Zobrazeno 1 - 10
of 52
pro vyhledávání: '"D J, Wagener"'
Cancer cachexia: what is known about its etiology and what should be the current treatment approach?
Publikováno v:
Anticancer research. 23(6D)
Cancer cachexia, defined as involuntary weight loss and tissue wasting due to cancer, negatively influences physical condition, quality of life and prognosis. Well known causes, such as ileus or hypercalcemia, do not suffice to explain the entire phe
Autor:
D J, Wagener
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 11
Publikováno v:
Anticancer research. 20(3A)
Resistance to chemotherapeutic agents is a major problem in the treatment of patients with gastric cancer. Many factors may play a role in the resistance to cytotoxic drugs. The purpose of this study was to investigate the significance of glutathione
Autor:
D I, Schipper, M J, Wagenmans, W H, Peters, U, Van Haelst, T, Wobbes, A A, Verhofstad, D J, Wagener
Publikováno v:
Anticancer research. 16(6B)
Glutathione S-transferases (GSTs) are enzymes involved in the detoxification of xenobiotics and are divided into four subclasses. Alpha, Mu, Pi and Theta. Most human gastrointestinal tumors contain increased amounts of GST Pi. In order to compare dat
Autor:
D L, Schipper, M J, Wagenmans, U, Van Haelst, W H, Peters, T, Wobbes, A A, Verhofstad, W P, Lange, D J, Wagener
Publikováno v:
Anticancer research. 16(2)
Glutathione S-transferases (GSTs) are a family of isoenzymes that play an important role in protecting cells against cytotoxic and carcinogenic agents. The distribution and levels of GST Alpha and Pi in normal and malignant gastric tissue of 34 patie
Publikováno v:
The Netherlands journal of medicine. 46(3)
The results of palliative chemotherapy with cyclophosphamide, methotrexate and 5-fluorouracil (CMF) in patients with advanced breast cancer who received adjuvant therapy with the same regimen were investigated.Of 47 patients, 14 (30%) achieved an obj
Publikováno v:
Cancer research. 54(16)
High-resolution 19F nuclear magnetic resonance spectroscopy at 7 T was used to study the effect of modulators on the metabolism of 5-fluorouracil (5-FUra, 115 mg/kg i.p.) in C38 murine colon tumors grown in C57BL/6 mice. Distinct 5-FUra metabolite pa
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 5
Pancreatic cancer is associated with an extremely poor prognosis. Even after resection with curative intent, the 5-year survival rates usually do not exceed 5%, and neither radiotherapy (RT) nor chemotherapy (CT) improve long term survival. Because o
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 5
The prognosis of locally advanced pancreatic cancer is poor (median survival 3-5 months). In view of the localized character of this disease several groups have explored the value of combined modality treatment. The conditions are that a good local t
Autor:
T, Conroy, J, Wils, B, Paillot, D J, Wagener, J T, Burghouts, M M, Fickers, A, de Graeff, F M, Lalisang
Publikováno v:
Bulletin du cancer. 80(3)
In this phase II study, fifty patients with unresectable locally advanced and/or metastatic gastric carcinoma were treated with methotrexate 1.5 g/m2 iv and 5-fluorouracil 1.5 g/m2 iv on day 1; leucovorin rescue 15 mg/m2 orally every 6 h for 8 doses