibodies to the transferrin receptor or to the T cell antigen, CD5, were chemically linked to mammalian RNase A and found to specifically inhibit protein synthesis in antigen-positive cells. Antibody-mediated specificity of these cytotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58a96923917f7100ea64860ba8077831
https://pubmed.ncbi.nlm.nih.gov/1527074

Zobrazit plný text záznamu

Cell surface and intracellular functions for ricin galactose binding

Autor: D L, Newton, R, Wales, P T, Richardson, S, Walbridge, S K, Saxena, E J, Ackerman, L M, Roberts, J M, Lord, R J, Youle

Publikováno v: The Journal of biological chemistry. 267(17)

The role of the two galactose binding sites of ricin B chain in ricin toxicity was evaluated by studying a series of ricin point mutants. Wild-type (WT) ricin and three ricin B chain point mutants having mutations in either 1) the first galactose bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3cb187d3515a8952b85bde9628cc4698
https://pubmed.ncbi.nlm.nih.gov/1601861

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání