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Autor:
R B, Lingham, K C, Silverman, H, Jayasuriya, B M, Kim, S E, Amo, F R, Wilson, D J, Rew, M D, Schaber, J D, Bergstrom, K S, Koblan, S L, Graham, N E, Kohl, J B, Gibbs, S B, Singh
Publikováno v:
Journal of medicinal chemistry. 41(23)
We have identified a novel fungal metabolite that is an inhibitor of human farnesyl-protein transferase (FPTase) by randomly screening natural product extracts using a high-throughput biochemical assay. Clavaric acid [24, 25-dihydroxy-2-(3-hydroxy-3-