Zobrazeno 1 - 10
of 184
pro vyhledávání: '"D Kirn"'
Autor:
G O, Reynolds, L, Manning, D, Kirn, H, Klein, O, Hampton, O, Burke, R, Buckley, D, Rentz, R, Sperling, G A, Marshall, R E, Amariglio
Publikováno v:
The Journal Of Prevention of Alzheimer's Disease.
With the increasing focus on prevention of Alzheimer's disease, there is need for characterization of preclinical populations. Local participant registries offer an opportunity to facilitate research engagement via remote data collection, inform recr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4788e11f644a184379c9b992abb81658
https://doi.org/10.14283/jpad.2022.31
https://doi.org/10.14283/jpad.2022.31
Autor:
Kotterman M, D Kirn, Holt J, Christopher A. Schmitt, P Szymanski, M Quezada, T Vazin, Roxanne H. Croze, Hassanipour M, G. Beliakoff, K. Barglow, David V. Schaffer, Francis P, Leong M
Targeted AAV vectors are needed for safe and efficient delivery to and transduction of specific tissue target(s) in patients. Effective intravitreal delivery for retina gene therapy is not feasible with wildtype AAV. We employed directed evolution in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d856b18df0a4914bced918e54fd9d6
https://doi.org/10.1101/2021.06.24.449775
https://doi.org/10.1101/2021.06.24.449775
Autor:
K. Whittlesey, G. Brooks, P. Szymanski, G. Beliakoff, J. Nye, R. Croze, C. Schmitt, J. Bickta, K. Barglow, M. Kotterman, P. Francis, D. Schaffer, D. Kirn
Publikováno v:
TP83. TP083 HEY JUDE - NOVEL FINDINGS FROM OMIC AND BIOINFORMATIC APPROACHES IN PULMONARY HYPERTENSION.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cbcf9aed590acba22f00edc8c3c360e
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3624
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3624
Autor:
Roxanne H. Croze, J. Nye, P Szymanski, Francis P, K. Whittlesey, Hassanipour M, L Johnson, G. Beliakoff, T Vazin, D Schaffer, Kotterman M, Christopher A. Schmitt, G Brooks, M Quezada, D Kirn
Publikováno v:
European Heart Journal. 40
Background Cardiac-targeted gene therapy vectors are needed. Fabry disease is a rare, X-linked disorder caused by mutations in the GLA gene, which encodes α-galactosidase A (GLA). Storage and accumulation of glycolipid substrates of GLA leads to org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f73bb121e32ebb88580811a8be2184d8
https://doi.org/10.1093/eurheartj/ehz748.0278
https://doi.org/10.1093/eurheartj/ehz748.0278
Akademický článek
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Autor:
D, Kirn
Publikováno v:
Ernst Schering Research Foundation workshop. (43)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7dc0597e618fbafe9f5d79d3e18c04fa
https://pubmed.ncbi.nlm.nih.gov/12894453
https://pubmed.ncbi.nlm.nih.gov/12894453
Autor:
T, Petit, K K, Davidson, C, Cerna, R A, Lawrence, D D, Von Hoff, C, Heise, D, Kirn, E, Izbicka
Publikováno v:
Anti-cancer drugs. 13(1)
The ONYX-015 virus is a mutated adenovirus that in theory selectively replicates and induces cytolysis in tumor cells lacking functional p53. The present study investigated whether ONYX-015 viral infection alone or in combination with conventional ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b2bc1fe8e2152f9c79f28e75b04a3fc
https://pubmed.ncbi.nlm.nih.gov/11914640
https://pubmed.ncbi.nlm.nih.gov/11914640
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(12)
Replication-selective adenoviruses are being developed as novel anticancer therapeutics. Clinical trials with dl 1520, an E1B-Mr 55,000 gene-deleted adenovirus (ONYX-015), have demonstrated selective viral replication and biological activity in head
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5872175583f95e955cf34d2a7435c075
https://pubmed.ncbi.nlm.nih.gov/11156251
https://pubmed.ncbi.nlm.nih.gov/11156251
Autor:
J, Nemunaitis, I, Ganly, F, Khuri, J, Arseneau, J, Kuhn, T, McCarty, S, Landers, P, Maples, L, Romel, B, Randlev, T, Reid, S, Kaye, D, Kirn
Publikováno v:
Cancer research. 60(22)
ONYX-015 is an E1B-55kDa gene-deleted adenovirus engineered to selectively replicate in and lyse p53-deficient cancer cells. To evaluate the selectivity of ONYX-015 replication and cytopathic effects for the first time in humans, we carried out a Pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36d9994cb99d57c7aa0762376efb4688
https://pubmed.ncbi.nlm.nih.gov/11103798
https://pubmed.ncbi.nlm.nih.gov/11103798
Autor:
I, Ganly, D, Kirn, G, Eckhardt, G I, Rodriguez, D S, Soutar, R, Otto, A G, Robertson, O, Park, M L, Gulley, C, Heise, D D, Von Hoff, S B, Kaye, S G, Eckhardt
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(3)
An E1B 55 kDa gene-deleted adenovirus, Onyx-015, which reportedly selectively replicates in and lyses p53-deficient cells, was administered by a single intratumoral injection to a total of 22 patients with recurrent head and neck cancer. The objectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88c11d1c13b848bafc5e308655bb60ad
https://pubmed.ncbi.nlm.nih.gov/10741699
https://pubmed.ncbi.nlm.nih.gov/10741699