Zobrazeno 1 - 10
of 827
pro vyhledávání: '"D Keefe"'
Autor:
Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P. Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S. Disch, Christopher J. Mulhern, Belinda L. Slakman, John W. Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D. Keefe, Peter J. Brown, Levon Halabelian, Rima Al-awar, Masoud Vedadi
Publikováno v:
Journal of Medicinal Chemistry. 66:5041-5060
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87d2380cfc1eda17d3f8edf2cae4eb67
https://doi.org/10.1021/acs.jmedchem.2c02132
https://doi.org/10.1021/acs.jmedchem.2c02132
Autor:
Matthew D Keefe, Haille E Soderholm, Hung-Yu Shih, Tamara J Stevenson, Kathryn A Glaittli, D Miranda Bowles, Erika Scholl, Samuel Colby, Samer Merchant, Edward W Hsu, Joshua L Bonkowsky
Publikováno v:
eLife, Vol 9 (2020)
Vanishing white matter disease (VWM) is a severe leukodystrophy of the central nervous system caused by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B). Current models only partially recapitulate key disease features, and
Externí odkaz:
https://doaj.org/article/0ee75c412d8f4dd58a470302d1887a1f
Autor:
D. Krasowska, T. Gambichler, C. Cortés, A. Horev, N. Compagno, S. S. Dahale, P. Papanastasiou, D. Keefe
Publikováno v:
Journal of the European Academy of Dermatology and Venereology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b34a8a812a7b6b13d6177036598c58d
https://doi.org/10.1111/jdv.19063
https://doi.org/10.1111/jdv.19063
Akademický článek
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Autor:
Denes Haase, John W. Cuozzo, John Barker, Pia Thommes, Michael Zahn, Avery Hunt, Vasileios Roumpelakis, Ying Zhang, Emily Trimby, Elise Gadouleau, Alain Dorali, Kostas Papadopoulos, Ole A. Andersen, Christoph E. Dumelin, Christel Compper, Michelle Southey, Christopher Lumley, Eric A. Sigel, Paolo A. Centrella, Barbara Mertins, Maisie Holbrow-Wilshaw, Spencer Napier, Adele Faulkner, Magali Dejob, Timothy Gorman, Alastair L Parkes, Boudewijn Dejonge, Thomas Krulle, Ricky Cain, Jennifer Williams, Boer Deng, Olivier Barbeau, Anthony D. Keefe, Sian Evans, David F. Corbett, Donnya Etheridge, Daniel B. Stein, Ryan M Dominic, Dawn M. Troast, Xianfu Li, Rajesh Odedra, Matthew A. Clark, Anthony P Dickie, Holly T Soutter, Kate Spear, Angelo Sanzone
Publikováno v:
Journal of Medicinal Chemistry. 64:14377-14425
This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas ae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::561a3ec469b1a8704e6a0431f9d286c1
https://doi.org/10.1021/acs.jmedchem.1c00888
https://doi.org/10.1021/acs.jmedchem.1c00888
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2541
Chemical ligation can be used to install encoding tags during the synthesis of DNA-encoded chemical libraries and can present a number of advantages. Here we describe methods to generate polymerase-readable oligonucleotide junctions and for the polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f058d4d17424a4c353653b0eab24f0c
https://pubmed.ncbi.nlm.nih.gov/36083539
https://pubmed.ncbi.nlm.nih.gov/36083539
Akademický článek
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Autor:
Joshua L. Bonkowsky, Spyridoula Tsetsou, Jerry A. Duran, L. Charles Murtaugh, Karla P. Figueroa, Kristi L. Russell, Mark B. Bromberg, Summer Gibson, Stefan M. Pulst, Matthew D. Keefe, Jonathan M. Downie, Lynn B. Jorde
Publikováno v:
Neurology. 97:e225-e235
ObjectiveTo identify novel disease associated loci for amyotrophic lateral sclerosis (ALS), we used sequencing data and performed in vitro and in vivo experiments to demonstrate pathogenicity of mutations identified inTP73.MethodsWe analyzed exome se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e965063455a60d78fd589eb5814976
https://doi.org/10.1212/wnl.0000000000012285
https://doi.org/10.1212/wnl.0000000000012285
Autor:
Shilpi Arora, Anna Kohlmann, Christopher D. Hupp, Julie Liu, Christelle Huguet, Allison Olszewski, Moritz von Rechenberg, John W. Cuozzo, Ying Zhang, Katy E Georgiadis, Matthew A. Clark, Esther C.Y. Lee, Charles J. Eyermann, Andrew J. McRiner, Paolo A. Centrella, Michael I Monteiro, Anthony D. Keefe, Benjamin Levin, Andrew D. Ferguson, Zooey Wang, Yanbin Liu
Publikováno v:
Journal of Medicinal Chemistry. 64:6730-6744
Inhibition of hydroxy acid oxidase 1 (HAO1) is a strategy to mitigate the accumulation of toxic oxalate that results from reduced activity of alanine-glyoxylate aminotransferase (AGXT) in primary hyperoxaluria 1 (PH1) patients. DNA-Encoded Chemical L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecd410b881fad4a6d7e1db049c6ba5c
https://doi.org/10.1021/acs.jmedchem.0c02271
https://doi.org/10.1021/acs.jmedchem.0c02271
Autor:
Peter D. Keefe
Publikováno v:
The European Physical Journal Special Topics. 230:993-1001
Macroscopic and mesoscopic-size Type I superconductors exhibit a first order phase transition in H–T space. For specimens undergoing an adiabatic phase transition, the latent heat is supplied or absorbed by the normal regime. This process, the magn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aa81bad99f96f0fe95ac32c56cd6d29
https://doi.org/10.1140/epjs/s11734-021-00099-9
https://doi.org/10.1140/epjs/s11734-021-00099-9