Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)

Autor: G, Davies, R E, Marioni, D C, Liewald, W D, Hill, S P, Hagenaars, S E, Harris, S J, Ritchie, M, Luciano, C, Fawns-Ritchie, D, Lyall, B, Cullen, S R, Cox, C, Hayward, D J, Porteous, J, Evans, A M, McIntosh, J, Gallacher, N, Craddock, J P, Pell, D J, Smith, C R, Gale, I J, Deary

Publikováno v: Davies, G, Marioni, R E, Liewald, D C, Hill, W D, Hagenaars, S P, Harris, S E, Ritchie, S J, Luciano, M, Fawns-Ritchie, C, Lyall, D, Cullen, B, Cox, S R, Hayward, C, Porteous, D J, Evans, J, Mcintosh, A M, Gallacher, J, Craddock, N, Pell, J P, Smith, D J, Gale, C R & Deary, I J 2016, ' Genome-wide association study of cognitive functions and educational attainment in UK Biobank ( N =112 151) ', Molecular Psychiatry, vol. 21, no. 6, pp. 758-767 . https://doi.org/10.1038/mp.2016.45
Molecular Psychiatry

People’s differences in cognitive functions are partly heritable and are associated with important life outcomes. Previous genome-wide association (GWA) studies of cognitive functions have found evidence for polygenic effects yet, to date, there ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c9140328e2face379956997bb121d81f
https://ora.ox.ac.uk/objects/uuid:5723f54c-bcaf-423c-b5e0-df6adc911665

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts

Autor: H C, Whalley, M J, Adams, L S, Hall, T-K, Clarke, A M, Fernandez-Pujals, J, Gibson, E, Wigmore, J, Hafferty, S P, Hagenaars, G, Davies, A, Campbell, C, Hayward, S M, Lawrie, D J, Porteous, I J, Deary, A M, McIntosh

Publikováno v: Translational Psychiatry

Major depressive disorder (MDD) is known for its substantial clinical and suspected causal heterogeneity. It is characterized by low mood, psychomotor slowing and increased levels of the personality trait neuroticism; factors also associated with sch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c34fe4f663758c2c3a364b6787b2ea2e
https://pubmed.ncbi.nlm.nih.gov/27801894

Does a history of depression actually mediate smoking-related pain? Findings from a cross-sectional general population-based study

Autor: O, van Hecke, N, Torrance, L, Cochrane, J, Cavanagh, P T, Donnan, S, Padmanabhan, D J, Porteous, L, Hocking, B H, Smith

Publikováno v: European journal of pain (London, England). 18(9)

Smokers report more pain and worse functioning. The evidence from pain clinics suggests that depression affects this relationship: The association between smoking and chronic pain is weakened when controlling for depression. This study explored the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bf2f2443dcd00bca1566f510bdb8e1e
https://pubmed.ncbi.nlm.nih.gov/24577799

Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Autor: D M, Lyall, S E, Harris, M E, Bastin, S, Muñoz Maniega, C, Murray, M W, Lutz, A M, Saunders, A D, Roses, M del C, Valdés Hernández, N A, Royle, J M, Starr, D J, Porteous, J M, Wardlaw, I J, Deary

Publikováno v: Translational Psychiatry

Genetic polymorphisms in the APOE ɛ and TOMM40 '523' poly-T repeat gene loci have been associated with significantly increased risk of Alzheimer's disease. This study investigated the independent effects of these polymorphisms on human cognitive age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14d722acc83ccfe6b42a33e4916fee30
https://pubmed.ncbi.nlm.nih.gov/25247594

Heritability of chronic pain in 2195 extended families

Autor: L J, Hocking, A D, Morris, A F, Dominiczak, D J, Porteous, Alan, Wright

Publikováno v: European journal of pain (London, England). 16(7)

Chronic pain is pathological, persisting beyond normal tissue healing time. Previous work has suggested ∼50% variation in chronic pain development is heritable. No data are currently available on the heritability of pain categorized using the Chron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::323dfe58bbbe8e3fc264036a22ee05f5
https://pubmed.ncbi.nlm.nih.gov/22337623