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pro vyhledávání: '"D J Wyler"'
Publikováno v:
The Journal of Immunology. 148:3583-3587
Granulomas that form around Schistosoma mansoni eggs deposited in the liver secrete a variety of fibrogenic factors that may provide a molecular link between chronic inflammation and hepatic fibrogenesis in schistosomiasis. We recently isolated from
Publikováno v:
The Journal of Immunology. 146:1679-1684
Liver fibrosis is the most serious complication of infection with Schistosoma mansoni and Schistosoma japonicum and is responsible for severe morbidity and mortality in hundreds of thousands of patients in many Third World nations. The pathogenesis o
Autor:
D J Wyler, Joseph P. Sypek
Publikováno v:
Infection and Immunity. 58:1146-1152
Using lymph node lymphocytes of Leishmania major-infected mice, we constructed and cloned two T-cell hybridomas that could activate macrophages to exert antileishmanial defense in vitro. One clone, 1D5, produced lymphokines (including gamma interfero
Publikováno v:
The Journal of Immunology. 144:317-322
Schistosomal egg granulomas spontaneously secrete fibrogenic factors, suggesting that there exists a molecular link between granulomatous inflammation and hepatic fibrosis in schistosomiasis. To further assess this possibility, we compared elaboratio
Publikováno v:
Infection and immunity. 61(9)
We compared the abilities of gamma interferon (IFN-gamma), tumor necrosis factor alpha (TNF-alpha), and sensitized murine lymph node lymphocytes to activate syngeneic murine peritoneal macrophages to inhibit the growth of intracellular Mycobacterium
Autor:
S, Prakash, D J, Wyler
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 148(11)
Granulomas that form around Schistosoma mansoni eggs deposited in the liver secrete a variety of fibrogenic factors that may provide a molecular link between chronic inflammation and hepatic fibrogenesis in schistosomiasis. We recently isolated from
Autor:
D J, Wyler
Publikováno v:
Current clinical topics in infectious diseases. 12
Autor:
D J, Wyler
Publikováno v:
The New biologist. 3(8)
The traditional concept of tissue scarring as a static pathological endpoint has been replaced by the modern perspective of a potentially reversible process comprising a sequence of discrete biological events (cell recruitment and hyperplasia, excess
Publikováno v:
Hepatology (Baltimore, Md.). 13(5)
Schistosomiasis is the main cause of hepatic fibrosis worldwide, yet its pathogenesis remains unknown. We previously reported that conditioned medium from cultures of hepatic egg granulomas (isolated from mice acutely infected with Schistosoma manson
Autor:
S, Prakash, D J, Wyler
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 146(5)
Liver fibrosis is the most serious complication of infection with Schistosoma mansoni and Schistosoma japonicum and is responsible for severe morbidity and mortality in hundreds of thousands of patients in many Third World nations. The pathogenesis o