Zobrazeno 1 - 8
of 8
pro vyhledávání: '"D J, Fowell"'
Publikováno v:
The Journal of Immunology. 156:2406-2412
Purified rat CD4+ T cells were activated in vitro in the presence or absence of the glucocorticoid dexamethasone. They were then expanded in IL-2 and subsequently restimulated, this time in the absence of the hormone. The results indicate that the ex
Autor:
S D, Pippig, C, Peña-Rossi, J, Long, W R, Godfrey, D J, Fowell, S L, Reiner, M L, Birkeland, R M, Locksley, A N, Barclay, N, Killeen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(12)
CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong responses to a range of challenges, but they showed impaired proliferation in response to di
Autor:
D J, Fowell, R M, Locksley
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 21(6)
Leishmania major infection of inbred mice leads to a major dichotomous response--death or survival--that depends on the strain of mice. This finding has motivated efforts to locate genetic determinants of disease susceptibility. Genotyping studies ha
Publikováno v:
Advances in experimental medicine and biology. 452
The mechanisms by which naive helper T cells differentiate into potent cytokine-expressing effectors remain critical to understanding both successful and aberrant immune responses. Studies using Leishmania major infection of mice have revealed geneti
Publikováno v:
European cytokine network. 9
The murine Leishmania major model has proven fertile ground for the elucidation of CD4+ T cell effector subset differentiation in vivo. The availability of a highly susceptible inbred strain, BALB/c, that develops progressive disease due to the aberr
Autor:
S L, Reiner, D J, Fowell, N H, Moskowitz, K, Swier, D R, Brown, C R, Brown, C W, Turck, P A, Scott, N, Killeen, R M, Locksley
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(2)
Little is known regarding the diversity of the host T cell response that is required to maintain immunologic control of microbial pathogens. Leishmania major persist as obligate intracellular parasites within macrophages of the mammalian host. Immuni
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(7)
Purified rat CD4+ T cells were activated in vitro in the presence or absence of the glucocorticoid dexamethasone. They were then expanded in IL-2 and subsequently restimulated, this time in the absence of the hormone. The results indicate that the ex
Publikováno v:
Ciba Foundation symposium. 195
Leishmania major infection has proven an exceptional model for CD4+ subset development in inbred mice. Most strains contain infection coincident with the appearance of T helper 1 (Th1) cells that produce gamma-interferon (IFN-gamma) required for macr