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Mechanistic differences between migration inhibitory factor (MIF) and IFN-gamma for macrophage activation. MIF and IFN-gamma synergize with lipid A to mediate migration inhibition but only IFN-gamma induces production of TNF-alpha and nitric oxide

Autor: M J Herriott, H Jiang, C A Stewart, D J Fast, R W Leu

Publikováno v: The Journal of Immunology. 150:4524-4531

Previously we found that murine macrophage migration inhibition (MMI) was mediated by IFN-gamma-priming and lipid A triggering. With the recent availability of human recombinant migration inhibitory factor (MIF), which is distinctly different from IF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03091e95e7521c9e4016f332879ac109
https://doi.org/10.4049/jimmunol.150.10.4524

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Tumor target-derived soluble factor synergizes with IFN-gamma and IL-2 to activate macrophages for tumor necrosis factor and nitric oxide production to mediate cytotoxicity of the same target

Autor: H Jiang, C A Stewart, D J Fast, R W Leu

Publikováno v: The Journal of Immunology. 149:2137-2146

Inflammatory mouse peritoneal macrophages were activated by IFN-gamma in synergy with IL-2 or Lipid A to mediate TNF production for autocrine generation of cytotoxic nitric oxide (NO) to kill P815 or L1210 tumor targets. It was determined that for IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a19c547ed243b56b7d66367f5e2cc04
https://doi.org/10.4049/jimmunol.149.6.2137

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Reconstitution of a deficiency of AKR mouse macrophages for their response to lipid A activation for tumor cytotoxicity by complement subcomponent C1q: role of IFN-gamma

Autor: R W Leu, A Q Zhou, J Rummage, D J Fast, B J Shannon

Publikováno v: The Journal of Immunology. 147:1315-1321

C5-deficient AKR mouse macrophages were initially found to be refractory to activation by lipid A to mediate tumor cytotoxicity for P815 mastocytoma or L1210 mouse leukemia targets as compared with responsive C3H mouse macrophages. The lower level of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60dd1dbe0addb9e71c1b8464470e125e
https://doi.org/10.4049/jimmunol.147.4.1315

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Autor: M J, Herriott, H, Jiang, C A, Stewart, D J, Fast, R W, Leu

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 150(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3171a6989982accc27643caa03d3b268
https://pubmed.ncbi.nlm.nih.gov/7683323

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Tumor target-derived soluble factor synergizes with IFN-gamma and IL-2 to activate macrophages for tumor necrosis factor and nitric oxide production to mediate cytotoxicity of the same target

Autor: H, Jiang, C A, Stewart, D J, Fast, R W, Leu

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 149(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3915760a7df63a05f5fe599065b2778f
https://pubmed.ncbi.nlm.nih.gov/1517576

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IFN-gamma differentially modulates the susceptibility of L1210 and P815 tumor targets for macrophage-mediated cytotoxicity. Role of macrophage-target interaction coupled to nitric oxide generation, but independent of tumor necrosis factor production

Autor: R W, Leu, N R, Leu, B J, Shannon, D J, Fast

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 147(6)

IFN-gamma primes murine macrophages to render them responsive for triggering by subactivating concentrations of bacterial LPS to mediate nonspecific tumor cytotoxicity. However, IFN-gamma also has direct anti-proliferative effects on transformed cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::332bb395388dc49e3410af6df5a579d3
https://pubmed.ncbi.nlm.nih.gov/1909732

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Reconstitution of a deficiency of AKR mouse macrophages for their response to lipid A activation for tumor cytotoxicity by complement subcomponent C1q: role of IFN-gamma

Autor: R W, Leu, A Q, Zhou, J, Rummage, D J, Fast, B J, Shannon

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 147(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ec3249f53c6af39c6f2b201a6292757a
https://pubmed.ncbi.nlm.nih.gov/1907994

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Nonpurulent response to toxic shock syndrome toxin 1-producing Staphylococcus aureus. Relationship to toxin-stimulated production of tumor necrosis factor

Autor: D J, Fast, P M, Schlievert, R D, Nelson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 140(3)

Infection of surgical wounds with toxic shock syndrome toxin 1 (TSST-1)-producing Staphylococcus aureus does not usually elicit a purulent response from the host. Because S. aureus is normally a pyogenic pathogen, this phenomenon suggests that strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::574f2599fd6058bb05c31b965fd38934
https://pubmed.ncbi.nlm.nih.gov/3339245

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