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pro vyhledávání: '"D J, Spiegelhalter"'
Autor:
D J, Spiegelhalter
Publikováno v:
Science (New York, N.Y.). 345(6194)
Publikováno v:
BMJ. 316:1701-1705
Objective: To determine to what extent institutions carrying out in vitro fertilisation can reasonably be ranked according to their live birth rates. Design: Retrospective analysis of prospectively collected data on live birth rate after in vitro fer
Autor:
D J, Spiegelhalter
Publikováno v:
Statistics in medicine. 20(3)
Bayesian methods for cluster randomized trials extend the random-effects formulation by allowing both the use of external evidence on parameters and straightforward relaxation of the standard normality and constant variance assumptions. Care is requi
Publikováno v:
Health Technology Assessment, Vol 4, Iss 38 (2000)
Bayesian methods may be defined as the explicit quantitative use of external evidence in the design, monitoring, analysis, interpretation and reporting of a health technology assessment. In outline, the methods involve formal combination through the
Publikováno v:
Journal of epidemiology and biostatistics. 4(1)
The reluctance to perform randomised trials on still unresolved issues of the cervical screening programme is largely due to the view that using invasive cancer as an end-point would require huge and lengthy studies. However, by assuming that the inc
Autor:
K, Bull, D J, Spiegelhalter
Publikováno v:
Statistics in medicine. 16(9)
Multi-centre databases are making an increasing contribution to medical understanding. While the statistical handling of randomized experimental studies is well documented in the medical literature, the analysis of observational studies requires the
Publikováno v:
Transplantation. 62(10)
We have attempted to quantify the optimal clinical use of cyclosporine during the first 3 months after heart-lung transplantation. We used multiple logistic regression to investigate the influence of blood cyclosporine concentrations and other potent
Publikováno v:
Transplantation. 62(10)
We have attempted to determine the optimal clinical use of cyclosporine during the first 3 months after heart transplantation. We used multiple logistic regression to quantify how blood cyclosporine concentrations and other potential risk factors inf
Publikováno v:
Statistics in medicine. 15(2)
Classification trees provide an attractively transparent discrimination technique, and may be derived from both expert opinion and from data analysis. We consider a real and complex problem concerning the diagnosis of babies with suspected critical c
Publikováno v:
Statistics in medicine. 13(13-14)
In this paper we describe the design and monitoring of two large randomized trials being conducted through the British Medical Research Council (MRC) Cancer Trials Office. In particular we discuss the issues involved in the design of the trials, spec