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Akademický článek

Quantitative comparison of the neutralizing capacity, immunogenicity and cross-reactivity of anti-TNF-α biologicals and an Infliximab-biosimilar.

Autor: D J Buurman, T Blokzijl, E A M Festen, B T Pham, K N Faber, E Brouwer, G Dijkstra

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0208922 (2018)

IntroductionTNF-α-neutralizing antibodies, such as infliximab (IFX) and adalimumab (ADA), are effective in the treatment of inflammatory bowel diseases (IBD), but they are expensive and become ineffective when patients develop anti-IFX or anti-ADA a

Externí odkaz: https://doaj.org/article/ee266d4620e84cd8b0bd9a322485b04a

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Quantitative comparison of the neutralizing capacity, immunogenicity and cross-reactivity of anti-TNF-alpha biologicals and an Infliximab-biosimilar

Autor: Elisabeth Brouwer, Eleonora A. M. Festen, Tjasso Blokzijl, Klaas Nico Faber, B T Pham, Gerard Dijkstra, D. J. Buurman

Publikováno v: PLoS ONE, 13(12):0208922. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 13, Iss 12, p e0208922 (2018)
PLoS ONE

IntroductionTNF-alpha-neutralizing antibodies, such as infliximab (IFX) and adalimumab (ADA), are effective in the treatment of inflammatory bowel diseases (IBD), but they are expensive and become ineffective when patients develop anti-IFX or anti-AD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb120f7a3c4aa9a260892a9c95c65751
https://research.rug.nl/en/publications/9ab36a6e-d90f-4dc9-9b99-b03ba0c0a96f

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Reactivity of 2,3-,2,4- and 3,4-dibromoquinoline towards potassium amide in liquid ammonia

Autor: D. J. Buurman, H. J. den Hertog

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 92:304-310

Aminations of 2,3-, 2,4- and 3,4-dibromoquinoline with potassium amide in different media have been investigated. Reactions of various types (bromine migration, dimerization, cine-substitutions and various ring transformations) were found to occur. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2ad49f512eb5b05885ee7f46627e77b
https://doi.org/10.1002/recl.19730920310

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The use of immobilized enzymes in organic synthesis. Part 6. Oxidation of 1-alkyl-3-carbamoylpyridinium chlorides by rabbit liver aldehyde oxidase

Autor: F. Muller, D. J. Buurman, S.A.G.F. Angelino, H. C. Van Der Plas

Publikováno v: Recueil des travaux chimiques des Pays-Bas = Journal of the Royal Netherlands Chemical Society, 101, 342-346
Recueil des travaux chimiques des Pays-Bas = Journal of the Royal Netherlands Chemical Society 101 (1982)

A method is described for the oxidation of some 1-alkyl-3-carbamoylpyridinium chlorides by reaction with immobilized rabbit liver aldehyde oxidase. With the 1-methyl-, 1-ethyl-and 1-n-propyl derivatives, only the 1-alkyl-1,6-dihydro-6-oxo-3-pyridinec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fb5370e5c35a46805ef15e25eac8cb
https://doi.org/10.1002/recl.19821011005

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Reactivity of aminobromoquinolines towards potassium amide in liquid ammonia

Autor: D. J. Buurman, H. J. den Hertog

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 91:841-849

The isomeric aminobromoquinolines in which amino groups and bromine atoms are attached to the pyridine nucleus were reacted with potassium amide in liquid ammonia at −33°. 2-Amino-3-bromo- and 2-amino-4-bromo-quinoline are converted via 3,4-didehy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d1fb4588db868cf631901b887c66493
https://doi.org/10.1002/recl.19720910711

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The action of p-toluenesulphonyl chloride on pyridine-n-oxide (III)

Autor: H. J. den Hertog, D. J. Buurman, P. A. de Villiers

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 80:325-329

The reaction mixture formed during the heating of pyridine-N-oxide with p-toluenesulphonyl chloride contains, together with pyridine, 2,3′-dipyridyl ether, 3-pyridyl p-toluenesulphonate and N-(2Prime;-pyridyl)-pyridone-2 two chloro compounds, viz.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82e0221e8a87d056665d42d56550de11
https://doi.org/10.1002/recl.19610800311

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Tautomerism of hydroxypyridines (I): The structure of 2,4-dihydroxypyridine

Autor: H. J. den Hertog, D. J. Buurman

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 75:257-264

Syntheses of 2-hydroxy-4-methoxypyridine, 4-hydroxy-2-methoxypyridine, 4-methoxy-N-methylpyridone-2, and 2-methoxy-N-methylpyridone-4 are described. The ultraviolet absorption spectra of 50% aqueous ethanolic solutions of the above-mentioned compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37929d282ec6f7e4432e9fcad2813ecb
https://doi.org/10.1002/recl.19560750304

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The reactivity of pyridine towards sulphuric acid at elevated temperatures

Autor: H. J. den Hertog, H. C. Van Der Plas, D. J. Buurman

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 77:963-971

When pyridine is heated with 100% sulphuric acid in the presence of mercuric sulphate as a catalyst at about 275°, pyridine-3-sulphonic acid is formed as the chief product, together with very small amounts of byproducts. The course of the reaction i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a625ffddf80bfe0c0a76dcfe8ace94ae
https://doi.org/10.1002/recl.19580771010

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The use of immobilized enzymes in organic synthesis. Part 8. Oxidation of 1-aryl-3-carbamoylpyridinium chlorides by rabbit liver aldehyde oxidase and bovine milk xanthine oxidase

Autor: S.A.G.F. Angelino, H. C. Van Der Plas, F. Muller, D. J. Buurman

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 102:331-336

Oxidation of 1-aryl-3-carbamoylpyridinium chlorides with immobilized rabbit liver aldehyde oxidase gave predominantly 1-aryl-1,6-dihydro-6-oxo-3-pyridinecarboxamides, together with the corresponding 1-aryl-1,4-dihydro-4-oxo-3-pyridinecarboxamides. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06e687965fef62fe50c7effb753aab60
https://doi.org/10.1002/recl.19831020610

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Hetarynes XIV: Action of potassium amide on 2-, 3- and 4-bromoquinolines in liquid ammonia

Autor: H. J. den Hertog, D. J. Buurman

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 86:187-192

Both 3- and 4-bromoquinoline when reacted with potassium amide in liquid ammonia, are converted into a mixture of 3- and 4-aminoquinoline probably via 3,4-quinolyne as an intermediate. 2-Bromoquinoline yields together with 2-aminoquinoline, 2-methylq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::833021dc36ca1c9c661267ea26ff3f62
https://doi.org/10.1002/recl.19670860209

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