Zobrazeno 1 - 10
of 288
pro vyhledávání: '"D James Surmeier"'
Autor:
Michelle Day, Marziyeh Belal, William C Surmeier, Alexandria Melendez, David Wokosin, Tatiana Tkatch, Vernon R J Clarke, D James Surmeier
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002752 (2024)
[This corrects the article DOI: 10.1371/journal.pbio.3002483.].
Externí odkaz:
https://doaj.org/article/67ddbcc9790a4714b11f3e616d0392a4
Autor:
Michelle Day, Marziyeh Belal, William C Surmeier, Alexandria Melendez, David Wokosin, Tatiana Tkatch, Vernon R J Clarke, D James Surmeier
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002483 (2024)
Synaptic transmission mediated by GABAA receptors (GABAARs) in adult, principal striatal spiny projection neurons (SPNs) can suppress ongoing spiking, but its effect on synaptic integration at subthreshold membrane potentials is less well characteriz
Externí odkaz:
https://doaj.org/article/ef860bbfbe264102b49f9ce76eae0b2d
Autor:
Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier
Publikováno v:
eLife, Vol 8 (2019)
Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mech
Externí odkaz:
https://doaj.org/article/6d433a31aa0f4103a04bf72732b8b59c
Publikováno v:
eLife, Vol 6 (2017)
Burst spiking in substantia nigra pars compacta (SNc) dopaminergic neurons is a key signaling event in the circuitry controlling goal-directed behavior. It is widely believed that this spiking mode depends upon an interaction between synaptic activat
Externí odkaz:
https://doaj.org/article/4560a5b3996748758ac4985a347bc5db
Autor:
Jeremy F Atherton, Eileen L McIver, Matthew RM Mullen, David L Wokosin, D James Surmeier, Mark D Bevan
Publikováno v:
eLife, Vol 5 (2016)
The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To
Externí odkaz:
https://doaj.org/article/1ce7a2909744475281264f266529e3b2
Autor:
Chad M Estep, Daniel J Galtieri, Enrico Zampese, Joshua A Goldberg, Lars Brichta, Paul Greengard, D James Surmeier
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0169044 (2016)
Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors. Although activation of GABAA
Externí odkaz:
https://doaj.org/article/32b2a9924b564f8d92964d5ea3a9eac0
Autor:
Tristano Pancani, Michelle Day, Tatiana Tkatch, David L. Wokosin, Patricia González-Rodríguez, Jyothisri Kondapalli, Zhong Xie, Yu Chen, Vahri Beaumont, D. James Surmeier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
The corticostriatal dysfunction underlying Huntington’s disease remains incompletely understood. Here, the authors find increased intratelencephalic connectivity resulting from deficient cholinergic transmission in a mouse model of Huntington’s d
Externí odkaz:
https://doaj.org/article/9f3da2a974ae4bf7836154aa87353185
Autor:
Charles S. Venuto, Luoying Yang, Monica Javidnia, David Oakes, D. James Surmeier, Tanya Simuni
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 3, Pp 603-612 (2021)
Abstract Objectives Isradipine is a dihydropyridine calcium channel inhibitor that has demonstrated concentration‐dependent neuroprotective effects in animal models of Parkinson’s disease (PD) but failed to show efficacy in a phase 3 clinical tri
Externí odkaz:
https://doaj.org/article/cad8337c3ce44e2fb80df69342de98c1
Autor:
Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker S. Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105473- (2021)
CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington's disease and l
Externí odkaz:
https://doaj.org/article/dcb665d27eb248cbbbad7e35d7e418a7
Publikováno v:
Neurobiology of Disease, Vol 156, Iss , Pp 105409- (2021)
Methamphetamine abuse is associated with an increased risk of developing Parkinson's disease (PD). Recently, it was found that methamphetamine increases mitochondrial oxidant stress in substantia nigra pars compacta (SNc) dopaminergic neurons by rele
Externí odkaz:
https://doaj.org/article/496ed4e09a5b4719a2a254b5668168a7