Zobrazeno 1 - 10
of 69
pro vyhledávání: '"D J McKean"'
Publikováno v:
Clinical and Experimental Immunology. 145:438-447
SummaryOne of the most difficult laboratory challenges in the field of therapeutic cancer vaccines has been the development of uncomplicated/reproducible methods for the quantification of vaccine immunization efficacy in peripheral blood of cancer pa
Publikováno v:
The Journal of Immunology. 159:5431-5440
Recent molecular evidence points to transient and/or stage-specific expression of delta- and kappa-opioid receptors by thymic and peripheral T lymphocytes. Since medical treatments or stress commonly increase opioid levels, it is important to underst
Publikováno v:
The Journal of Immunology. 146:2952-2959
MHC proteins are polymorphic cell surface glycoproteins involved in the binding of peptide Ag and their presentation to T lymphocytes. The polymorphic amino acids of MHC proteins are primarily located in the N-terminal domains and are thought to infl
Publikováno v:
The Journal of Immunology. 146:2358-2366
To evaluate the potential functional role of the alpha- and beta-chain N-linked oligosaccharides we used site-directed mutagenesis to construct class II Ak alpha and Ak beta genes that encode polypeptides with altered N-linked oligosaccharide accepto
Publikováno v:
The Journal of Immunology. 145:3979-3984
We have evaluated the ability of a peptide-specific, I-Ak-restricted murine T hybridoma to bind its Ag in the presence and absence of class II MHC molecules. The restricting Ia molecule, when supplied as a plasma membrane preparation of I-Ak-expressi
Autor:
L Kerr, C Huntoon, J Donohue, P J Leibson, N H Bander, T Ghose, S J Luner, R Vessella, D J McKean
Publikováno v:
The Journal of Immunology. 144:4060-4067
Tumor cell lysis can be enhanced significantly in vitro when heteroconjugate (HC) antibodies (anti-CD3 x anti-tumor mAb) are used to specifically direct lymphocyte effector cells to the tumor cell target. In order to effectively utilize HC antibodies
Publikováno v:
The Journal of Immunology. 144:1767-1776
Previous studies suggested that the potent immunosuppressive activities of transforming growth factor-beta (TGF-beta) were mediated in part through the inhibition of IL-2-dependent S-phase progression and mitosis of activated T cells. To further inve
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(11)
Recent molecular evidence points to transient and/or stage-specific expression of delta- and kappa-opioid receptors by thymic and peripheral T lymphocytes. Since medical treatments or stress commonly increase opioid levels, it is important to underst
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 154(10)
The endoplasmic reticulum resident protein calnexin interacts with several glycoproteins including class I MHC molecules. Calnexin is thought to retain free class I heavy chains and/or promote their folding and assembly with beta 2-microglobulin and
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 181, iss 1
The Journal of experimental medicine, vol 181, iss 1
The B cell receptor for antigen (BCR) is a complex of membrane immunoglobulin (mIg) and at least two other proteins, Ig alpha (mb-1) and Ig beta (B29). This complex promotes surface expression of the BCR and acts to transduce an activation signal. We