Výsledky vyhledávání - "D J Vidyadhara"

α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease

Autor: Eduardo Martin-Lopez, D. J. Vidyadhara, Teresa Liberia, Sarah J. Meller, Leah E. Harmon, Ryan M. Hsu, Natalie Spence, Bowen Brennan, Kimberly Han, Betül Yücel, Sreeganga S. Chandra, Charles A. Greer

Publikováno v: The Journal of Neuroscience. 43:1051-1071

Parkinson's disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathologic changes in the olfactory pathway of transgenic (Tg) mice of both sexes expressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4443ffc6c5df6b7236a2e6b66d8c6a9c
https://doi.org/10.1523/jneurosci.1526-22.2022

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Akademický článek

Modulation of Autophagy by a Small Molecule Inverse Agonist of ERRα Is Neuroprotective

Autor: S. N. Suresh, Aravinda K. Chavalmane, Malini Pillai, Veena Ammanathan, D. J. Vidyadhara, Haorei Yarreiphang, Shashank Rai, Abhik Paul, James P. Clement, Phalguni A. Alladi, Ravi Manjithaya

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Mechanistic insights into aggrephagy, a selective basal autophagy process to clear misfolded protein aggregates, are lacking. Here, we report and describe the role of Estrogen Related Receptor α (ERRα, HUGO Gene Nomenclature ESRRA), new molecular p

Externí odkaz: https://doaj.org/article/7773f462a4df4bb7a7da10d3bab13297

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Apoptotic factors and mitochondrial complexes assist determination of strain-specific susceptibility of mice to Parkinsonian neurotoxin MPTP

Autor: Haorei Yarreiphang, D J Vidyadhara, Anand Krishnan Nambisan, Trichur R Raju, BK Chandrashekar Sagar, Phalguni Anand Alladi

Identification of genetic mutations in Parkinson’s disease (PD) promulgates the genetic nature of disease susceptibility. Resilience-associated genes being unknown till date, the normal genetic makeup of an individual may be determinative too. Our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a391cf9d0e29ae860554a054865069
https://doi.org/10.1101/2022.10.05.511004

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Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain

Autor: D. J. Vidyadhara, Sreeganga S. Chandra, Sofia Massaro Tieze

Publikováno v: Journal of visualized experiments : JoVE. (187)

Synaptic terminals are the primary sites of neuronal communication. Synaptic dysfunction is a hallmark of many neuropsychiatric and neurological disorders. The characterization of synaptic sub-compartments by biochemical isolation is, therefore, a po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd129330079564a872aee7284c5d4691
https://pubmed.ncbi.nlm.nih.gov/36190269

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Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson’s disease

Autor: D J Vidyadhara, Mahalakshmi Somayaji, Nigel Wade, Betül Yücel, Helen Zhao, N Shashaank, Joseph Ribaudo, Jyoti Gupta, TuKiet T. Lam, Dalibor Sames, Lois E. Greene, David L. Sulzer, Sreeganga S. Chandra

SUMMARYAuxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of- function mutations cause early-onset Parkinson’s disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58eb2bd0f9273f507c775cc96dc58f3b
https://doi.org/10.1101/2022.02.04.479203

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Differences in Neuronal Numbers, Morphology, and Developmental Apoptosis in Mice Nigra Provide Experimental Evidence of Ontogenic Origin of Vulnerability to Parkinson's Disease

Autor: D J, Vidyadhara, Haorei, Yarreiphang, Trichur R, Raju, Phalguni Anand, Alladi

Publikováno v: Neurotoxicity research. 39(6)

Parkinson disease (PD) prevalence varies by ethnicity. In an earlier study, we replicated the reduced vulnerability to PD in an admixed population, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-susceptible C57BL/6 J, MPTP-resistant CD-1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5fdd6ce6dee3759358402edb09e683bb
https://pubmed.ncbi.nlm.nih.gov/34762290

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Differences in Neuronal Numbers, Morphology and Developmental Apoptosis in Mice Nigra Provide Evidence of Ontogenic Origin of Vulnerability to Parkinson’s Disease

Autor: D J Vidyadhara, Haorei Yarreiphang, Trichur R Raju, Phalguni Anand Alladi

Parkinson’s disease (PD) prevalence varies by ethnicity. In an earlier study we replicated the reduced vulnerability to PD in an admixed population, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-susceptible C57BL/6J, MPTP-resistant CD-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75228ba8fdad8a0f3522f4499e3c1256
https://doi.org/10.21203/rs.3.rs-452355/v1

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Prophylactic combined supplementation of choline and docosahexaenoic acid attenuates vascular cognitive impairment and preserves hippocampal cell viability in rat model of chronic cerebral hypoperfusion ischemic brain injury

Autor: K. G. Mohandas Rao, D. J. Vidyadhara, Kiranmai S. Rai, G. Sivakumar, M. G. Ramesh Babu, T. Rajesh, Shivakumar Reddy

Publikováno v: International Journal of Basic and Clinical Pharmacology. :522-530

Background: Stroke is the second cause of mortality in the world and third leading cause of disability in surviving victims. Cerebral ischemic cascade involves multiple pathways that can result in motor and cognitive deficits. The current treatment s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a271d8fe94538fa2e6942634e961af3
https://doi.org/10.18203/2319-2003.ijbcp20150033

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