Zobrazeno 1 - 10
of 38
pro vyhledávání: '"D K Spady"'
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 11, Pp 2289-2302 (1997)
These studies were undertaken to investigate the mechanism whereby diet modification alters the plasma concentration of high density lipoprotein (HDL) cholesteryl ester and apoA-I and to determine whether diet-induced alterations in circulating HDL l
Externí odkaz:
https://doaj.org/article/98d310403fd74efd9974b0c09effaddf
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 8, Pp 1598-1611 (1997)
These studies were done to determine whether an underlying metabolic difference could account for the higher concentration of cholesterol carried in low density lipoproteins (LDL-C) in male hyperresponder (HR) cynomolgus monkeys than in their hypores
Externí odkaz:
https://doaj.org/article/c582d3f1d7aa4629afa2c282881f105d
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 2, Pp 223-228 (1996)
Endotoxin (LPS) and cytokines increase cholesterol synthesis and the secretion of lipoproteins by the liver in rodents resulting in hypercholesterolemia. Cholesterol 7 alpha-hydroxylase (CAH) is the rate-limiting enzyme in the conversion of cholester
Externí odkaz:
https://doaj.org/article/1a9d3152e9554c59ae26558af0a7e6eb
Autor:
M Bertolotti, D K Spady
Publikováno v:
Journal of Lipid Research, Vol 37, Iss 8, Pp 1812-1822 (1996)
This study was performed to investigate the effects of 17 alpha-ethinyl estradiol, a potent hypocholesterolemic agent at pharmacological doses, on cholesterol balance in the liver and extrahepatic tissues of the rat in vivo. Female Sprague-Dawley rat
Externí odkaz:
https://doaj.org/article/0ac4cdc2500d4144af246a59a348b312
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 5, Pp 1009-1020 (1995)
These studies were undertaken to investigate the mechanisms involved in the regulation of hepatic low density lipoprotein (LDL) transport by n-3 fatty acids in the hamster and rat. Animals were fed n-3 or n-6 fatty acids with a cholesterol-free, very
Externí odkaz:
https://doaj.org/article/c865184896ae4f3d998a2885472760c4
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 1, Pp 67-79 (1995)
The suitability of the adult male cynomolgus monkey as a model for investigating genetic mechanisms that regulate dietary cholesterolemic response was evaluated by carrying out a systematic characterization of the major aspects of cholesterol metabol
Externí odkaz:
https://doaj.org/article/38416e8952314626a020a7b7a8904b4d
Autor:
D K Spady, J M Dietschy
Publikováno v:
Journal of Lipid Research, Vol 24, Iss 3, Pp 303-315 (1983)
This study was undertaken to measure and compare the rates at which digitonin-precipitable sterols (DPS) were synthesized in vivo in the major organs of five different animal species. These rates were assessed by measuring the velocity at which [3H]w
Externí odkaz:
https://doaj.org/article/cf90c6265b144115b48f35cdfd68ed2b
Publikováno v:
Journal of Lipid Research, Vol 26, Iss 4, Pp 465-472 (1985)
The relationship between rates of hepatic sterol synthesis and rates of hepatic low density lipoprotein (LDL) uptake (clearance) was studied in animals with high (rats), low (female hamsters), and very low (male hamsters) basal rates of hepatic stero
Externí odkaz:
https://doaj.org/article/233e78febd2a41a0984794f5d7efc138
Autor:
J M Dietschy, D K Spady
Publikováno v:
Journal of Lipid Research, Vol 25, Iss 13, Pp 1469-1476 (1984)
Rates of sterol synthesis in various tissues commonly are assessed by assaying levels of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase on isolated microsomes or by measuring the rates of incorporation of various 14C-labeled substrates or [3H]wat
Externí odkaz:
https://doaj.org/article/1b703a68c49f48ea90af1bcbaf3380f5
Autor:
D K Spady, J M Dietschy
Publikováno v:
Journal of Lipid Research, Vol 30, Iss 4, Pp 559-569 (1989)
These studies were undertaken to examine the effect of aging on low density lipoprotein (LDL) metabolism in the male hamster. When the hamsters were maintained on a low-cholesterol, low-triglyceride diet, rates of LDL transport in the various tissues
Externí odkaz:
https://doaj.org/article/47fecf4752314cb9a1bd8c66f5122bc6