Zobrazeno 1 - 10 of 23 pro vyhledávání: '"D J Tweats"'
1
Mutation, cancer and transgenic models: relevance to the toxicology industry
Autor: D. J. Tweats, Neil F. Sullivan, D.G. Gatehouse
Publikováno v: Mutagenesis. 8:167-174
The number and structural diversity of new compounds that are currently being introduced into the environment underlies the need to provide more sensitive toxicology tests. Ideally, these should involve tests that reduce dependence upon animal experi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a845c3dbc4f8848337fb00239b3690
https://doi.org/10.1093/mutage/8.3.167
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2
Uptake of tritiated thymidine by cells of the rat gastric mucosa after exposure to loxtidine or omeprazole
Autor: S. Morriss, M. R. M Jackson, D. J. Tweats, D.G. Gatehouse, B. Burlinson
Publikováno v: Mutagenesis. 6:11-18
The H2-antagonist loxtidine and the H+/K(+)-ATPase inhibitor omeprazole inhibit gastric acid secretion and both have been associated with the appearance of gastric tumours in rat cancer studies. Loxtidine is not genotoxic in a range of in vitro and i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61c795fa549201f107b4565ecb714c8
https://doi.org/10.1093/mutage/6.1.11
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3
Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards
Autor: D J, Tweats, D, Blakey, R H, Heflich, A, Jacobs, S D, Jacobsen, T, Morita, T, Nohmi, M R, O'Donovan, Y F, Sasaki, T, Sofuni, R, Tice
Publikováno v: Mutation research. 627(1)
In vivo genotoxicity tests play a pivotal role in genotoxicity testing batteries. They are used both to determine if potential genotoxicity observed in vitro is realised in vivo and to detect any genotoxic carcinogens that are poorly detected in vitr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d4cdeb24c012065b3ee8bf4304ae7b9
https://pubmed.ncbi.nlm.nih.gov/17116417
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4
Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test
Autor: D J, Tweats, D, Blakey, R H, Heflich, A, Jacobs, S D, Jacobsen, T, Morita, T, Nohmi, M R, O'Donovan, Y F, Sasaki, T, Sofuni, R, Tice
Publikováno v: Mutation research. 627(1)
A survey conducted as part of an International Workshop on Genotoxicity Testing (IWGT) has identified a number of compounds that appear to be more readily detected in vivo than in vitro. The reasons for this property varies from compound to compound
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c9e0b52e478fbaad32c37981a6ae806
https://pubmed.ncbi.nlm.nih.gov/17113817
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5
The preclinical toxicological evaluation of sumatriptan
Autor: M.M. Parkinson, D J Tweats, K Owen, K Hartley, M R Jackson, M L Tucker
Publikováno v: Humanexperimental toxicology. 14(12)
1 Sumatriptan is a potent and selective 5-HT1 receptor agonist marketed for the treatment of migraine by both oral and subcutaneous routes. An extensive toxicologi cal programme employing high doses of sumatriptan was carried out in a range of animal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc62dc4c6655171d063b8ab8b7685abb
https://pubmed.ncbi.nlm.nih.gov/8962747
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6
Investigations into the induction of aneuploidy and polyploidy in mammalian cells by the anti-tussive agent noscapine hydrochloride
Autor: P. Wilcox, J. Hawker, D. J. Tweats, G. Stemp, S.A. Pascoe, D.G. Gatehouse
Publikováno v: Mutagenesis. 6(4)
Noscapine, a non-narcotic, centrally-acting anti-tussive drug induces polyploidy in Chinese hamster CHL cells; further studies were carried out to investigate whether similar effects could be induced in other rodent cells (Chinese hamster V79) and in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bad43d29d474ebd903b7b393ad3d658
https://pubmed.ncbi.nlm.nih.gov/1943718
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8
R Factor-mediated Resistance to Ultraviolet Light in Strains of Escherichia coli Deficient in Known Repair Functions
Autor: D. J. Tweats, J. T. Smith, R. J. Pinney, Margaret J. Thompson
Publikováno v: Journal of General Microbiology. 93:103-110
SUMMARY: The expression of resistance to u.v. irradiation mediated by R factor R46 has been studied in strains deficient in excision repair and recombination repair. The R factor protected wild-type bacteria and also wild-type cells in which repair h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45c53330a668ca4ed564bd3b2ebb14a
https://doi.org/10.1099/00221287-93-1-103
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10
Interaction between the plasmid R6K andEscherichia coliwith defective DNA polymerase I
Autor: D. J. Tweats, J. T. Smith
Publikováno v: Genetical Research. 32:25-35
SUMMARYInitial experiments demonstrated that the plasmid R6K cannot be transferred to or maintained readily in theE. coliDNA polymerase I deficient strain JG138polA1. Results withE. coliMM386polA12(R6K), which has a temperature sensitive polymerase I
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3eddb371c8d2ebceb713f413e54bbf1
https://doi.org/10.1017/s0016672300018498
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