Zobrazeno 1 - 10
of 114
pro vyhledávání: '"D J Burns"'
Publikováno v:
Fatigue & Fracture of Engineering Materials & Structures. 18:821-831
―Monte Carlo simulations of fatigue in welded joints have been performed using an approach which combines a model for initiation with a multiple surface crack propagation model. The results have been compared with experiments on T-plate welded join
Publikováno v:
Journal of Pressure Vessel Technology. 125:260-266
Fatigue cracks in shot peened and case hardened notched machine components and high-pressure vessels are subjected to the stress fields induced by the external load and the residual stress resulting from the surface treatment or autofrettage. Both st
Autor:
Go Hamasaka, Yasuhiro Uozumi, J Scholz, K Korvorapun, C Jooss, S Warratz, T Rogge, C Zhu, Lutz Ackermann, D Gelman, D J Burns
Publikováno v:
Synfacts. 13:0439
Publikováno v:
Journal of Pressure Vessel Technology. 119:74-82
Mode I weight functions were derived for the deepest and surface points of an external radial-longitudinal semi-elliptical surface crack in a thick-walled cylinder with the ratio of the internal radius to wall thickness, Ri/t = 1.0. Coefficients of a
Publikováno v:
The Journal of Immunology. 157:4641-4647
The intracellular mechanisms that regulate the function of human neutrophils are not well understood. Receptor-initiated signaling events result in the production of several second messengers (e.g., Ca2+, diacylglycerol, phosphatidic acid, and arachi
Autor:
D. J. Burns, Jean A. Mackay, A.A. Ritchie, R. C. F. Leonard, William R. Miller, Jeffrey Cummings, Simon P. Langdon, P.K. Stockman
Publikováno v:
Annals of Oncology. 7:291-296
BACKGROUND 8-Chloroadenosine 3',5'-monophosphate (8-Cl-cAMP) is undergoing phase I clinical trials as an anticancer drug. However, there is debate as to whether it is a prodrug for its 8-Cl-adenosine metabolite. DESIGN Pharmacokinetics, metabolism an
Autor:
J R Falck, R Aneja, L M Ballas, S Aneja, Alex Toker, M Meyer, A Parra, Lewis C. Cantley, K K Reddy, D J Burns
Publikováno v:
Scopus-Elsevier
The effect of phosphoinositides on the activity of protein kinase C (PKC) isotypes was investigated. PKC alpha, beta I, beta II, gamma, delta, epsilon, eta, and zeta were expressed in baculovirus-infected insect cells and purified by column chromatog
Publikováno v:
Journal of Biological Chemistry. 269:21385-21390
In human promyelocytic (HL60) leukemia cells beta II protein kinase C (PKC) is selectively translocated to the nucleus in response to proliferative stimuli. At the nucleus, beta II PKC directly phosphorylates the nuclear envelope polypeptide lamin B
Publikováno v:
Journal of Biological Chemistry. 269:19074-19080
Multisite phosphorylation of the nuclear lamins is thought to regulate the process of mitotic nuclear envelope breakdown in vivo. Here we investigate the involvement of two proposed human mitotic lamin kinases, beta II protein kinase C (PKC) and p34c
Publikováno v:
British Journal of Cancer
The aims of the present study were to characterise an assay for cAMP-binding proteins in ovarian cancer and then to measure levels in a series of tumours with a view to developing a potential prognostic indicator for this disease. Levels and types of