Zobrazeno 1 - 4
of 4
pro vyhledávání: '"D J, Rogier"'
Autor:
John J. Talley, Matthew J. Graneto, Jeffery S. Carter, Yan Zhang, Carol M. Koboldt, D. J. Rogier, Karen Seibert
Publikováno v:
ChemInform. 30
A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b80bc47e9bff12489947feb4bd23d0c
https://doi.org/10.1002/chin.199932122
https://doi.org/10.1002/chin.199932122
Autor:
D. J. Rogier, John J. Talley, Jeffery S. Carter, Matthew J. Graneto, Carol M. Koboldt, Yan Zhang, Karen Seibert
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(8)
A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe44ca0e02e9f820eea433a0a5cd19cf
https://pubmed.ncbi.nlm.nih.gov/10328306
https://pubmed.ncbi.nlm.nih.gov/10328306
Autor:
J J, Talley, S R, Bertenshaw, D L, Brown, J S, Carter, M J, Graneto, C M, Koboldt, J L, Masferrer, B H, Norman, D J, Rogier, B S, Zwwifel, K, Seibert
Publikováno v:
Medicinal research reviews. 19(3)
A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b6e37488c953294ab3e1518e1941a15d
https://pubmed.ncbi.nlm.nih.gov/10232649
https://pubmed.ncbi.nlm.nih.gov/10232649
Autor:
Karen Seibert, AndersonGD, John J. Talley, Susan A. Gregory, Matthew J. Graneto, Yan Y. Zhang, James W. Malecha, Len F. Lee, Stella S. Yu, Stephen H. Docter, Bertenshaw, P. C. Isakson, P. W. Collins, E. G. Burton, J. N. Cogburn, Jeffery S. Carter, A. W. Veenhuizen, Carol M. Koboldt, T. D. Penning, Julie M. Miyashiro, D. J. Rogier, W E Perkins, Roland S. Rogers
Publikováno v:
Journal of medicinal chemistry. 40(9)
A series of sulfonamide-containing 1,5-diarylpyrazole derivatives were prepared and evaluated for their ability to block cyclooxygenase-2 (COX-2) in vitro and in vivo. Extensive structure-activity relationship (SAR) work was carried out within this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bb0795084059f20068b91d6f051cfb
https://pubmed.ncbi.nlm.nih.gov/9135032
https://pubmed.ncbi.nlm.nih.gov/9135032