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Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum)

Autor: K A, Peebles, R K, Baker, E U, Kurz, B J, Schneider, D J, Kroll

Publikováno v: Biochemical pharmacology. 62(8)

St. John's wort (Hypericum perforatum) is the most widely used herbal medicine for the treatment of depression. However, concerns have arisen about the potential of its interaction with other drugs due to the induction of cytochrome P450 isozymes 1A2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c670b684c5866dd42fb53a3f5af5e645
https://pubmed.ncbi.nlm.nih.gov/11597574

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Ligand-dependent interaction of hepatic fatty acid-binding protein with the nucleus

Autor: J W, Lawrence, D J, Kroll, P I, Eacho

Publikováno v: Journal of lipid research. 41(9)

Our studies were conducted to explore the role of hepatic fatty acid-binding protein (L-FABP) in fatty acid transport to the nucleus. Purified rat L-FABP facilitated the specific interaction of [(3)H]oleic acid with the nuclei. L-FABP complexed with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87a7a9f90f66d278143ddc7bb378be5c
https://pubmed.ncbi.nlm.nih.gov/10974046

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Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon

Autor: E U, Kurz, K B, Leader, D J, Kroll, M, Clark, F, Gieseler

Publikováno v: The Journal of biological chemistry. 275(18)

Human DNA topoisomerase IIalpha (topo II), a ubiquitous nuclear enzyme, is essential for normal and neoplastic cellular proliferation and survival. Several common anticancer drugs exert their cytotoxic effects through interaction with topo II. In exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5ae285c8ccfa3b7dc908a66f68dd236
https://pubmed.ncbi.nlm.nih.gov/10788521

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Long chain arginine esters: a new class of cationic detergents for preparation of hydrophobic ion-paired complexes

Autor: D J, Claffey, J D, Meyer, R, Beauvais, T, Brandt, E, Shefter, D J, Kroll, J A, Ruth, M C, Manning

Publikováno v: Biochemistry and cell biology = Biochimie et biologie cellulaire. 78(1)

The ability of stoichiometric amounts (based on charged groups) of ionic detergents to bind to oppositely charged ionic compounds has been recently reviewed. These hydrophobic ion-paired (HIP) complexes display altered solubility properties. Most of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55cc6afac79151bfaf722396cb1ef66d
https://pubmed.ncbi.nlm.nih.gov/10735564

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Alpha, beta-unsaturated aldehydes mediate inducible expression of glutathione S-transferase in hepatoma cells through activation of the antioxidant response element (ARE)

Autor: R B, Tjalkens, S W, Luckey, D J, Kroll, D R, Petersen

Publikováno v: Advances in experimental medicine and biology. 463

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::299ec2ceada65d33a8fa4f136866e03b
https://pubmed.ncbi.nlm.nih.gov/10352677

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Topoisomerase II alpha promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells

Autor: D J, Fraser, T L, Brandt, D J, Kroll

Publikováno v: Molecular pharmacology. 47(4)

The cytotoxic efficacy of antitumor drugs targeted at DNA topoisomerase II (topo II) in many cases varies in direct proportion to cellular topo II content. To investigate the transcriptional control of the predominant alpha form of topo II, the 5' fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eaf15730256046470405d4ec8112169a
https://pubmed.ncbi.nlm.nih.gov/7723730

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Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2: interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation

Autor: H A, Abdel-Hafiz, C Y, Chen, T, Marcell, D J, Kroll, J P, Hoeffler

Publikováno v: Oncogene. 8(5)

Dimerization of leucine zipper-containing proteins has been associated characteristically with the formation of a coiled-coil structure between two compatible leucine zipper motifs. In the present study we demonstrate the association of the leucine z

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4af8882ab0dc4e02db673f0df6bf1c59
https://pubmed.ncbi.nlm.nih.gov/8479741

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Phosphorylation of DNA topoisomerase II in a human tumor cell line

Autor: D J, Kroll, T C, Rowe

Publikováno v: The Journal of biological chemistry. 266(12)

The phosphorylation of the nuclear enzyme DNA topoisomerase II was characterized from HeLa human cervical carcinoma cells labeled with 32Pi. Analysis of topoisomerase II immunoprecipitates from 32P-labeled HeLa cells indicated that phosphorylation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a9729f70fb1dda6f2bd61dd9ced895e9
https://pubmed.ncbi.nlm.nih.gov/1850428

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Drug sensitivity of heat-resistant mouse B16 melanoma variants

Autor: D J, Kroll, C J, Borgert, T W, Wiedmann, T C, Rowe

Publikováno v: Radiation research. 124(1)

Induction of transient thermotolerance by heat or other cytotoxic stressors has been reported to confer a moderate degree of drug resistance to tumor cells in vitro. In this study, a genetically stable, heat-resistant mouse B16 melanoma variant (W-H7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09d4c37c4f7be76ce0e1ae4e408b28a5
https://pubmed.ncbi.nlm.nih.gov/2236492

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