Zobrazeno 1 - 10
of 220
pro vyhledávání: '"D J, Walker"'
Autor:
Timothy S. Fitzsimmons, Niharika Singh, Thomas D. J. Walker, Claire Newton, Dafydd G. R. Evans, Emma J. Crosbie, Neil A. J. Ryan
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundImmune checkpoint inhibitors (ICPI) are a tumor agnostic treatment. However, trials of their use have been site specific. Here we summarize the trial data and explore the utility of programmed death-ligand 1 (PD-L1) expression as a biomarke
Externí odkaz:
https://doaj.org/article/e85e6a4434f447a39ab6c4448e66752b
Autor:
Spyridon Megremis, Thomas D. J. Walker, Xiaotong He, James O’Sullivan, William E. R. Ollier, Hector Chinoy, Neil Pendleton, Antony Payton, Lynne Hampson, Ian Hampson, Janine A. Lamb
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Megremis, Walker at al. identify immunogenic epitopes in dermatomyositis patients. They identify antibodies recognizing a wider diversity of microbial antigens including poxviruses, and autoantibodies recognizing a large portion of the human proteome
Externí odkaz:
https://doaj.org/article/ba4a509bcb374d539d4a36a7507e15fc
Autor:
Thomas D. J. Walker, Zahra F. Faraahi, Marcus J. Price, Amy Hawarden, Caitlin A. Waddell, Bryn Russell, Dominique M. Jones, Aiste McCormick, N. Gavrielides, S. Tyagi, Laura C. Woodhouse, Bethany Whalley, Connor Roberts, Emma J. Crosbie, Richard J. Edmondson
Publikováno v:
Walker, T D J, Faraahi, Z F, Price, M J, Hawarden, A, Waddell, C A, Russell, B, Jones, D M, McCormick, A, Gavrielides, N, Tyagi, S, Woodhouse, L C, Whalley, B, Roberts, C, Crosbie, E J & Edmondson, R J 2023, ' The DNA damage response in advanced ovarian cancer: functional analysis combined with machine learning identifies signatures that correlate with chemotherapy sensitivity and patient outcome ', British Journal of Cancer . https://doi.org/10.1038/s41416-023-02168-3
Background Ovarian cancers are hallmarked by chromosomal instability. New therapies deliver improved patient outcomes in relevant phenotypes, however therapy resistance and poor long-term survival signal requirements for better patient preselection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280700fee921d034c284eae9e468e52
https://doi.org/10.1038/s41416-023-02168-3
https://doi.org/10.1038/s41416-023-02168-3
Autor:
Neal C. Ramchander, Neil A. J. Ryan, Thomas D. J. Walker, Lauren Harries, James Bolton, Tjalling Bosse, D. G. Evans, Emma J. Crosbie
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Around 30% of endometrial cancers (EC) are mismatch repair (MMR) deficient, mostly as a consequence of mutations acquired during tumorigenesis, but a significant minority is caused by Lynch syndrome (LS). This inherited cancer predisposition syndrome
Externí odkaz:
https://doaj.org/article/feb8adc93b1e445eb2b31f037913d8d9
Autor:
James O'Sullivan, Antony Payton, William E R Ollier, Thomas D. J. Walker, Xiaotong He, Janine A. Lamb, Hector Chinoy, Spyridon Megremis, Ian N. Hampson, Neil Pendleton, Lynne Hampson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Megremis, S, Walker, T, He, X, O'Sullivan, J, Ollier, W, Chinoy, H, Pendleton, N, Payton, A, Hampson, L, Hampson, I & Lamb, J 2021, ' Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis ', Communications Biology . https://doi.org/10.1038/s42003-021-01932-6
Communications Biology
Megremis, S, Walker, T, He, X, O'Sullivan, J, Ollier, W, Chinoy, H, Pendleton, N, Payton, A, Hampson, L, Hampson, I & Lamb, J 2021, ' Analysis of human total antibody repertoires in TIF1γ autoantibody positive dermatomyositis ', Communications Biology . https://doi.org/10.1038/s42003-021-01932-6
Communications Biology
We investigate the accumulated microbial and autoantigen antibody repertoire in adult-onset dermatomyositis patients sero-positive for TIF1γ (TRIM33) autoantibodies. We use an untargeted high-throughput approach which combines immunoglobulin disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d1b870991e5a7e3c23a74e252582a3
https://doaj.org/article/ba4a509bcb374d539d4a36a7507e15fc
https://doaj.org/article/ba4a509bcb374d539d4a36a7507e15fc
Autor:
Thomas D. J. Walker, Xiaotong He, Hector Chinoy, William E R Ollier, Janine A. Lamb, Lynne Hampson, Ian N. Hampson, Spyridon Megremis
Publikováno v:
Annals of the Rheumatic Diseases
Megremis, S, Walker, T, He, X, Ollier, W, Chinoy, H, Hampson, L, Hampson, I & Lamb, J 2020, ' Antibodies against immunogenic epitopes with high sequence identity to SARS-CoV-2 in patients with autoimmune dermatomyositis ', Annals Of Rheumatic Diseases . https://doi.org/10.1136/annrheumdis-2020-217522
Megremis, S, Walker, T, He, X, Ollier, W, Chinoy, H, Hampson, L, Hampson, I & Lamb, J 2020, ' Antibodies against immunogenic epitopes with high sequence identity to SARS-CoV-2 in patients with autoimmune dermatomyositis ', Annals Of Rheumatic Diseases . https://doi.org/10.1136/annrheumdis-2020-217522
Idiopathic inflammatory myopathies (IIMs) are rare, heterogeneous, autoimmune musculoskeletal diseases, characterised clinically by muscle weakness. Extramuscular involvement includes the skin, respiratory and cardiovascular systems. Genetic and envi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f629bc48736a0a61a1d3766315d2d211
https://doi.org/10.1136/annrheumdis-2020-217522
https://doi.org/10.1136/annrheumdis-2020-217522
Publikováno v:
Biologia Plantarum, Vol 54, Iss 2, Pp 293-298 (2010)
We determined the cold (freezing) tolerance of five Spanish populations of the perennial shrub Bituminaria bituminosa (L.) C.H. Stirton (Fabaceae), as the temperature at which 50 % of leaf electrolytes are released (LT50) using leaves of field-grown
Externí odkaz:
https://doaj.org/article/ea9b72a2f51b43b8b41ff965b80022ad
Autor:
Tjalling Bosse, Thomas D. J. Walker, D. Gareth Evans, James Bolton, Tom van Wezel, Natalja T. ter Haar, Neil A J Ryan, Mark A. Glaire, David N. Church, Emma J Crosbie
Publikováno v:
Cancers, 13(18). MDPI
Cancers
Ryan, N A J, Walker, T D J, Bolton, J, Haar, N T, Wezel, T V, Glaire, M A, Church, D N, Evans, D G, Bosse, T & Crosbie, E J 2021, ' Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies ', Cancers . https://doi.org/10.3390/cancers13184538
Cancers, Vol 13, Iss 4538, p 4538 (2021)
Ryan, N A J, Walker, T D J, Bolton, J, Haar, N T, Wezel, T V, Glaire, M A, Church, D N, Evans, D G, Bosse, T & Crosbie, E J 2021, ' Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies ', Cancers, vol. 13, no. 18, 4538 . https://doi.org/10.3390/cancers13184538
Volume 13
Issue 18
Cancers
Ryan, N A J, Walker, T D J, Bolton, J, Haar, N T, Wezel, T V, Glaire, M A, Church, D N, Evans, D G, Bosse, T & Crosbie, E J 2021, ' Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies ', Cancers . https://doi.org/10.3390/cancers13184538
Cancers, Vol 13, Iss 4538, p 4538 (2021)
Ryan, N A J, Walker, T D J, Bolton, J, Haar, N T, Wezel, T V, Glaire, M A, Church, D N, Evans, D G, Bosse, T & Crosbie, E J 2021, ' Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies ', Cancers, vol. 13, no. 18, 4538 . https://doi.org/10.3390/cancers13184538
Volume 13
Issue 18
Background: Mismatch repair deficient (MMRd) tumours may arise from somatic events acquired during carcinogenesis or in the context of Lynch syndrome (LS), an inherited cancer predisposition condition caused by germline MMR pathogenic variants. Our a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198b95d5a4a5b6489c7d610fb4fa01ac
http://hdl.handle.net/1887/3250658
http://hdl.handle.net/1887/3250658
Autor:
Y Louise Wan, B Russell, Thomas D. J. Walker, Ellena Badrick, Iman El Sayed, Emma J Crosbie, Alexandra McAleenan, Richard J. Edmondson
Publikováno v:
Cochrane Database Syst Rev
Wan, Y L, El Sayed, I, Walker, T DJ, Russell, B, Badrick, E, McAleenan, A S J, Edmondson, R & Crosbie, E J 2021, ' Prognostic models for predicting recurrence and survival in women with endometrial cancer ', Cochrane Database of Systematic Reviews, vol. 2021, no. 6, CD014625 . https://doi.org/10.1002/14651858.CD014625
Wan, Y-L, El Sayed, I, Walker, T, Russell, B, Badrick, E, McAleenan, A, Edmondson, R & Crosbie, E 2021, ' Prognostic models for predicting recurrence and survival in women with endometrial cancer ', The Cochrane Library, vol. 2021, no. 6, CD014625 . https://doi.org/10.1002/14651858.cd014625
Wan, Y L, El Sayed, I, Walker, T DJ, Russell, B, Badrick, E, McAleenan, A S J, Edmondson, R & Crosbie, E J 2021, ' Prognostic models for predicting recurrence and survival in women with endometrial cancer ', Cochrane Database of Systematic Reviews, vol. 2021, no. 6, CD014625 . https://doi.org/10.1002/14651858.CD014625
Wan, Y-L, El Sayed, I, Walker, T, Russell, B, Badrick, E, McAleenan, A, Edmondson, R & Crosbie, E 2021, ' Prognostic models for predicting recurrence and survival in women with endometrial cancer ', The Cochrane Library, vol. 2021, no. 6, CD014625 . https://doi.org/10.1002/14651858.cd014625
Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. To review all prognostic models that combine two or more clinical, histological or molecular variables, or a combination of these variables, to provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e553dd3b9fc9ca71bf8090327a5e12
https://europepmc.org/articles/PMC8202229/
https://europepmc.org/articles/PMC8202229/
Autor:
Anie, Naqvi, Michelle L, MacKintosh, Abigail E, Derbyshire, Anna-Maria, Tsakiroglou, Thomas D J, Walker, Rhona J, McVey, James, Bolton, Martin, Fergie, Steven, Bagley, Garry, Ashton, Philip W, Pemberton, Akheel A, Syed, Basil J, Ammori, Richard, Byers, Emma J, Crosbie
Publikováno v:
International journal of obesity (2005). 46(3)
The incidence of endometrial cancer is rising in parallel with the obesity epidemic. Obesity increases endometrial cancer risk and weight loss is protective, but the underlying mechanisms are incompletely understood. We hypothesise that the immune mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfe9657eac0a8683aa1ceb7d269950de
https://pubmed.ncbi.nlm.nih.gov/34857870
https://pubmed.ncbi.nlm.nih.gov/34857870