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Leukotriene receptor on U-937 cells: discriminatory responses to leukotrienes C4 and D4

Autor: N. G. Bollinger, D. K. Herron, Norma P. Gerard, Henry A. Feldman, Jeffrey M. Drazen, L. A. Wetmore, S. R. Baker

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 261:L164-L171

Dimethyl sulfoxide (DMSO)-differentiated U-937 cells develop cell surface receptors for leukotrienes that, when stimulated, initiate a transient increase in intracellular calcium concentration [( Ca2+]i). We investigated the calcium transient that oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6e9311a02eb3879abe290cf70495f1
https://doi.org/10.1152/ajplung.1991.261.2.l164

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Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies

Autor: W T, Jackson, L L, Froelich, R J, Boyd, J P, Schrementi, D L, Saussy, R M, Schultz, J S, Sawyer, M J, Sofia, D K, Herron, T, Goodson, D W, Snyder, P A, Pechous, S M, Spaethe, C R, Roman, J H, Fleisch

Publikováno v: The Journal of pharmacology and experimental therapeutics. 288(1)

The in vitro actions were investigated of LY293111, a potent and selective leukotriene B4 (LTB4) receptor antagonist, on human neutrophils, human blood fractions, guinea pig lung membranes, and guinea pig parenchymal and tracheal strips. The IC50 for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::996b6f278ef8a0043be276e322cdd84a
https://pubmed.ncbi.nlm.nih.gov/9862783

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Correlation of molecular shape with GPIIb-IIIa receptor antagonist activity in RGD peptides

Autor: J S, Tung, J A, Jakubowski, W F, Heath, B G, Utterback, D K, Herron

Publikováno v: Receptor. 3(4)

Arg-Gly-Asp-Ser (RGDS) 1, Arg-Val-Asp-Ser (RVDS) 2, Arg-dVal-Asp-Ser (R[d]VDS) 3, and a cyclic RGD peptide, cyclo S,R [H-Pen-Arg-Gly-Asp-Pen-Gly-OH] 4, were tested for their ability to antagonize GPIIb-IIIa function. The activities were found to fall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::757edf7889f03fcd213cbc2aa61a2328
https://pubmed.ncbi.nlm.nih.gov/8142908

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Evaluation of Antibiotic Efficacy Using Electron Microscopy: Morphological Effects of Guanylureido Cephalosporin, BL-P1654, and Carbenicillin on Escherichia coli

Autor: R. A. Schlegel, L. K. Simmons, David A. Preston, D. K. Herron, L. F. Ellis

Publikováno v: Antimicrobial Agents and Chemotherapy. 9:343-346

Early response of Escherichia coli to minimal inhibitory concentrations of 112883, BL-P1654, and carbenicillin was determined by [ 14 C]leucine uptake and scanning electron microscopy morphology studies. [ 14 C]leucine uptake was inhibited later by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6183daf9394e2d4b455fe5755f1aef71
https://doi.org/10.1128/aac.9.2.343

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Leukotriene receptor antagonists. III. Pharmacological and chemical studies with LY137617, a leukotriene D4 and leukotriene E4 receptor antagonist

Autor: D K, Herron, C A, Whitesitt, B E, Mallet, L E, Rinkema, K D, Haisch, J H, Fleisch

Publikováno v: Drugs under experimental and clinical research. 14(5)

A series of chlorophenoxyalkyl acids were prepared and evaluated as pharmacological antagonists of leukotriene D4. Structure-activity relationship studies pointed to LY137617 as a compound with possible therapeutic value. In experiments on isolated s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a8ad8db21728713286906e19304220e4
https://pubmed.ncbi.nlm.nih.gov/2851426

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Leukotrienes (LTB4 and LTD4): in vitro effects on human lymphocyte proliferation and transformation

Autor: J E, Guttery, A, Tilden, D K, Herron, P, Gallagher, S R, Baker, E W, Ades

Publikováno v: Journal of clinicallaboratory immunology. 13(3)

The effects of leukotrienes LTD4 and LTB4 on cell proliferation were assessed in a human in vitro lymphocyte transformation assay in the presence of optimal concentrations of PHA, Con A and PWM. Leukotriene D4 and LTB4 (10(-6) to 10(-11) M) did not a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6615051b016095e01a8fcfbea72c22b0
https://pubmed.ncbi.nlm.nih.gov/6325698

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