PlzR regulates type IV pili assembly in Pseudomonas aeruginosa via PilZ binding

Autor: Hanne Hendrix, Annabel Itterbeek, Hannelore Longin, Lize Delanghe, Eveline Vriens, Marta Vallino, Eveline-Marie Lammens, Farhana Haque, Ahmed Yusuf, Jean-Paul Noben, Maarten Boon, Matthias D. Koch, Vera van Noort, Rob Lavigne

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Type IV pili (T4P) are thin, flexible filaments exposed on the cell surface of gram-negative bacteria and are involved in pathogenesis-related processes, including cell adsorption, biofilm formation, and twitching motility. Bacteriophages of

Externí odkaz: https://doaj.org/article/71ed362eb03f4fa1880aa96c61c04493

An evaluation of the outcomes associated with peritoneal catheter use in neonates undergoing cardiac surgery: A multicenter studyCentral MessagePerspective

Autor: David M. Kwiatkowski, MD, MS, Jeffrey A. Alten, MD, Kenneth E. Mah, MD, David T. Selewski, MD, Tia T. Raymond, MD, MBA, Natasha S. Afonso, MD, MPH, Joshua J. Blinder, MD, Matthew T. Coghill, MD, David S. Cooper, MD, MPH, Joshua D. Koch, MD, Catherine D. Krawczeski, MD, David L.S. Morales, MD, Tara M. Neumayr, MD, A.K.M. Fazlur Rahman, PhD, Garrett Reichle, MS, Sarah Tabbutt, MD, PhD, Tennille N. Webb, MD, Santiago Borasino, MD, Huaiyu Zang, David Winlaw, MD, David Bailly, DO, Stuart Goldstein, MD, Katja Gist, DO, Katie L. Brandewie, MD, Priya N. Bhat, MD, John W. Diddle, MD, Muhammad Ghbeis, MD, Parthak Prodhan, MD, Xiomara Garcia, MD, Shannon Ramer, Mindy Albertson, Zahidee Rodriquez, MD, Mary Lukacs, Michael Gaies, MD, Joshua Freytag, Amanda Sammons, Hideat Abraha, John Butcher, Dominic Zanaboni, MD, Joan Sanchez de Toledo, MD, PhD, Yuliya A. Domnina, MD, Lucas Saenz, MD, Tracy Baust, Jane Kluck, RN, Jun Sasaki, MD, Aanish Raees, MD, Erika R. O'Neil, MD, Javier J. Lasa, MD, Patrick A. Phillips, Kristal M. Hock, Kevin Valentine, MD, Sachin Tadphale, MBBS, Jason R. Buckley, MD, Luke Schroeder, MD, Shanelle Clarke, MD, Wenying Zhang, MD, Andrew Smith, MD, Mohammed Absi, MD, David J. Askenazi, MD, David J. Askenazi, Parthak Prodhan, Xiomara Garcia, Shanelle Clarke, Zahidee Rodriquez, Muhammad Ghbeis, Jun Sasaki, Katie L. Brandewie, Katja Gist, Michael Gaies, Aanish Raees, Dominic Zanaboni, Joan Sanchez de Toledo, Yuliya A. Domnina, Lucas Saenz, John W. Diddle, Jane Kluck, Linda Duncan, Rebecca A. Bertrandt, Lisa J. Sosa, Priya N. Bhat, Erika R. O’Neal, Javier J. Lasa, Kevin Valentine, Jason R. Buckley, Luke Schroeder, Tammy Doman, Suzanne Viers, Wenying Zhang, Andrew H. Smith, Sachin Tadphale, Mohammed Absi, David K. Bailly

Publikováno v: JTCVS Open, Vol 19, Iss , Pp 275-295 (2024)

Objective: The study objective was to determine if intraoperative peritoneal catheter placement is associated with improved outcomes in neonates undergoing high-risk cardiac surgery with cardiopulmonary bypass. Methods: This propensity score–matche

Externí odkaz: https://doaj.org/article/275d57c839a44569916f9a9aa97ba836

Viral aetiology of acute respiratory illnesses in patients with a suspicion of severe acute respiratory syndrome (SARS) in Switzerland

Autor: C Deffernez, Y Thomas, D Koch, VM Spicher, I Uckay, D Schultze, G Siegl, HC Matter

Publikováno v: Swiss Medical Weekly, Vol 133, Iss 2728 (2003)

Externí odkaz: https://doaj.org/article/ab2bb94949b64feb9020fa0851e5cd5f

The phage-encoded PIT4 protein affects multiple two-component systems of Pseudomonas aeruginosa

Autor: Kaat Schroven, Leena Putzeys, Alison Kerremans, Pieter-Jan Ceyssens, Marta Vallino, Jan Paeshuyse, Farhana Haque, Ahmed Yusuf, Matthias D. Koch, Rob Lavigne

Publikováno v: Microbiology Spectrum, Vol 11, Iss 6 (2023)

ABSTRACT Two-component systems (TCSs) control a large proportion of virulence factors in Pseudomonas aeruginosa. Yet, investigations on inhibitors of regulatory pathways of TCSs remain scarce, despite their potential in anti-virulence strategies. Thi

Externí odkaz: https://doaj.org/article/4e46018187c744cc919d7c005e5d76b6

Bridging the gap: The critical role of laboratory developed tests in clinical toxicology

Autor: Jaime H. Noguez, Christopher D. Koch

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 28, Iss , Pp 70-74 (2023)

Externí odkaz: https://doaj.org/article/93f4c64edcb7418c843b834c7914f9a7