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Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis

Autor: MA Nielsen, D Køster, S Greisen, A Troldborg, K Stengaard-Pedersen, P Junker, K Hørslev-Petersen, ML Hetland, M Østergaard, M Hvid, H Leffler, TW Kragstrup, B Deleuran

Publikováno v: Nielsen, M A, Køster, D, Greisen, S, Troldborg, A, Stengaard-Pedersen, K, Junker, P, Hørslev-Petersen, K, Hetland, M L, Østergaard, M, Hvid, M, Leffler, H, Kragstrup, T W & Deleuran, B 2023, ' Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis ', Scandinavian Journal of Rheumatology, vol. 52, no. 1, pp. 33-41 . https://doi.org/10.1080/03009742.2021.1992860
Nielsen, M A, Køster, D, Greisen, S, Troldborg, A, Stengaard-Pedersen, K, Junker, P, Hørslev-Petersen, K, Hetland, M L, Østergaard, M, Hvid, M, Leffler, H, Kragstrup, T W & Deleuran, B 2022, ' Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis ', Scandinavian Journal of Rheumatology . https://doi.org/10.1080/03009742.2021.1992860

OBJECTIVE: Galectin-3 (Gal-3) has been suggested as a proinflammatory mediator in rheumatoid arthritis (RA). We aimed to study clinical and pathogenic aspects of Gal-3 in RA.METHOD: Plasma samples from healthy controls (n = 48) and patients with newl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b1cf6eb163f4225f5a8e9dfc201b08

POS0415 PLASMA GALECTIN-9 IS ASSOCIATED WITH CLINICAL DISEASE ACTIVITY IN TREATMENT NAÏVE EARLY RHEUMATOID ARTHRITIS, UNAFFECTED BY DMARD TREATMENT, AND IN VITRO MODULATES THE SECRETION OF MCP-1 AND IL-6 IN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLASTS

Autor: M. A. Nielsen, D. Køster, K. Stengaard-Pedersen, P. Busson, P. Junker, K. Hørslev-Petersen, M. L. Hetland, M. Østergaard, M. Hvid, T. W. Kragstrup, B. Deleuran

Publikováno v: Annals of the Rheumatic Diseases. 81:462.1-463

BackgroundFibroblast-like synoviocytes (FLS) are pivotal mediators of rheumatoid synovitis expansive growth and invasiveness which respond insufficiently to disease-modifying antirheumatic drugs. Galectin-9 (Gal-9) is a lectin with well-conserved car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e946054e8ce3960c457f198acde7d809
https://doi.org/10.1136/annrheumdis-2022-eular.1213

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