Zobrazeno 1 - 10
of 51
pro vyhledávání: '"D J McConkey"'
Autor:
A B Santamaria, D W Davis, D X Nghiem, D J McConkey, S E Ullrich, M Kapoor, G Lozano, H N Ananthaswamy
Publikováno v:
Cell Death and Differentiation. 9:549-560
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5916b7349033f0e5bae925dd131c2e89
https://doi.org/10.1038/sj/cdd/4401007
https://doi.org/10.1038/sj/cdd/4401007
Publikováno v:
The Journal of Immunology. 156:2624-2630
Therapeutic agents used in the treatment of chronic lymphocytic leukemia (CLL) are capable of inducing apoptosis in some (but not all) patient isolates. It is not yet clear whether cells that are resistant to one agent will also be resistant to other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69142658b3a8f96f1e927a21344a1849
https://doi.org/10.4049/jimmunol.156.7.2624
https://doi.org/10.4049/jimmunol.156.7.2624
Publikováno v:
The Journal of Immunology. 155:5133-5139
Glucocorticoid hormones stimulate apoptosis in thymocytes via a mechanism that involves changes in intracellular Ca2+, and exogenous Ca2+ can also directly promote the nuclear alterations of apoptosis (lamin degradation and chromatin cleavage) in iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::847b2da95dd3ee162c065bd588cf2345
https://doi.org/10.4049/jimmunol.155.11.5133
https://doi.org/10.4049/jimmunol.155.11.5133
Publikováno v:
The Journal of Immunology. 155:4525-4528
The involvement of the glucocorticoid receptor (GR) in cAMP-induced apoptosis in a GR-deficient derivative of the CEM.C7 human T-ALL line was investigated. Incubation of the parental CEM.C7 cells with agents that elevate cAMP levels (dibutyryl cAMP a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a2cd37d977850a7593e921ee43134d
https://doi.org/10.4049/jimmunol.155.10.4525
https://doi.org/10.4049/jimmunol.155.10.4525
Publikováno v:
The Journal of Immunology. 154:3788-3795
Chromatin condensation and nuclear envelope breakdown are characteristic features of apoptotic cell death, but the mechanisms underlying these phenomena have not been identified. Solubilization of nuclear lamin is responsible for both events in mitos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc1109d8d398818eca8ebf91459564a8
https://doi.org/10.4049/jimmunol.154.8.3788
https://doi.org/10.4049/jimmunol.154.8.3788
Autor:
R E Hussey, L K Clayton, A Diener, D J McConkey, F D Howard, H R Rodewald, L D'Adamio, F Dallenbach, H Stein, E V Schmidt
Publikováno v:
The Journal of Immunology. 150:1183-1194
To elucidate the role of CD3 eta in thymic development and to determine whether CD3 eta is involved in the negative selection process, CD3 eta was overexpressed > 100 fold in transgenic (tg) mice using a Thy-1 promoter and regulatory elements. CD3 et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35084c27e8b988e117d996fc0f44bfa1
https://doi.org/10.4049/jimmunol.150.4.1183
https://doi.org/10.4049/jimmunol.150.4.1183
Autor:
D J McConkey, M Aguilar-Santelises, P Hartzell, I Eriksson, H Mellstedt, S Orrenius, M Jondal
Publikováno v:
The Journal of Immunology. 146:1072-1076
Chronic lymphocytic leukemia of B cell type (B-CLL) is a neoplastic disorder characterized by the accumulation of small resting lymphocytes in the periphery. The phenotype of these cells suggests that they are "frozen" at an early stage of maturation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8fb7584f7cd87ab8fca4918389b92e5
https://doi.org/10.4049/jimmunol.146.3.1072
https://doi.org/10.4049/jimmunol.146.3.1072
Publikováno v:
The Journal of Immunology. 145:1227-1230
Increases in the cAMP level are often inhibitory in mature T lymphocytes and may be involved in the development of tolerance to self Ag. In this report, agents inducing an increase in the cAMP level by independent mechanisms were found to stimulate D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::295a6fdf92805c5b5cd7e0e65483b975
https://doi.org/10.4049/jimmunol.145.4.1227
https://doi.org/10.4049/jimmunol.145.4.1227
Publikováno v:
Cancer. 92(5)
Programmed cell death (termed apoptosis) regulates normal tissue homeostasis. Loss of local paracrine signals and intercellular adhesion molecules are potent inducers of apoptosis and thereby eliminate normal cells that may have escaped beyond the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::539525b0dd8f8a5b82775677deea8ca6
https://pubmed.ncbi.nlm.nih.gov/11571724
https://pubmed.ncbi.nlm.nih.gov/11571724
Autor:
J W, Slaton, T, Karashima, P, Perrotte, K, Inoue, S J, Kim, J, Izawa, D, Kedar, D J, McConkey, R, Millikan, P, Sweeney, C, Yoshikawa, T, Shuin, C P, Dinney
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(9)
Tumor invasion and metastasis are regulated by the expression of genes such as E-cadherin, which regulates cell adhesion, and matrix metalloproteinase-9 (MMP-9), which alters the integrity of the extracellular matrix. Both up-regulation of MMP-9 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9530eb6ed4e56ab356882aadc2bebd53
https://pubmed.ncbi.nlm.nih.gov/11555602
https://pubmed.ncbi.nlm.nih.gov/11555602