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dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo

Autor: R E Park, K Yazdanbakhsh, M Levine, Y T Ip, D Kosman

Publikováno v: Genes & Development. 6:1518-1530

The first step in the differentiation of the Drosophila mesoderm is the activation of two regulatory genes, twist (twi) and snail (sna), in ventral regions of early embryos. sna is a transcriptional repressor that is uniformly expressed throughout th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99c1ce9e3eaaef94fb3547727ee2c0e
https://doi.org/10.1101/gad.6.8.1518

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The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos

Autor: Y. T. Ip, Jin Jiang, Michael Levine, D. Kosman

Publikováno v: Genes & Development. 5:1881-1891

A gradient of the maternal morphogen dorsal (dl) initiates the differentiation of various tissues along the dorsal-ventral axis of early Drosophila embryos. dl is a sequence-specific DNA-binding protein that is related to the mammalian regulatory fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ce1f8259f41c8deadb9863afee9122
https://doi.org/10.1101/gad.5.10.1881

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Spatio-temporal registration of the expression patterns of Drosophila segmentation genes

Autor: E M, Myasnikova, D, Kosman, J, Reinitz, M G, Samsonova

Publikováno v: Proceedings. International Conference on Intelligent Systems for Molecular Biology.

The application of image registration techniques resulted in the construction of an integrated atlas of Drosophila segmentation gene expression in both space and time. The registration method was based on a quadratic spline approximation with flexibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c847d0c6654239b4a34ebd4cb1b40568
https://pubmed.ncbi.nlm.nih.gov/10786302

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Stripe forming architecture of the gap gene system

Autor: J, Reinitz, D, Kosman, C E, Vanario-Alonso, D H, Sharp

Publikováno v: Developmental genetics. 23(1)

In this report, we show that gap genes encode exactly one set of pair-rule stripes, which occur in the native even-skipped position. The core of this work is a detailed analysis that shows how this conclusion follows from the arrangement of gap domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a709f54f6a51ebd8f074f41927b61e35
https://pubmed.ncbi.nlm.nih.gov/9706690

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Automated assay of gene expression at cellular resolution

Autor: D, Kosman, J, Reinitz, D H, Sharp

Publikováno v: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.

We have recently developed an automated image processing method for obtaining quantitative values for average levels of gene expression at the resolution of a single cell. This method is described in the present paper. We place this method within a l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34637d047226e3b6703389a54a222549
https://pubmed.ncbi.nlm.nih.gov/9697167

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