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Differences detected in vivo between samples of aflatoxincontaminated peanut meal, following decontamination by two ammonia-based processes

Autor: G. E. Neal, M. J. Nagler, Laurentius Hoogenboom, P. Carthew, L. Weir, A. Verma, R. D. Coker, I. Latour, D. J. Judah

Publikováno v: Food Additives and Contaminants, 18(2), 137-149
Food Additives and Contaminants 18 (2001) 2

A sample of peanut meal, highly contaminated with aflatoxins, has been subjected to decontamination by two commercial ammonia-based processes. The original contaminated and the two decontaminated meals were fed to rats for 90 days. No lesions associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23521cd88af893d86c576b654ba9adb
https://doi.org/10.1080/02652030010011379

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Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1

Autor: John D. Hayes, D J Judah, D G Petersson, T Nguyen, G.E. Neal

Publikováno v: Journal of Biological Chemistry. 269:20707-20717

Fetal rat liver possesses substantial levels of glutathione S-transferase (GST) activity toward aflatoxin B1-8,9-epoxide. The enzyme responsible for this activity is an Alpha-class GST heterodimer comprising Yc1 and Yc2 subunits. The cDNAs encoding t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e4b2402a9230cb1d55a38029e6f0167
https://doi.org/10.1016/s0021-9258(17)32050-1

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Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver

Autor: V P, Kelly, E M, Ellis, M M, Manson, S A, Chanas, G J, Moffat, R, McLeod, D J, Judah, G E, Neal, J D, Hayes

Publikováno v: Cancer research. 60(4)

Structurally diverse compounds can confer resistance to aflatoxin B1 (AFB1) hepatocarcinogenesis in the rat. Treatment with either phytochemicals [benzyl isothiocyanate, coumarin (CMRN), or indole-3-carbinol] or synthetic antioxidants and other drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9b42182e691225823c5edffb478a6ba
https://pubmed.ncbi.nlm.nih.gov/10706111

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Metabolism and toxicity of aflatoxins M1 and B1 in human-derived in vitro systems

Autor: A. Verma, G. E. Neal, David L. Eaton, D. J. Judah

Publikováno v: Toxicology and applied pharmacology. 151(1)

Aflatoxin M 1 (AFM 1 ) is the principal hydroxylated aflatoxin metabolite present in the milk of dairy cows fed a diet contaminated with aflatoxin B 1 , (AFB 1 ) and the metabolite is also present in the milk of human nursing mothers consuming foodst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f9f8977fd6c8e4eaf9d22f13c136fc
https://pubmed.ncbi.nlm.nih.gov/9705898

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Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin

Autor: R, McLeod, E M, Ellis, J R, Arthur, G E, Neal, D J, Judah, M M, Manson, J D, Hayes

Publikováno v: Cancer research. 57(19)

Fischer 344 rats fed on a diet that is deficient in selenium are more resistant to the hepatocarcinogen aflatoxin B1 (AFB1) than those fed on a selenium-sufficient diet. Hepatic cytosol from either selenium-deficient Fischer 344 rats or Hooded Lister

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::26741a67da563c18d5472922aad6e951
https://pubmed.ncbi.nlm.nih.gov/9331086

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Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to aflatoxin B1

Autor: J D, Hayes, R, McLeod, E M, Ellis, D J, Pulford, L S, Ireland, L I, McLellan, D J, Judah, M M, Manson, G E, Neal

Publikováno v: IARC scientific publications. (139)

A number of xenobiotics, including the synthetic antioxidant ethoxyquin, inhibit aflatoxin B1 (AFB1)-induced hepatocarcinogenesis in the rat. Two detoxification enzymes that mediate ethoxyquin-induced chemoprotection against AFB1 have been identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::106b038051440e84edd321d6d28f6321
https://pubmed.ncbi.nlm.nih.gov/8923030

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Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1

Autor: J D, Hayes, T, Nguyen, D J, Judah, D G, Petersson, G E, Neal

Publikováno v: The Journal of biological chemistry. 269(32)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d53884da65a5d354b6944ed4015d1d8a
https://pubmed.ncbi.nlm.nih.gov/8051171

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Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin

Autor: J D, Hayes, D J, Judah, G E, Neal

Publikováno v: Cancer research. 53(17)

Fischer 344 rats readily develop liver cancer when exposed to aflatoxin B1 (AFB1) but dietary administration of the antioxidant ethoxyquin (EQ) provides protection against hepatocarcinogenesis. Chemoprotection by EQ is accompanied by the overexpressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69ebbbd897dd2a3da4487bfc2f6afdf3
https://pubmed.ncbi.nlm.nih.gov/8395332

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A comparison of the effects of aflatoxin B1 on the livers of rats and duck hepatitis B virus-infected and noninfected ducks

Autor: A A, Seawright, R T, Snowden, I O, Olubuyide, J, Riley, D J, Judah, G E, Neal

Publikováno v: Hepatology (Baltimore, Md.). 18(1)

A need exists for an appropriate animal model for the involvement of both hepatitis B virus infection and ingestion of aflatoxins in the etiology of liver cancer. Duck hepatitis B virus-infected ducks, on the basis of hepatoma development in the wild

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3da152128ebfa161c366bafa77eb200b
https://pubmed.ncbi.nlm.nih.gov/8325610

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