Zobrazeno 1 - 10
of 2 414
pro vyhledávání: '"D Kaiser"'
Autor:
Perry S. Choi, MD, Amit Sharir, BS, Yoshikazu Ono, MD, Masafumi Shibata, MD, Alexander D. Kaiser, PhD, Yellappa Palagani, PhD, Alison L. Marsden, PhD, Michael R. Ma, MD
Publikováno v:
JTCVS Open, Vol 22, Iss , Pp 395-404 (2024)
Objective: The study objective was to investigate the effect of free-edge length on valve performance in bicuspidization repair of congenitally diseased aortic valves. Methods: In addition to a constructed unicuspid aortic valve disease model, 3 repr
Externí odkaz:
https://doaj.org/article/c1be7404d01545efadb38b2f194354dd
Autor:
Desiree I. Frecot, Simone Blaess, Teresa R. Wagner, Philipp D. Kaiser, Bjoern Traenkle, Madeleine Fandrich, Meike Jakobi, Armin M. Scholz, Stefan Nueske, Nicole Schneiderhan-Marra, Cécile Gouttefangeas, Manfred Kneilling, Bernd J. Pichler, Dominik Sonanini, Ulrich Rothbauer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PurposeHuman OX40 (hOX40/CD134), a member of the TNF receptor superfamily, is mainly expressed on activated T lymphocytes. Triggered by its ligand OX40L (CD252), it provides costimulatory signals that support the differentiation, proliferation and lo
Externí odkaz:
https://doaj.org/article/ce3a8aa1d9c443469359f03d31106fa0
Autor:
M. Wallimann, K. Bouayed, E. Cannizzaro, D. Kaiser, A. Belot, E. Merlin, S. Poignant, C. Wouters, F. Hofer, T. Saurenmann, A. Koryllou, R. Carlomagno, M. Mejbri, M. Hofer, K. Theodoropoulou
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract Background Systemic juvenile idiopathic arthritis (systemic JIA) is a severe disease with both systemic and joint inflammation. This study aims to identify predictors of disease evolution within the systemic JIA population enrolled in the Ju
Externí odkaz:
https://doaj.org/article/a9f8b77a20714947b1c04c06e8fc2190
Autor:
Teresa R. Wagner, Simone Blaess, Inga B. Leske, Desiree I. Frecot, Marius Gramlich, Bjoern Traenkle, Philipp D. Kaiser, Dominik Seyfried, Sandra Maier, Amélie Rezza, Fabiane Sônego, Kader Thiam, Stefania Pezzana, Anne Zeck, Cécile Gouttefangeas, Armin M. Scholz, Stefan Nueske, Andreas Maurer, Manfred Kneilling, Bernd J. Pichler, Dominik Sonanini, Ulrich Rothbauer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Signal-regulatory protein α (SIRPα) expressed by myeloid cells is of particular interest for therapeutic strategies targeting the interaction between SIRPα and the “don’t eat me” ligand CD47 and as a marker to monitor macrophage infiltration
Externí odkaz:
https://doaj.org/article/29efe43cd84c4093b9130cdff8fcf447
Autor:
Daniel Junker, Alex Dulovic, Matthias Becker, Teresa R. Wagner, Philipp D. Kaiser, Bjoern Traenkle, Katharina Kienzle, Stefanie Bunk, Carlotta Struemper, Helene Haeberle, Kristina Schmauder, Natalia Ruetalo, Nisar Malek, Karina Althaus, Michael Koeppen, Ulrich Rothbauer, Juliane S. Walz, Michael Schindler, Michael Bitzer, Siri Göpel, Nicole Schneiderhan-Marra
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract As global vaccination campaigns against SARS-CoV-2 proceed, there is particular interest in the longevity of immune protection, especially with regard to increasingly infectious virus variants. Neutralizing antibodies (Nabs) targeting the re
Externí odkaz:
https://doaj.org/article/65541620e8964ed78cf2db87bc1b9e1e
Autor:
Alex Dulovic, Monika Strengert, Gema Morillas Ramos, Matthias Becker, Johanna Griesbaum, Daniel Junker, Karsten Lürken, Andrea Beigel, Eike Wrenger, Gerhard Lonnemann, Anne Cossmann, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Gérard Krause, Nicole Schneiderhan-Marra, Georg M.N. Behrens
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 4, Pp 743-750 (2022)
Patients undergoing chronic hemodialysis were among the first to receive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations because of their increased risk for severe coronavirus disease and high case-fatality rates. By using a
Externí odkaz:
https://doaj.org/article/bf1f2ba9a9164267856bf376d78e8a99
Autor:
Hanna Renk, Alex Dulovic, Alina Seidel, Matthias Becker, Dorit Fabricius, Maria Zernickel, Daniel Junker, Rüdiger Groß, Janis Müller, Alexander Hilger, Sebastian F. N. Bode, Linus Fritsch, Pauline Frieh, Anneke Haddad, Tessa Görne, Jonathan Remppis, Tina Ganzemueller, Andrea Dietz, Daniela Huzly, Hartmut Hengel, Klaus Kaier, Susanne Weber, Eva-Maria Jacobsen, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Maximilian Stich, Burkhard Tönshoff, Georg F. Hoffmann, Barbara Müller, Carolin Ludwig, Bernd Jahrsdörfer, Hubert Schrezenmeier, Andreas Peter, Sebastian Hörber, Thomas Iftner, Jan Münch, Thomas Stamminger, Hans-Jürgen Groß, Martin Wolkewitz, Corinna Engel, Weimin Liu, Marta Rizzi, Beatrice H. Hahn, Philipp Henneke, Axel R. Franz, Klaus-Michael Debatin, Nicole Schneiderhan-Marra, Ales Janda, Roland Elling
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
In this prospective cohort study, authors follow 328 households in Germany with at least one confirmed SARS-CoV-2 infection and find that children are more likely to seroconvert without symptoms and have higher specific antibody levels that persist l
Externí odkaz:
https://doaj.org/article/af0bd9036d2c4e6cb0fbd39a1d97ce6a
Autor:
Tatu Pantsar, Philipp D. Kaiser, Mark Kudolo, Michael Forster, Ulrich Rothbauer, Stefan A. Laufer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The molecular determinants of the residence time of a small molecule inhibitor at its target protein are not well understood. Here, Pantsar et al. show that the target protein’s conformational stability and solvent exposure are key factors governin
Externí odkaz:
https://doaj.org/article/ea56edd9054540ceba1fbe3572b2db6f
Autor:
Niels Werchau, Bettina Kotter, Elvira Criado-Moronati, Andre Gosselink, Nicole Cordes, Dominik Lock, Simon Lennartz, Carolin Kolbe, Nora Winter, Karin Teppert, Fabian Engert, Brian Webster, Joerg Mittelstaet, Daniel Schaefer, Peter Mallmann, Michael R. Mallmann, Dominik Ratiu, Mario Assenmacher, Thomas Schaser, Michael von Bergwelt-Baildon, Pierre Abramowski, Andrew D. Kaiser
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Solid tumors consist of malignant and nonmalignant cells that together create the local tumor microenvironment (TME). Additionally, the TME is characterized by the expression of numerous soluble factors such as TGF-β. TGF-β plays an important role
Externí odkaz:
https://doaj.org/article/c33c72814d7043f49b55860008ccb5cf
Autor:
Matthias Becker, Anne Cossmann, Karsten Lürken, Daniel Junker, Jens Gruber, Jennifer Juengling, Gema Morillas Ramos, Andrea Beigel, Eike Wrenger, Gerhard Lonnemann, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Gérard Krause, Nicole Schneiderhan-Marra, Monika Strengert, Alex Dulovic, Georg M. N. Behrens
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Haemodialysis patients respond poorly to vaccination and continue to be at-risk for severe COVID-19. Therefore, dialysis patients were among the first for which a fourth COVID-19 vaccination was recommended. However, targeted information on how to be
Externí odkaz:
https://doaj.org/article/c3c8a3ec127e47309ad52458e675fb17