Zobrazeno 1 - 4
of 4
pro vyhledávání: '"D K, Spracklin"'
Publikováno v:
Acta anaesthesiologica Scandinavica. 47(6)
Cytochrome P4502E1(CYP2E1)-mediated oxidation of halothane to a reactive intermediate (trifluoroacyl chloride) that covalently binds to hepatic proteins forming trifluoroacetylated neoantigens is believed to be the initiating event in a complex immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c99d6bf0e235051425dcdc35c838358
https://pubmed.ncbi.nlm.nih.gov/12803597
https://pubmed.ncbi.nlm.nih.gov/12803597
Autor:
D K, Spracklin, E D, Kharasch
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d40e12ec282513dc7c9cd96ad453a0f2
https://pubmed.ncbi.nlm.nih.gov/9616199
https://pubmed.ncbi.nlm.nih.gov/9616199
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(1)
The volatile anesthetic halothane undergoes substantial biotransformation generating metabolites that mediate hepatotoxicity. Aerobically, halothane undergoes cytochrome P450-catalyzed oxidation to trifluoroacetic acid (TFA), bromide and a reactive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16d791fd2bd6625cbe98a4567a62bcd2
https://pubmed.ncbi.nlm.nih.gov/9103523
https://pubmed.ncbi.nlm.nih.gov/9103523
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(9)
The anesthetic halothane undergoes extensive oxidative and reductive biotransformation, resulting in metabolites that cause hepatotoxicity. Halothane is reduced anaerobically by cytochrome P450 (P450) to the volatile metabolites 2-chloro-1,1-difluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27f452f4738e48801557b49f1211b51a
https://pubmed.ncbi.nlm.nih.gov/8886607
https://pubmed.ncbi.nlm.nih.gov/8886607