Zobrazeno 1 - 10
of 15
pro vyhledávání: '"D J, Wendt"'
Publikováno v:
Pacing and Clinical Electrophysiology. 18:1686-1704
Summary Antiarrhythmic drugs have relative specificity for blocking each of the major classes of ion channels that control the action potential. The kinetics of block is determined by the state of the channel. Those channel states occupied at depolar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84721cac2eaebea2e0b27bf575543a4
https://doi.org/10.1111/j.1540-8159.1995.tb06990.x
https://doi.org/10.1111/j.1540-8159.1995.tb06990.x
Publikováno v:
Journal of Cardiovascular Pharmacology. 24:803-812
Summary: We examined the relationship between the physicochemical properties and the sodium channelblocking actions of lidocaine and four of its amino-alkyl derivatives. The homologues differ in lipid solubility (log p 2.7-4.1), pKa (6.9-9.0), and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5d8371e98adabd0721ac809458a1b5
https://doi.org/10.1097/00005344-199424050-00016
https://doi.org/10.1097/00005344-199424050-00016
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 264:H1588-H1598
The local anesthetic-class antiarrhythmic drugs produce greater depression of conduction in ischemic compared with normal myocardium. The basis for this relatively selective action is uncertain. A model of the pH-dependent interaction of tertiary ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d24ea491ecd6e127e1759e92ca17080
https://doi.org/10.1152/ajpheart.1993.264.5.h1588
https://doi.org/10.1152/ajpheart.1993.264.5.h1588
Publikováno v:
Journal of Clinical Investigation. 90:368-381
A number of basic and clinical studies suggest that elevation of external sodium concentrations, [Na]o, may reverse the cardiotoxic effect of local anesthetic-class drugs. The mechanisms of reversal are uncertain. The blocking action of lidocaine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379281dc74c3e3e5a00074f7a4c853af
https://doi.org/10.1172/jci115871
https://doi.org/10.1172/jci115871
Publikováno v:
Circulation Research. 70:1254-1273
The recovery of the sodium channel from blockade by local anesthetic antiarrhythmic drugs is voltage dependent. Recovery from lidocaine-induced blockade is accelerated by hyperpolarization, whereas that from glycylxylidide (GX) blockade has been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5eeef83ecea10a1f6b2f13789d4e4c
https://doi.org/10.1161/01.res.70.6.1254
https://doi.org/10.1161/01.res.70.6.1254
Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones
Autor:
D. J. Wendt, Augustus O. Grant
Publikováno v:
Trends in Pharmacological Sciences. 13:352-358
The Na+ channel is an important target for the action of antiarrhythmic drugs. Application of contemporary biophysical, biochemical and molecular biological techniques have added considerably to our knowledge of its structure, function, modulation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0348b6b526b586e412174ecadd7b9a4
https://doi.org/10.1016/0165-6147(92)90108-i
https://doi.org/10.1016/0165-6147(92)90108-i
Autor:
D. J. Wendt, James B. Martins
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 258:H1420-H1426
To characterize autonomic influences on the Purkinje system in vivo, we measured Purkinje relative refractory period (PRRP) in response to sympathetic (SNS) and vagal nerve stimulation (VNS). Effects of SNS on PRRP were primarily mediated via beta-ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb77fdb84dd4c13459f1373e7cdb6aad
https://doi.org/10.1152/ajpheart.1990.258.5.h1420
https://doi.org/10.1152/ajpheart.1990.258.5.h1420
Publikováno v:
Pacing and clinical electrophysiology : PACE. 18(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7c7b5e91253ac4482b25643d8f6ccc
https://pubmed.ncbi.nlm.nih.gov/7479177
https://pubmed.ncbi.nlm.nih.gov/7479177
Publikováno v:
Circulation research. 75(3)
A rise in [K+]o, by depolarizing the resting membrane potential and partially inactivating the inward Na+ current (INa), is believed to play a critical role in slowing conduction during myocardial ischemia. In multicellular ventricular preparations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187c1080a823fa127e1c7f5b3421c370
https://pubmed.ncbi.nlm.nih.gov/8062422
https://pubmed.ncbi.nlm.nih.gov/8062422
Publikováno v:
The Journal of membrane biology. 136(2)
Block of cardiac sodium channels is enhanced by repetitive depolarization. It is not clear whether the changes in drug binding result from a change in affinity that is dependent on voltage or on the actual state of the channel. This question was exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc12057fc34edfb077f69d5de3b287b
https://pubmed.ncbi.nlm.nih.gov/8107074
https://pubmed.ncbi.nlm.nih.gov/8107074