Zobrazeno 1 - 7 of 7 pro vyhledávání: '"D J, Kornbrust"'
1
Activation of the alternative pathway of complement by a phosphorothioate oligonucleotide: potential mechanism of action
Autor: S P, Henry, P C, Giclas, J, Leeds, M, Pangburn, C, Auletta, A A, Levin, D J, Kornbrust
Publikováno v: The Journal of pharmacology and experimental therapeutics. 281(2)
Intravenous infusion of high doses of phosphorothioate oligonucleotides in monkeys has been associated with transient alterations in hematologic and hemodynamic parameters, which appear to be secondary to complement activation. ISIS 2302, a phosphoro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80e4ace280958160e28e4a48c86252d2
https://pubmed.ncbi.nlm.nih.gov/9152389
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2
Single-dose hemodynamic toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after intravenous infusion to cynomolgus monkeys
Autor: T L, Wallace, S A, Bazemore, D J, Kornbrust, P A, Cossum
Publikováno v: The Journal of pharmacology and experimental therapeutics. 278(3)
5' GTGGTGGGTGGGTGGGT-3' (AR177) is a 17-mer oligonucleotide with anti-human immunodeficiency virus (HIV) activity that is composed of a phosphodiester backbone and single phosphorothioate linkages at the 3' and 5' ends. A hemodynamic toxicity study w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9310a0fa1558ebe557dbbc33aa462851
https://pubmed.ncbi.nlm.nih.gov/8819516
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3
Repeat-dose toxicity and pharmacokinetics of a partial phosphorothioate anti-HIV oligonucleotide (AR177) after bolus intravenous administration to cynomolgus monkeys
Autor: T L, Wallace, S A, Bazemore, D J, Kornbrust, P A, Cossum
Publikováno v: The Journal of pharmacology and experimental therapeutics. 278(3)
5'GTGGTGGGTGGGTGGGT-3' (AR177) is a partial phosphorothioate, 17-mer oligonucleotide that has been shown to have anti-human immunodeficiency virus (HIV) activity in vitro and to be a potent inhibitor of HIV-1 integrase. A repeat-dose toxicity and pha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2b031f6452c7ff0c09613e9d4cf6f17
https://pubmed.ncbi.nlm.nih.gov/8819517
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4
Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits
Autor: D J, Kornbrust, J S, MacDonald, C P, Peter, D M, Duchai, R J, Stubbs, J I, Germershausen, A W, Alberts
Publikováno v: The Journal of pharmacology and experimental therapeutics. 248(2)
Lovastatin, a specific inhibitor of the rate-limiting enzyme in cholesterol biosynthesis, HMG-CoA reductase, has been shown to be highly effective in lowering serum cholesterol in animals and humans and thus represents a promising approach to the tre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::82235124728c3b6996ca18a83a965c17
https://pubmed.ncbi.nlm.nih.gov/2918466
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6
Variations on the standard protocol design of the hepatocyte DNA repair assay
Autor: D. J. Kornbrust, T. R. Barfknecht, R. W. Naismith
Publikováno v: Cell biology and toxicology. 3(2)
Several variations on the standard primary rat hepatocyte DNA/repair assay were evaluated for their ability to enhance the sensitivity of this genotoxicity test system. The use of hamster hepatocytes proved to be a much more sensitive system than rat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0968110d5dcacc67a2f59c001169b8
https://pubmed.ncbi.nlm.nih.gov/3507255
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